{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:24:46Z","timestamp":1787765086681,"version":"build-2784847793"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n Mucormycosis is a fungal infection that can affect multiple organs. The role of fine-needle aspiration cytology (FNAC) in its diagnosis is not well documented.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n The objective of this study was to describe the detailed cytomorphologic features of mucormycosis on FNAC samples.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n A retrospective analysis of all cases diagnosed as mucormycosis on FNAC between January 2014 and July 2021 was performed for detailed cytomorphological evaluation and correlation to clinical data and microbiological studies wherever available. FNA was computed tomography-guided (\n n<\/jats:italic>\n = 38), ultrasonography-guided (\n n<\/jats:italic>\n = 31) or palpation-guided (\n n<\/jats:italic>\n = 12), and slides were reviewed in two cases.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n A total of 83 cases of mucormycosis were evaluated. An immunocompromised setting was observed in 48 cases. The most common site of FNA was the lung (\n n<\/jats:italic>\n = 57) followed by liver, soft tissue, palate, mediastinum, orbital\/ocular region, and lymph node. Isolated renal involvement, a unique feature, was seen in seven cases. The aspirates were necrotic to pus-like or blood-mixed particulate. Broad, nonseptate, foldable, ribbon-like fungal hyphae showing right-angled branching were seen. The tissue reaction was predominantly necro-inflammatory (\n n<\/jats:italic>\n = 36), bland necrotic (\n n<\/jats:italic>\n = 22), mixed inflammatory (\n n<\/jats:italic>\n = 16), suppurative (\n n<\/jats:italic>\n = 5), necrotizing granulomatous (\n n<\/jats:italic>\n = 3), and granulomatous (\n n<\/jats:italic>\n = 1). Immunocompromised patients showed mixed inflammatory responses more frequently. Fungal culture was positive for\n Rhizopus<\/jats:italic>\n species in 2\/13 cases and molecular testing in two additional cases corresponding to\n Rhizopus<\/jats:italic>\n and\n Syncephalastrum<\/jats:italic>\n spp.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n FNA provides quick and conclusive diagnosis of mucormycosis from varied anatomic sites enabling prompt institution of therapy. The tissue response is variable and to some extent dependent on the immune status of the patient.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/joc.joc_107_23","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T02:00:24Z","timestamp":1703728824000},"page":"47-52","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Mucormycosis: Cytomorphological Spectrum in Fine-Needle Aspiration Cytology"],"prefix":"10.4103","volume":"41","author":[{"given":"Malvika","family":"Shastri","sequence":"first","affiliation":[{"name":"Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhika","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reetu","family":"Kundu","sequence":"additional","affiliation":[{"name":"Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranab","family":"Dey","sequence":"additional","affiliation":[{"name":"Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nalini","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parikshaa","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Rohilla","sequence":"additional","affiliation":[{"name":"Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandeep","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen","family":"Kalra","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsimran","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivaprakash M.","family":"Rudramurthy","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,12,28]]},"reference":[{"key":"R1-20240905","first-page":"300","article-title":"Fine-needle aspiration:Another diagnostic modality for rhinocerebralmucormycosis","volume":"21","author":"Nair","year":"1999","journal-title":"DiagnCytopathol"},{"key":"R2-20240905","doi-asserted-by":"crossref","first-page":"179","DOI":"10.4103\/0970-2113.201320","article-title":"Pulmonary mucormycosis diagnosed by convex probe endobronchial ultrasound-guided fine needle aspiration of cavity wall","volume":"34","author":"Nair","year":"2017","journal-title":"Lung India"},{"key":"R3-20240905","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1365-2303.2012.01002.x","article-title":"Fine needle aspiration cytology of primary mucormycosis of the breast in a young immunocompetent pregnant woman","volume":"24","author":"Kumar","year":"2013","journal-title":"Cytopathology"},{"key":"R4-20240905","first-page":"32","article-title":"Pulmonary mucormycosis diagnosed by brushing cytology. 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