{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:34:30Z","timestamp":1787776470983,"version":"build-2784847793"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["J Cytol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Intraoperative tumor evaluation is essential for optimizing surgical decision-making and can prevent the need for unnecessary radical surgeries. Although frozen section (FS) is the gold standard for such evaluations in advanced centers, scrape cytology presents a simpler, cost-effective alternative that could be beneficial in resource-limited settings. However, this technique is often overlooked in favor of FS due to greater pathologist confidence in FS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This study included 80 consecutive intraoperative samples from the Department of Pathology. Both scrape cytology and FS were independently evaluated, and results were compared with those of the final histopathology, taken as the gold standard. Statistical analysis assessed the concordance, sensitivity, specificity, and diagnostic accuracy for each method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Scrape cytology and FS demonstrated a concordance rate of 87.5%, with sensitivity and specificity of 89.3% and 90.4%, respectively, for scrape cytology. Positive predictive value was 83.3%, and negative predictive value was 94%. Scrape cytology significantly reduced diagnostic time, averaging 10\u2009min compared to 20\u2009min for FS. Tissue-specific discrepancies were noted, particularly in lymph nodes and parathyroid cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Scrape cytology proved to be a reliable, cost-effective, and time-efficient alternative to FS, especially in settings where FS is unavailable. Although FS remains optimal for architectural detail, scrape cytology provides high diagnostic accuracy and utility for intraoperative decision-making in resource-limited environments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/joc.joc_159_24","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T14:00:14Z","timestamp":1748527214000},"page":"75-81","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Intraoperative Decision-Making: A Comparative Analysis of Scrape Cytology vs. Frozen Section in Eighty Consecutive Samples"],"prefix":"10.4103","volume":"42","author":[{"given":"Manupriya","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Pathology, All India Institute of Medical Sciences, Bilaspur, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deychen","family":"Meyes","sequence":"additional","affiliation":[{"name":"Department of Pathology, All India Institute of Medical Sciences, Bilaspur, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushma","family":"Bharti","sequence":"additional","affiliation":[{"name":"Department of Pathology, All India Institute of Medical Sciences, Bilaspur, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanderdeep","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Bilaspur, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitresh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, All India Institute of Sciences, Bilaspur, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of ENT, All India Institute of Medical Sciences, Bilaspur, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"CIT0001-20250531","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1159\/000332864","article-title":"Value of cytology as an adjunctive intra-operative diagnostic method. An audit of 2,250 consecutive cases","volume":"41","author":"Scucchi","year":"1997","journal-title":"Acta Cytol"},{"key":"CIT0002-20250531","first-page":"477","article-title":"Role of scrape cytology in rapid intra-operative diagnosis. Value and limitations","volume":"28","author":"Shidham","year":"1984","journal-title":"Acta Cytol"},{"key":"CIT0003-20250531","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ygyno.2004.09.042","article-title":"Diagnostic accuracy of frozen section diagnosis of the adnexal mass: A metaanalysis","volume":"96","author":"Geomini","year":"2005","journal-title":"Gynecol Oncol"},{"key":"CIT0004-20250531","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1136\/ijgc-00009577-200503000-00002","article-title":"Accuracy of frozen-section analysis in the diagnosis of ovarian tumors: A systematic quantitative review","volume":"15","author":"Medeiros","year":"2005","journal-title":"Int J Gynecol Cancer"},{"key":"CIT0005-20250531","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1006\/gyno.1995.0004","article-title":"The accuracy of frozen section diagnosis of borderline ovarian malignancy","volume":"59","author":"Menzin","year":"1995","journal-title":"Gynecol Oncol"},{"key":"CIT0006-20250531","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/1097-0339(200008)23:2<134::AID-DC14>3.0.CO;2-N","article-title":"Intraoperative scrape cytology: Comparison with frozen sections, using receiver operating characteristic curve","volume":"23","author":"Shidham","year":"2000","journal-title":"Diagn Cytopathol"},{"key":"CIT0007-20250531","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/dc.23995","article-title":"Synergy of cytological methods in the pathological staging of breast cancer: Axillary fine-needle aspiration and intraoperative scrape cytology of the sentinel lymph node","volume":"46","author":"Bruzzone","year":"2018","journal-title":"Diagn Cytopathol"},{"key":"CIT0008-20250531","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/cncy.20073","article-title":"Value of cytology in the intraoperative assessment of ovarian tumors: a review of 402 cases and comparison with frozen section diagnosis","volume":"118","author":"Stewart","year":"2010","journal-title":"Cancer Cytopathol"},{"key":"CIT0009-20250531","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/dc.24695","article-title":"Comparing scraping cytology with touch imprint cytology and frozen section analysis in the intraoperative diagnosis of sentinel lymph node metastasis in breast cancer","volume":"49","author":"Mohammadnia Avval","year":"2021","journal-title":"Diagn Cytopathol"},{"key":"CIT0010-20250531","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/dc.10273","article-title":"Scrape cytology of the ovaries: Potential role in intraoperative consultation of ovarian lesions","volume":"28","author":"Khunamornpong","year":"2003","journal-title":"Diagn Cytopathol"},{"key":"CIT0011-20250531","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4103\/JOC.JOC_211_20","article-title":"Diagnostic utility and accuracy of scrape cytology in evaluation of neoplastic lesions","volume":"38","author":"Sharma","year":"2021","journal-title":"J Cytol"},{"key":"CIT0012-20250531","doi-asserted-by":"crossref","first-page":"86","DOI":"10.4103\/0970-9371.71871","article-title":"Role of scrape cytology in the intraoperative diagnosis of tumor","volume":"27","author":"Kolte","year":"2010","journal-title":"J Cytol"},{"key":"CIT0013-20250531","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4103\/JOC.JOC_9_17","article-title":"Intraoperative scrape cytology from ovarian masss lesions: A study of 81 cases","volume":"36","author":"Gupta","year":"2019","journal-title":"J Cytol"},{"key":"CIT0014-20250531","doi-asserted-by":"crossref","first-page":"6633646","DOI":"10.1155\/2021\/6633646","article-title":"Role of intraoperative pathology consultation by imprint and scrape cytology in soft tissue tumors and tumor-like lesions","volume":"2021","author":"Gautam","year":"2021","journal-title":"Sarcoma"},{"key":"CIT0015-20250531","doi-asserted-by":"crossref","first-page":"e600","DOI":"10.1016\/j.clbc.2024.06.002","article-title":"Intraoperative diagnosis of breast cancer metastasis in axillary lymph nodes: Cytological Smear vs. Frozen Section","volume":"24","author":"Malkiely","year":"2024","journal-title":"Clin Breast Cancer"},{"key":"CIT0016-20250531","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/dc.25193","article-title":"Role of scrape cytology smear preparation in the diagnosis of ovarian masses-utility and pitfalls","volume":"51","author":"Agarwal","year":"2023","journal-title":"Diagn Cytopathol"},{"key":"CIT0017-20250531","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s13193-022-01597-5","article-title":"Utility of scrape cytology in management of ovarian neoplasms: A cross-sectional study in a tertiary care hospital of Eastern India","volume":"13","author":"Samaddar","year":"2022","journal-title":"Indian J Surg Oncol"},{"key":"CIT0018-20250531","first-page":"EC13","article-title":"Role of scrape cytology as an adjunct to fine needle aspiration cytology in diagnosis of thyroid lesions","volume":"10","author":"Khuroo","year":"2016","journal-title":"J Clin Diagn Res"},{"key":"CIT0019-20250531","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S1015-9584(09)60267-0","article-title":"Prospective study comparing scrape cytology with frozen section in the intraoperative identification of parathyroid tissue","volume":"28","author":"Rohaizak","year":"2005","journal-title":"Asian J Surg"}],"container-title":["Journal of Cytology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/joc.joc_159_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:10:57Z","timestamp":1787775057000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/joc.joc_159_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/joc.joc_159_24","relation":{},"ISSN":["0970-9371","0974-5165"],"issn-type":[{"value":"0970-9371","type":"print"},{"value":"0974-5165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2024-12-20","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-26","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}