{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:19:14Z","timestamp":1787840354551,"version":"build-2784847793"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["J Cytol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Fine needle aspiration (FNA) cytology for salivary gland lesions is sensitive and specific for diagnosing and treating salivary gland pathologies. The objective of the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) is to organize the diagnostic information from the FNA into a uniform reporting terminology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>The study was conducted retrospectively to reclassify previous diagnoses into the MSRSGC categories to determine the cytohistological concordance and assess the risk stratification by calculating the risk of malignancy (ROM) for different categories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A total of 248 FNA cases of salivary gland lesions were analyzed and reclassified according to the second edition of the MSRSGC. The histological diagnosis was considered the gold standard. The ROM for each category was calculated based on 101 histopathologic follow-up cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the 248 patients, 1.2% were classified as nondiagnostic, 37.9% as nonneoplastic, 1.2% as atypia of undetermined significance (AUS), 52.8% as benign neoplasm, 0.4% as uncertain malignant potential (SUMP), 0.4% as suspicious of malignancy (SFM), and 6.1% as malignant neoplasm. Histopathological correlation was available in 101 cases. The ROM was 0% for nonneoplastic lesions and benign neoplasms, and 100% for AUS, SUMP, SFM, and malignant categories. The sensitivity, specificity, positive predictive value, and negative predictive value of FNA cytology in diagnosing salivary gland lesions using MSRSGC were found to be 76.5%, 100%, 100%, and 95.3%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The use of the MSRSGC helps in triaging patients with salivary gland lesions, increases the effectiveness of communication between clinicians and pathologists, and thus facilitates individualized patient management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/joc.joc_24_24","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T13:00:09Z","timestamp":1739192409000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["The Second Edition of the Milan System for Reporting Salivary Gland Cytopathology: System Application, Outcome, and Cytohistological Correlation"],"prefix":"10.4103","volume":"42","author":[{"given":"Magdalena","family":"Onyszczuk","sequence":"first","affiliation":[{"name":"Department and Chair of Pathomorphology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogna","family":"Drozdzowska","sequence":"additional","affiliation":[{"name":"Department and Chair of Pathomorphology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"key":"CIT0001-20250218","first-page":"5","article-title":"Fine needle aspiration cytology in diagnosis of salivary gland lesions: A study with histologic comparison","volume":"10","author":"Jain","year":"2013","journal-title":"Cytojournal"},{"key":"CIT0002-20250218","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1002\/cncy.21898","article-title":"The Milan System for Reporting Salivary Gland Cytopathology: Analysis and suggestions of initial survey","volume":"125","author":"Rossi","year":"2017","journal-title":"Cancer Cytopathol"},{"key":"CIT0003-20250218","doi-asserted-by":"crossref","first-page":"26","DOI":"10.5858\/2005-129-26-PISGFC","article-title":"Pitfalls in salivary gland fine-needle aspiration cytology: Lessons from the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology","volume":"129","author":"Hughes","year":"2005","journal-title":"Arch Pathol Lab Med"},{"key":"CIT0004-20250218","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1309\/AJCPMII6OSD2HSJA","article-title":"Salivary gland tumor fine-needle aspiration cytology: A proposal for a risk stratification classification","volume":"143","author":"Griffith","year":"2015","journal-title":"Am J Clin Pathol"},{"key":"CIT0005-20250218","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.5858\/arpa.2013-0173-CP","article-title":"Performance characteristics of adenoid cystic carcinoma of the salivary glands in fine-needle aspirates. Results from the College of American Pathologists Nongynecologic Cytology Program","volume":"139","author":"Tabatabai","year":"2015","journal-title":"Arch Pathol Lab Med"},{"key":"CIT0006-20250218","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.5858\/arpa.2015-0222-RA","article-title":"Fine-needle aspiration biopsy of salivary gland lesions","volume":"139","author":"Wang","year":"2015","journal-title":"Arch Pathol Lab Med"},{"key":"CIT0007-20250218","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1002\/cncy.22040","article-title":"The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC): An international effort toward improved patient care-when the roots might be inspired by Leonardo da Vinci","volume":"126","author":"Rossi","year":"2018","journal-title":"Cancer Cytopathol"},{"key":"CIT0008-20250218","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000510720","article-title":"The Milan System for Reporting Salivary Gland Cytopathology: 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