{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:30:37Z","timestamp":1787758237038,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Detection of malignant cells in cerebrospinal fluid (CSF) samples in suspected cases of malignancy is critical for the management of patients. CSF involvement by nonhaematolymphoid malignancies is less common. We aimed to study the cytomorphologic characteristics of various nonhaematolymphoid malignancies in CSF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective cytomorphological analysis of 27 CSF cytology smears reported as positive or suspicious for nonhematolymphoid malignancies from January 2010 to April 2020 over 10 years was carried out. Smears in all cases were prepared by cytospin technique and stained with May-Grunwald-Giemsa (MGG) and papanicolaou (Pap) staining procedures. Cell immunohistochemistry\/immunocytochemistry was done wherever cell block\/extra slides were available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Twenty-four of 27 cases were interpreted as \u201cpositive,\u201d while three were reported as \u201csuspicious\u201d of malignancy. Nineteen of 27 cases were metastatic adenocarcinomas including three suspicious malignancy cases with the primary sites of origin being the breast (10), stomach (2), rectum (1), gall bladder (1), lung (1), and four cases of unknown primary. Of the remaining positive cases, there were five cases of metastatic medulloblastoma, two cases of metastatic pineoblastomas, and one case of metastatic extraskeletal Ewings sarcoma. Each of these metastatic malignancies had at least a single diagnostic cytomorphological clue, similar to those observed in other body cavities and primary malignancy sites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Nonhematolymphoid malignancies are readily diagnosable on CSF cytology, most of them are metastatic. Identification of malignant cells in CSF is critical, as it has therapeutic and prognostic implications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/joc.joc_66_22","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T05:19:04Z","timestamp":1660713544000},"page":"126-130","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["CSF Involvement by Nonhematolymphoid Malignancies"],"prefix":"10.4103","volume":"39","author":[{"given":"Vidhya Vikashini","family":"Balasubramaniam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saranya","family":"Mohan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suganya Kuppovi","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinkala Sree","family":"Rekha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debasis","family":"Gochhait","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelaiah","family":"Siddaraju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-7-20240905","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1634\/theoncologist.2008-0138","article-title":"Neoplastic meningitis","volume":"13","author":"Chamberlain","year":"2008","journal-title":"Oncologist"},{"key":"R3-7-20240905","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4103\/0970-9371.40655","article-title":"Metastatic gastric adenocarcinoma to the cerebrospinal fluid: A report of three cases","volume":"25","author":"Kotwal","year":"2008","journal-title":"J Cytol"},{"key":"R4-7-20240905","doi-asserted-by":"crossref","first-page":"10445","DOI":"10.1038\/s41598-018-28662-w","article-title":"Leptomeningeal metastasis from solid tumors: Clinical features and its diagnostic implication?","volume":"8","author":"Pan","year":"2018","journal-title":"Sci Rep"},{"key":"R5-7-20240905","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s11912-009-0079-2","article-title":"Biology and therapy of neoplastic meningitis","volume":"12","author":"Mammoser","year":"2010","journal-title":"Curr Oncol Rep"},{"key":"R6-7-20240905","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1002\/cncr.21082","article-title":"Neoplastic meningitis in patients with adenocarcinoma of the gastrointestinal tract","volume":"103","author":"Giglio","year":"2005","journal-title":"Cancer"},{"key":"R7-7-20240905","first-page":"1","article-title":"Cerebrospinal fluid cytology in cancer patients: An Institutional study with 5394 cases","volume":"9","author":"Patel","year":"2017","journal-title":"Int J Cur Res Rev"},{"key":"R9-7-20240905","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/cncy.21633","article-title":"Young investigator challenge: Cytomorphologic analysis of cerebrospinal fluid in 70 pediatric patients with medulloblastoma and review of the literature focusing on novel diagnostic and prognostic tests","volume":"123","author":"Domenico","year":"2015","journal-title":"Cancer Cytopathol"},{"key":"R10-7-20240905","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/(SICI)1097-0142(19990625)87:3<141::AID-CNCR7>3.0.CO;2-C","article-title":"The cytology of extraskeletal Ewing sarcoma","volume":"87","author":"Guiter","year":"1999","journal-title":"Cancer"},{"key":"R11-7-20240905","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/tbj.12766","article-title":"Metastatic breast carcinoma in cerebrospinal fluid: A cytopathological review of 15 cases","volume":"23","author":"Rao","year":"2017","journal-title":"Breast J"}],"container-title":["Journal of Cytology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/joc.joc_66_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:10:11Z","timestamp":1787757011000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/joc.joc_66_22"}},"subtitle":["A Descriptive Study with Emphasis on Cytomorphological Clues"],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/joc.joc_66_22","relation":{},"ISSN":["0970-9371"],"issn-type":[{"value":"0970-9371","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]}}}