{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:23:11Z","timestamp":1787757791150,"version":"build-2784847793"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To describe a case where prophylactic use of nonsteroidal anti-inflammatory drugs (NSAID) eye drops lead to recurrent corneal melt with loss of vision and a brief literature review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This is a case report of an 84-year-old diabetic female with chronic dry eye, operated by two different surgeons on each eye at different time intervals. She received topical NSAID prophylaxis after the second surgery only, which led to blindness due to recurrent corneal melt and chronic choroidal effusions. We also present a brief literature review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>This lady presented with corneal melt and perforation 5 days following the use of topical NSAIDs prophylaxis after a routine cataract surgery in the second eye. Unfortunately, all efforts to save her vision and eye were unsuccessful as she developed repeated complications in spite of corneal gluing, amniotic membrane, penetrating keratoplasty, and tarsorrhaphy. She also had chronic choroidal effusions. She ended up with an opaque cornea and a subtotal tarsorrhaphy, with no other option to improve her vision as she did not qualify for sedation or general anesthesia due to her poor systemic health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although it is a common practice for diabetic patients to have topical NSAIDs prophylaxis in combination with steroid eye drops to reduce the risk of cystoid macular edema after cataract surgery, the elderly diabetic patients with concomitant dry eyes should be considered high risk for corneal melt and should be closely monitored. This case highlights the rare but serious complication of topical NSAIDs prophylaxis in the vulnerable cornea, which warrants careful consideration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/joco.joco_107_21","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T01:10:45Z","timestamp":1641431445000},"page":"485-491","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Prophylactic Use of Nonsteroidal Anti-Inflammatory Drugs after Cataract Surgery and Corneal Melt"],"prefix":"10.4103","volume":"33","author":[{"given":"Zahra","family":"Ashena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayank A.","family":"Nanavaty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed S.","family":"Bardan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riddhi","family":"Thaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Bascaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-19-20240910","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.jcrs.2019.04.025","article-title":"Prevention of macular edema in patients with diabetes after cataract surgery","volume":"45","author":"Laursen","year":"2019","journal-title":"J Cataract Refract Surg"},{"key":"R2-19-20240910","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jcrs.2018.01.029","article-title":"European multicenter trial of the prevention of cystoid macular edema after cataract surgery in nondiabetics: ESCRS PREMED study report 1","volume":"44","author":"Wielders","year":"2018","journal-title":"J Cataract Refract Surg"},{"key":"R3-19-20240910","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/j.ophtha.2014.04.035","article-title":"Post-cataract prevention of inflammation and macular edema by steroid and nonsteroidal anti-inflammatory eye drops: A systematic review","volume":"121","author":"Kessel","year":"2014","journal-title":"Ophthalmology"},{"key":"R4-19-20240910","first-page":"138","article-title":"Severe corneal melting following cataract surgery in patients prescribed topical post-operative NSAIDs and a dexamethasone\/neomycin combination therapy","volume":"46","author":"Cabourne","year":"2020","journal-title":"J Cataract Refract Surg"},{"key":"R5-19-20240910","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/S0886-3350(01)00866-5","article-title":"Effects of antiinflammatory drugs on migration of the rabbit corneal epithelium","volume":"27","author":"Hashizume","year":"2001","journal-title":"J Cataract Refract Surg"},{"key":"R6-19-20240910","first-page":"1129","article-title":"Corneal melting associated with use of topical nonsteroidal anti-inflammatory drugs after ocular surgery","volume":"118","author":"Lin","year":"2000","journal-title":"Arch Ophthalmol"},{"key":"R8-19-20240910","first-page":"2515841419869508","article-title":"Acute corneal perforation 1 week following uncomplicated cataract surgery: The implication of undiagnosed dry eye disease and topical NSAIDs","volume":"11","author":"Ting","year":"2019","journal-title":"Ther Adv Ophthalmol"},{"key":"R9-19-20240910","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1159\/000444437","article-title":"Corneal melting after collagen cross-linking for keratoconus in a thin cornea of a diabetic patient treated with topical nepafenac: A case report with a literature review","volume":"7","author":"Mohamed-Noriega","year":"2016","journal-title":"Case Rep Ophthalmol"},{"key":"R10-19-20240910","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.xjec.2019.12.002","article-title":"Corneal perforation associated with the use of ketorolac tromethamine after cataract surgery","volume":"6","author":"Jesus","year":"2020","journal-title":"J EuCornea"},{"key":"R11-19-20240910","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1016\/j.jcrs.2007.06.043","article-title":"Nepafenac-associated corneal melt","volume":"33","author":"Wolf","year":"2007","journal-title":"J Cataract Refract Surg"},{"key":"R12-19-20240910","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ajoc.2018.12.004","article-title":"Three cases of acute sterile corneal melt after cataract surgery","volume":"13","author":"Harada","year":"2019","journal-title":"Am J Ophthalmol Case Rep"},{"key":"R13-19-20240910","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/ICL.0b013e318235c506","article-title":"Acute corneal melt associated with topical bromfenac use","volume":"38","author":"Prasher","year":"2012","journal-title":"Eye Contact Lens"},{"key":"R14-19-20240910","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/ICO.0b013e3181ef6ec7","article-title":"Keratitis and corneal melt with ketorolac tromethamine after conductive keratoplasty","volume":"30","author":"Khalifa","year":"2011","journal-title":"Cornea"},{"key":"R15-19-20240910","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/01.ico.0000179931.05275.dd","article-title":"Corneal ulceration and perforation with ketorolac tromethamine (Acular) use after PRK","volume":"25","author":"Mian","year":"2006","journal-title":"Cornea"},{"key":"R16-19-20240910","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1097\/ICO.0b013e318199e9cc","article-title":"Nepafenac-associated bilateral corneal melt after photorefractive keratectomy","volume":"28","author":"Feiz","year":"2009","journal-title":"Cornea"},{"key":"R17-19-20240910","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1097\/01.ico.0000177835.93130.d4","article-title":"Three cases of corneal melting after instillation of a new nonsteroidal anti-inflammatory drug","volume":"25","author":"Asai","year":"2006","journal-title":"Cornea"},{"key":"R18-19-20240910","first-page":"205","article-title":"Corneal melts associated with topically applied nonsteroidal anti-inflammatory drugs","volume":"99","author":"Flach","year":"2001","journal-title":"Trans Am Ophthalmol Soc"},{"key":"R19-19-20240910","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/S0161-6420(00)00538-8","article-title":"Keratitis ulceration, and perforation associated with topical nonsteroidal anti-inflammatory drugs","volume":"108","author":"Guidera","year":"2001","journal-title":"Ophthalmology"},{"key":"R20-19-20240910","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1136\/bjo.2008.155432","article-title":"Severe corneal complications associated with topical indomethacin use","volume":"94","author":"Gueudry","year":"2010","journal-title":"Br J Ophthalmol"},{"key":"R21-19-20240910","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/S0886-3350(98)80107-7","article-title":"Cataract surgery in patients with dry eyes","volume":"24","author":"Ram","year":"1998","journal-title":"J Cataract Refract Surg"}],"container-title":["Journal of Current Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/joco.joco_107_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:53:36Z","timestamp":1787756016000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/joco.joco_107_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/joco.joco_107_21","relation":{},"ISSN":["2452-2325"],"issn-type":[{"value":"2452-2325","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]}}}