{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:53:54Z","timestamp":1788368034513,"version":"build-2803163510"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To investigate the retinal vascular characteristics among patients with different types of inherited retinal dystrophies (IRDs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This comparative cross-sectional study was conducted on 59 genetically confirmed cases of IRD including 37 patients with retinitis pigmentosa (RP) (74 eyes), 13 patients with Stargardt disease (STGD) (26 eyes), and 9 patients with cone-rod dystrophy (CRD) (18 eyes). Both eyes of 50 age- and sex-matched healthy individuals were investigated as controls. All participants underwent optical coherence tomography angiography to investigate the vascular densities (VDs) of superficial and deep capillary plexus (SCP and DCP) as well as foveal avascular zone area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In RP, significantly lower VD in whole image (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001 for DCP), fovea (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.038 for SCP), parafovea (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001 for SCP and DCP), and perifovea (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001 for SCP and DCP) was observed compared to controls. In STGD, VD of parafovea (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.012 for SCP and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001 for DCP) and fovea (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.016 for DCP) was significantly lower than controls. In CRD, the VD of parafovea (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.025 for DCP) was significantly lower than controls. Whole image density was significantly lower in RP compared to STGD (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001 for SCP) and CRD (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.037 for SCP). VD in parafovea (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.005 for SCP) and perifovea (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001 for SCP and DCP) regions was significantly lower in RP compared with STGD. Also, foveal VD in STGD was significantly lower than RP (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.023 for DCP).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our study demonstrated lower VDs in three different IRDs including RP, STGD, and CRD compared to healthy controls. Changes were more dominant in RP patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/joco.joco_11_21","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T06:19:19Z","timestamp":1626329959000},"page":"189-196","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":12,"title":["Retinal Vascular Abnormalities in Different Types of Inherited Retinal Dystrophies Assessed by Optical Coherence Tomography 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