{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:30:24Z","timestamp":1786649424969,"version":"build-2736575974"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To report a rare case of central toxic keratopathy (CTK) after photorefractive keratectomy (PRK).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A 22-year-old male underwent bilateral PRK for the correction of myopic astigmatism. Preoperative refraction measurements were \u22122.50 \u22121.00 \u00d7 65 in the right eye and \u22123.50 diopter (D) sphere in the left eye. The intended refractive correction was \u22123.25 \u22121.00 \u00d7 65 (in the right eye) and \u22124.25 D sphere in the left eye. Preoperative corneal thickness measured 489 \u03bcm (in the right eye) and 491 \u03bcm in the left eye, both values exceeding the minimum safe threshold for PRK.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>At the 1-week postoperative evaluation, slit-lamp examination and optical coherence tomography (OCT) revealed significant central corneal haziness, thinning, and flattening, along with hyperopic astigmatism. These findings were consistent with CTK. The surgeon adopted a conservative approach, closely monitoring the patient without initiating pharmacological intervention. By the 6-month follow-up, the patient demonstrated reduced hyperopia and achieved a best-corrected visual acuity of 20\/20. OCT imaging also confirmed increased central corneal and epithelial thickness, suggesting progressive recovery. Long-term follow-up over 2 years showed stable refraction and corneal thickness, with no further significant changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      CTK is a rare but vision-threatening complication of refractive surgery, occurring not only after laser\n                      <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                      keratomileusis but also following other refractive surgery approaches. Enhancing clinical knowledge of both its presentation and differential diagnosis is essential to avoid any unnecessary interventions.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/joco.joco_125_25","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T14:00:47Z","timestamp":1766152847000},"page":"259-262","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Central Toxic Keratopathy after Photorefractive Keratectomy: Two-Year Follow-Up Case Report and Review of the Literature"],"prefix":"10.4103","volume":"37","author":[{"given":"Javad","family":"Sadeghi","sequence":"first","affiliation":[{"name":"Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negareh","family":"Yazdani","sequence":"additional","affiliation":[{"name":"Department of Optometry, School of 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