{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:19:53Z","timestamp":1787840393683,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To report a case of presumed solitary circumscribed retinal astrocytic proliferation (PSCRAP) diagnosed through multimodal imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A single case report documented with multimodal imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A 41-year-old asymptomatic female was referred for a second opinion regarding whitish retinal lesions in her left eye, first identified by her local optometrist 8 years prior. Her history included Hashimoto thyroiditis, with no personal or family history of tuberous sclerosis complex or neurofibromatosis. Visual acuity was 20\/20 in both eyes. Fundoscopy of the left eye revealed two pearly white avascular retinal masses. Spectral-domain optical coherence tomography (SD-OCT) showed hyperreflective intraretinal masses with optical shadowing. Optical coherence tomography angiography (OCTA) demonstrated a signal void in the retinal vascular plexuses. Fundus autofluorescence showed moderate hyperautofluorescence. The lesions remained stable over 3 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>PSCRAP is a rare, benign retinal tumor. Multimodal imaging, including SD-OCT and OCTA, is essential for accurate diagnosis, showing unique features such as separation from the retinal nerve fiber layer and lack of intrinsic vascularity. Our observation of two lesions raises questions about the solitary nature of this condition. Continued documentation may be necessary to differentiate from simulating lesions that may undergo subsequent growth.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/joco.joco_136_24","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T16:03:42Z","timestamp":1749139422000},"page":"296-299","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Presumed Solitary Circumscribed Retinal Astrocytic Proliferation: A Case Report"],"prefix":"10.4103","volume":"36","author":[{"given":"Mojtaba","family":"Abrishami","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Vision Sciences, Princess Margaret Cancer Center\/University Health Network, University of Toronto, Toronto, ON, Canada"},{"name":"Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Weisbrod","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Sciences, Princess Margaret Cancer Center\/University Health Network, University of Toronto, Toronto, ON, Canada"},{"name":"Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatem","family":"Krema","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Sciences, Princess Margaret Cancer Center\/University Health Network, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"R1-20250605","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1001\/archophthalmol.2011.211","article-title":"Presumed solitary circumscribed retinal astrocytic proliferation: The 2010 Jonathan W. Wirtschafter lecture","volume":"129","author":"Shields","year":"2011","journal-title":"Arch Ophthalmol"},{"key":"R2-20250605","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/ICB.0000000000000278","article-title":"Solitary circumscribed \u201cpearl white\u201d retinal mass (so-called retinal astrocytic proliferation) resides in deep retina or beneath retina: Findings on multimodal imaging in 4 cases","volume":"11","author":"Shields","year":"2017","journal-title":"Retin Cases Brief Rep"},{"key":"R3-20250605","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3928\/23258160-20180221-11","article-title":"Presumed solitary circumscribed retinal astrocytic proliferation in the fovea with OCT angiography: A misnomer","volume":"49","author":"Goldberg","year":"2018","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"key":"R4-20250605","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.1016\/j.jcjo.2020.10.001","article-title":"A case of multifocal presumed solitary circumscribed retinal astrocytic proliferation lesions in the same eye","volume":"56","author":"McKay","year":"2021","journal-title":"Can J Ophthalmol"},{"key":"R5-20250605","doi-asserted-by":"crossref","first-page":"421","DOI":"10.4274\/tjo.galenos.2022.25979","article-title":"Hamartomas of the retina and optic disc","volume":"52","author":"Mirzayev","year":"2022","journal-title":"Turk J Ophthalmol"},{"key":"R6-20250605","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/s41433-022-01980-0","article-title":"Retinoblastoma: Emerging concepts in genetics, global disease burden, chemotherapy outcomes, and psychological impact","volume":"37","author":"Shields","year":"2023","journal-title":"Eye (Lond)"},{"key":"R7-20250605","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1590\/S0004-27492013000300016","article-title":"Retinal vasoproliferative tumor","volume":"76","author":"Marback","year":"2013","journal-title":"Arq Bras Oftalmol"},{"key":"R8-20250605","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1038\/s41433-022-02275-0","article-title":"Diagnostic imaging of retinal astrocytomas: A case-series","volume":"37","author":"McLean","year":"2023","journal-title":"Eye (Lond)"}],"container-title":["Journal of Current Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/joco.joco_136_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:21:55Z","timestamp":1787836915000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/joco.joco_136_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/joco.joco_136_24","relation":{},"ISSN":["2452-2325"],"issn-type":[{"value":"2452-2325","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2024-07-06","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-06","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}