{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:21:14Z","timestamp":1787775674991,"version":"build-2784847793"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10]]},"abstract":"Abstract<\/jats:title>\n \n Purpose:<\/jats:title>\n To investigate peripapillary retinal nerve fiber layer (pRNFL) thickness changes in preterm children with or without retinopathy of prematurity (ROP) history compared to full-term children.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n A retrospective comparative cohort study assessing pRNFL thickness was completed in children aged 4\u20138 years. Four groups of children were included (\n n<\/jats:italic>\n = 30 each group): children with a history of ROP who were treated with intravitreal bevacizumab, children with ROP who received no treatment, and preterm children without ROP compared to age- and gender-matched full-term children.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n A total of 120 eyes from 120 children were enrolled in this study. Both treated and regressed ROP children showed a significantly thinner pRNFL in the nasal quadrant compared to full-term children (\n P<\/jats:italic>\n = 0.017 and\n P<\/jats:italic>\n = 0.008, respectively). The pRNFL in the superior quadrant of treated ROP children was thinner than the preterm and control groups (\n P<\/jats:italic>\n = 0.015 and\n P<\/jats:italic>\n = 0.023, respectively), whereas the inferior quadrant of treated ROP children was thinner than the preterm group alone (\n P<\/jats:italic>\n = 0.008). The pRNFL thickness in the temporal quadrant was comparable between groups (\n P<\/jats:italic>\n = 0.129). The average spatial distribution profile of pRNFL thickness in treated ROP children was significantly thinner than in the preterm group (\n P<\/jats:italic>\n = 0.041).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n pRNFL thickness is significantly altered in children with a prior history of treated ROP with thinning of the nasal and superior quadrants compared to full-term children.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/joco.joco_159_23","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T15:57:53Z","timestamp":1725983873000},"page":"381-386","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Peripapillary Retinal Nerve Fiber Layer Thickness Changes in Preterm Children with or without Retinopathy of Prematurity History"],"prefix":"10.4103","volume":"35","author":[{"given":"Siamak","family":"Zarei-Ghanavati","sequence":"first","affiliation":[{"name":"Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Ostadimoghaddam","sequence":"additional","affiliation":[{"name":"Refractive Errors Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzieh","family":"Najjaran","sequence":"additional","affiliation":[{"name":"Department of Optometry, School of Paramedical Sciences and Rehabilitation, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasser","family":"Shoeibi","sequence":"additional","affiliation":[{"name":"Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Ziaei","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,8,10]]},"reference":[{"key":"R1-20240910","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1038\/s41598-023-30166-1","article-title":"Retinal and peripapillary vascular deformations in prematurely born children aged 4-12 years with a history of retinopathy of prematurity","volume":"13","author":"Lee","year":"2023","journal-title":"Sci Rep"},{"key":"R2-20240910","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.ajo.2014.12.015","article-title":"Microstructural changes in the retina related to prematurity","volume":"159","author":"Pueyo","year":"2015","journal-title":"Am J Ophthalmol"},{"key":"R3-20240910","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.joco.2018.10.008","article-title":"Comparison of intravitreal bevacizumab injection and laser 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children","volume":"153","author":"Wang","year":"2012","journal-title":"Am J Ophthalmol"},{"key":"R10-20240910","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s10792-020-01666-0","article-title":"Retinal choroidal and retinal nerve fiber layer thickness in former preterm and full-term infants aged 4 to 8 years","volume":"41","author":"Acar","year":"2021","journal-title":"Int Ophthalmol"},{"key":"R11-20240910","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1007\/s00431-023-04965-7","article-title":"Refractive status and retinal morphology in children with a history of intravitreal ranibizumab for retinopathy of prematurity","volume":"182","author":"Cheng","year":"2023","journal-title":"Eur J Pediatr"},{"key":"R12-20240910","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/eye.2017.156","article-title":"The inner retinal structures of the eyes of children with a history of retinopathy of prematurity","volume":"32","author":"Lee","year":"2018","journal-title":"Eye (Lond)"},{"key":"R13-20240910","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ajo.2022.07.019","article-title":"Peripapillary retinal nerve fiber layer thickness in adults born extremely, very, and moderately preterm with and without retinopathy of prematurity: Results from the gutenberg prematurity eye study (GPES)","volume":"244","author":"Fie\u00df","year":"2022","journal-title":"Am J Ophthalmol"},{"key":"R14-20240910","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.ajo.2015.09.015","article-title":"Thinner retinal nerve fiber layer in very preterm versus term infants and relationship to brain anatomy and neurodevelopment","volume":"160","author":"Rothman","year":"2015","journal-title":"Am J Ophthalmol"},{"key":"R15-20240910","first-page":"121","article-title":"Acute and chronic effects of intravitreal bevacizumab on lung biomarkers of angiogenesis in the rat exposed to 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