{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:27:54Z","timestamp":1787772474523,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To present a series of cases demonstrating pulsatile ocular blood flow registered with optical coherence tomography angiography (OCTA) and to describe the clinical characteristics of this phenomenon.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Seven primary open-angle glaucoma patients (eight eyes) were included, with a median age of 67.0 years (range, 39\u201373 years), who demonstrated alternating hypointense bands of OCTA flow signal on the macular scan at increased intraocular pressure (IOP). All patients received comprehensive ophthalmic examination, OCTA examination with RTVue-XR, and infrared video scanning laser ophthalmoscopy. Changes in retinal microcirculation were assessed on the raw OCTA scans as well as the resultant vessel density maps before and after IOP reduction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Median IOP in study eyes was 39.0 mmHg (range, 36\u201358 mmHg). Hypointense bands of OCTA flow signal were associated with arterial pulsation on video scanning laser ophthalmoscopy in all eyes and agreed with the heart rate and resulted in a spotted grid pattern of hypoperfusion on vessel density maps in seven eyes. Median vessel density in superficial capillary plexus and deep capillary plexus was 32.4% and 47.2%, respectively, at high IOP, and increased statistically significantly to 36.5% (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.016) and 50.9% (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.016), respectively, after IOP reduction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Alternating hypointense flow signal bands on OCTA scans are possibly caused by the pulsatile character of retinal blood flow during the cardiac cycle in eyes with high IOP and may reflect the imbalance between IOP and perfusion pressure. This phenomenon is responsible for the reversible decrease of vessel density at high IOP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/joco.joco_161_22","type":"journal-article","created":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T18:38:30Z","timestamp":1717267110000},"page":"398-403","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Pulsatile Ocular Blood Flow Registered with Optical Coherence Tomography Angiography in Patients with High Intraocular Pressure"],"prefix":"10.4103","volume":"34","author":[{"given":"Dmitrii S.","family":"Maltsev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexei N.","family":"Kulikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Burnasheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-2-20240910","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/j.ophtha.2021.03.036","article-title":"OCT angiography artifacts in glaucoma","volume":"128","author":"Kamalipour","year":"2021","journal-title":"Ophthalmology"},{"key":"R2-2-20240910","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1097\/IAE.0000000000000765","article-title":"Image artifacts in optical coherence tomography angiography","volume":"35","author":"Spaide","year":"2015","journal-title":"Retina"},{"key":"R3-2-20240910","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2017.11.003","article-title":"Optical coherence tomography angiography","volume":"64","author":"Spaide","year":"2018","journal-title":"Prog Retin Eye Res"},{"key":"R4-2-20240910","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1136\/bjophthalmol-2018-312258","article-title":"Morphological and topographical appearance of microaneurysms on optical coherence tomography angiography","volume":"103","author":"Schreur","year":"2019","journal-title":"Br J Ophthalmol"},{"key":"R5-2-20240910","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1167\/iovs.18-23872","article-title":"The impact of intraocular pressure elevation on optic nerve head and choroidal blood flow","volume":"59","author":"Kiyota","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R6-2-20240910","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1159\/000112624","article-title":"A comparative study of bimatoprost and travoprost: Effect on intraocular pressure and ocular circulation in newly diagnosed glaucoma patients","volume":"222","author":"Alagoz","year":"2008","journal-title":"Ophthalmologica"},{"key":"R7-2-20240910","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1076\/ceyr.16.10.1024.9024","article-title":"Effects of changes in intraocular pressure on human ocular haemodynamics","volume":"16","author":"Findl","year":"1997","journal-title":"Curr Eye Res"},{"key":"R8-2-20240910","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1097\/IJG.0000000000000527","article-title":"Influence of large intraocular pressure reduction on peripapillary OCT vessel density in ocular hypertensive and glaucoma eyes","volume":"26","author":"Holl\u00f3","year":"2017","journal-title":"J Glaucoma"},{"key":"R9-2-20240910","doi-asserted-by":"crossref","first-page":"16505","DOI":"10.1038\/s41598-020-73585-0","article-title":"Differential reperfusion patterns in retinal vascular plexuses following increase in intraocular pressure an OCT angiography study","volume":"10","author":"Cheung","year":"2020","journal-title":"Sci Rep"},{"key":"R10-2-20240910","doi-asserted-by":"crossref","first-page":"17251","DOI":"10.1038\/s41598-021-96225-7","article-title":"Optical coherence tomographic angiography study of perfusion recovery after surgical lowering of intraocular pressure","volume":"11","author":"Liu","year":"2021","journal-title":"Sci Rep"},{"key":"R11-2-20240910","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/IJG.0000000000001142","article-title":"Optic nerve head perfusion before and after intravitreal antivascular growth factor injections using optical coherence tomography-based microangiography","volume":"28","author":"Wen","year":"2019","journal-title":"J Glaucoma"},{"key":"R12-2-20240910","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1076\/stra.9.1.13.711","article-title":"Ophthalmodynamometry: A reliable method for measuring intracranial pressure","volume":"9","author":"Motschmann","year":"2001","journal-title":"Strabismus"},{"key":"R13-2-20240910","doi-asserted-by":"crossref","first-page":"100841","DOI":"10.1016\/j.preteyeres.2020.100841","article-title":"Ocular blood flow as a clinical observation: Value, limitations and data analysis","volume":"78","author":"Harris","year":"2020","journal-title":"Prog Retin Eye Res"},{"key":"R14-2-20240910","doi-asserted-by":"crossref","first-page":"308505","DOI":"10.1155\/2015\/308505","article-title":"Ocular blood flow and normal tension glaucoma","volume":"2015","author":"Fan","year":"2015","journal-title":"Biomed Res Int"},{"key":"R15-2-20240910","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1364\/BOE.4.001909","article-title":"Blood flow velocity quantification using split-spectrum amplitude-decorrelation angiography with optical coherence tomography","volume":"4","author":"Tokayer","year":"2013","journal-title":"Biomed Opt Express"}],"container-title":["Journal of Current Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/joco.joco_161_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:48:56Z","timestamp":1787770136000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/joco.joco_161_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/joco.joco_161_22","relation":{},"ISSN":["2452-2325"],"issn-type":[{"value":"2452-2325","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]}}}