{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:21:31Z","timestamp":1787775691825,"version":"build-2784847793"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To report a case of progressive Chiari malformation type I (CIM) in a patient with unilateral sporadic retinoblastoma (RB) treated with intra-arterial chemotherapy (IAC) and enucleation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A 5-year-old male patient with a history of RB in his left eye treated with IAC and enucleation presented to our clinic for routine RB surveillance. Radiotherapy had not been used for the treatment of his RB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A progressive herniation of cerebellar tonsils through the foramen magnum was detected on follow-up magnetic resonance imaging (MRI). Brain and cervical MRI revealed no central nervous system mass, hydrocephalus, or syringomyelia. There was no history of head trauma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Progressive CIM may occur in unilateral sporadic RB.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/joco.joco_166_20","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T15:08:46Z","timestamp":1725980926000},"page":"88-90","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Development of Progressive Chiari I Malformation in a Child with Unilateral Sporadic Retinoblastoma"],"prefix":"10.4103","volume":"33","author":[{"given":"Saeed","family":"Karimi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Arabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toktam","family":"Shahraki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sare","family":"Safi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-15-20240910","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1007\/s00381-007-0428-0","article-title":"The pediatric Chiari I malformation: A review","volume":"23","author":"Tubbs","year":"2007","journal-title":"Childs Nerv Syst"},{"key":"R2-15-20240910","first-page":"795","article-title":"Significance of cerebellar tonsillar position on MR","volume":"7","author":"Barkovich","year":"1986","journal-title":"AJNR Am J Neuroradiol"},{"key":"R3-15-20240910","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3171\/2010.12.PEDS10379","article-title":"Institutional experience with 500 cases of surgically treated pediatric Chiari malformation Type I","volume":"7","author":"Tubbs","year":"2011","journal-title":"J Neurosurg Pediatr"},{"key":"R4-15-20240910","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00381-003-0878-y","article-title":"History, anatomic forms, and pathogenesis of Chiari I malformations","volume":"20","author":"Schijman","year":"2004","journal-title":"Childs Nerv Syst"},{"key":"R7-15-20240910","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/bjc.1992.244","article-title":"Patterns of risk of hereditary retinoblastoma and applications to genetic counselling","volume":"66","author":"Draper","year":"1992","journal-title":"Br J Cancer"},{"key":"R8-15-20240910","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1086\/514845","article-title":"Constitutional RB1-gene mutations in patients with isolated unilateral retinoblastoma","volume":"61","author":"Lohmann","year":"1997","journal-title":"Am J Hum Genet"},{"key":"R9-15-20240910","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1159\/000339169","article-title":"Progressive development of Chiari I malformation in a child with trilateral retinoblastoma and acquired growth hormone deficiency","volume":"47","author":"Maugans","year":"2011","journal-title":"Pediatr Neurosurg"},{"key":"R10-15-20240910","first-page":"133","article-title":"Acquired Chiari malformation type I following fractionated radiation therapy to the anterior skull base in a 20-month-old boy","volume":"104","author":"Lollis","year":"2006","journal-title":"Case report. J Neurosurg"},{"key":"R11-15-20240910","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1007\/s00198-017-4032-1","article-title":"The skeletal impact of the chemotherapeutic agent etoposide","volume":"28","author":"Koh","year":"2017","journal-title":"Osteoporos Int"},{"key":"R12-15-20240910","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1002\/ajmg.a.31546","article-title":"Phenotypic definition of Chiari type I malformation coupled with high-density SNP genome screen shows significant evidence for linkage to regions on chromosomes 9 and 15","volume":"140","author":"Boyles","year":"2006","journal-title":"Am J Med Genet A"},{"key":"R13-15-20240910","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1158\/1541-7786.MCR-08-0176","article-title":"The retinoblastoma protein tumor suppressor is important for appropriate osteoblast differentiation and bone development","volume":"6","author":"Berman","year":"2008","journal-title":"Mol Cancer Res"}],"container-title":["Journal of Current Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/JOCO.JOCO_166_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:39:24Z","timestamp":1787773164000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/JOCO.JOCO_166_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/joco.joco_166_20","relation":{},"ISSN":["2452-2325"],"issn-type":[{"value":"2452-2325","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}