{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:28:13Z","timestamp":1787772493703,"version":"build-2784847793"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the changes in biomechanical properties of the cornea using the Corvis ST device after the treatment of keratoconus patients with ultraviolet-A\/riboflavin corneal cross-linking (CXL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Thirty-seven eyes from 37 consecutive patients with progressive keratoconus were included in this prospective observational case series. Corneal biomechanical parameters including the length of the applanated cornea (L1 and L2), corneal movement velocity during applanation (V1 and V2) at the moment of the first and second applanation, deformation amplitude (DA), distance between bending points of the cornea points of the cornea (PD), and concave radius of curvature (R) at the point of the highest concavity were recorded using the Corvis ST at baseline, 3 months, and 1 year after CXL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The mean age of the patients was 23.27 years (range, 19\u201331 years). Among CorVis ST corneal biomechanical parameters, L1, DA, PD, and R at the point of the highest concavity did not change significantly. The length of the applanated cornea at the moment of second applanation (L2) showed a significant change 3 months after CXL, but no significant difference was found between the 3-month and 1-year values of this parameter. Corneal movement velocity during applanation (V1 and V2) did not change 3 months after doing CXL, but the changes in these parameters were significant 1 year after CXL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Although the CorVis ST device may detect changes in some biomechanical properties of cornea after the treatment of keratoconus patients with CXL, many parameters remain unchanged, and this device cannot readily be used to find the effects of CXL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/joco.joco_177_21","type":"journal-article","created":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T18:38:30Z","timestamp":1717267110000},"page":"409-413","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Corneal Biomechanical Changes after Corneal Cross-Linking in Patients with Keratoconus"],"prefix":"10.4103","volume":"34","author":[{"given":"Adel","family":"Hamid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamidreza","family":"Jahadi-Hosseini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Khalili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamidreza","family":"Jahanbani-Ardakani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-4-20240910","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0039-6257(84)90094-8","article-title":"Keratoconus and related noninflammatory corneal thinning disorders","volume":"28","author":"Krachmer","year":"1984","journal-title":"Surv Ophthalmol"},{"key":"R2-4-20240910","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/00003226-199705000-00016","article-title":"Abnormalities of the extracellular matrix in keratoconus corneas","volume":"16","author":"Kenney","year":"1997","journal-title":"Cornea"},{"key":"R3-4-20240910","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1001\/archopht.1989.01070020581044","article-title":"Lysosomal enzyme abnormalities in keratoconus","volume":"107","author":"Sawaguchi","year":"1989","journal-title":"Arch Ophthalmol"},{"key":"R4-4-20240910","first-page":"751","article-title":"Collagenolytic activity in keratoconus","volume":"14","author":"Rehany","year":"1982","journal-title":"Ann Ophthalmol"},{"key":"R5-4-20240910","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/0006-291X(82)90612-X","article-title":"Increased collagenase and gelatinase activities in keratoconus","volume":"107","author":"Kao","year":"1982","journal-title":"Biochem Biophys Res Commun"},{"key":"R6-4-20240910","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0014-4835(80)80027-3","article-title":"Biomechanical properties of keratoconus and normal corneas","volume":"31","author":"Andreassen","year":"1980","journal-title":"Exp Eye Res"},{"key":"R7-4-20240910","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1755-3768.1988.tb04000.x","article-title":"Corneal elasticity and ocular rigidity in normal and keratoconic eyes","volume":"66","author":"Edmund","year":"1988","journal-title":"Acta Ophthalmol (Copenh"},{"key":"R8-4-20240910","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0014-4835(82)90040-9","article-title":"Comparison of mechanical properties of keratoconus and normal corneas","volume":"35","author":"Nash","year":"1982","journal-title":"Exp Eye Res"},{"key":"R9-4-20240910","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/02713680490513182","article-title":"Increased resistance of crosslinked cornea against enzymatic digestion","volume":"29","author":"Spoerl","year":"2004","journal-title":"Curr Eye Res"},{"key":"R10-4-20240910","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0002-9394(02)02220-1","article-title":"Riboflavin\/ultraviolet-A-induced collagen crosslinking for the treatment of keratoconus","volume":"135","author":"Wollensak","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"R11-4-20240910","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s00347-002-0700-3","article-title":"Treatment of keratoconus by collagen cross linking","volume":"100","author":"Wollensak","year":"2003","journal-title":"Ophthalmologe"},{"key":"R12-4-20240910","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1016\/S0886-3350(03)00407-3","article-title":"Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced cross-linking","volume":"29","author":"Wollensak","year":"2003","journal-title":"J Cataract Refract Surg"},{"key":"R13-4-20240910","doi-asserted-by":"crossref","first-page":"13011","DOI":"10.1074\/jbc.M110.169813","article-title":"Effects of ultraviolet-A and riboflavin on the interaction of collagen and proteoglycans during corneal cross-linking","volume":"286","author":"Zhang","year":"2011","journal-title":"J Biol Chem"},{"key":"R14-4-20240910","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1097\/01.ico.0000105827.85025.7f","article-title":"Collagen fiber diameter in the rabbit cornea after collagen crosslinking by riboflavin\/UVA","volume":"23","author":"Wollensak","year":"2004","journal-title":"Cornea"},{"key":"R15-4-20240910","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jcrs.2011.08.041","article-title":"Higher-order aberrations after corneal collagen crosslinking for keratoconus and corneal ectasia","volume":"38","author":"Greenstein","year":"2012","journal-title":"J Cataract Refract Surg"},{"key":"R16-4-20240910","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/ICO.0b013e3182a9fbdf","article-title":"Topographic, corneal wavefront, and refractive outcomes 2 years after collagen crosslinking for progressive keratoconus","volume":"33","author":"Ghanem","year":"2014","journal-title":"Cornea"},{"key":"R17-4-20240910","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.ophtha.2013.01.012","article-title":"Corneal collagen cross-linking with riboflavin and ultraviolet a irradiation for keratoconus: Long-term results","volume":"120","author":"Hashemi","year":"2013","journal-title":"Ophthalmology"},{"key":"R18-4-20240910","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1177\/1120672120944798","article-title":"Corneal biomechanical outcome of collagen cross-linking in keratoconic patients evaluated by Corvis ST","volume":"31","author":"Jabbarvand","year":"2021","journal-title":"Eur J Ophthalmol"},{"key":"R19-4-20240910","doi-asserted-by":"crossref","first-page":"4962","DOI":"10.1038\/s41598-021-84370-y","article-title":"Accuracy of new Corvis ST parameters for detecting subclinical and clinical keratoconus eyes in a Chinese population","volume":"11","author":"Ren","year":"2021","journal-title":"Sci Rep"},{"key":"R20-4-20240910","doi-asserted-by":"crossref","first-page":"15379","DOI":"10.1038\/s41598-019-51502-4","article-title":"Repeatability and comparison of new Corvis ST parameters in normal and keratoconus eyes","volume":"9","author":"Yang","year":"2019","journal-title":"Sci Rep"},{"key":"R21-4-20240910","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.joco.2017.05.002","article-title":"Keratoconus diagnosis using Corvis ST measured biomechanical parameters","volume":"29","author":"Elham","year":"2017","journal-title":"J Curr Ophthalmol"},{"key":"R22-4-20240910","doi-asserted-by":"crossref","first-page":"408","DOI":"10.3928\/1081597X-20140513-02","article-title":"Dynamic scheimpflug-based assessment of keratoconus and the effects of corneal cross-linking","volume":"30","author":"Bak-Nielsen","year":"2014","journal-title":"J Refract Surg"},{"key":"R23-4-20240910","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.jcrs.2013.12.012","article-title":"Accelerated versus conventional corneal collagen crosslinking","volume":"40","author":"Tomita","year":"2014","journal-title":"J Cataract Refract Surg"},{"key":"R24-4-20240910","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.3390\/ijerph16203872","article-title":"Topographic and biomechanical changes after application of corneal cross-linking in recurrent keratoconus","volume":"16","author":"Pedrotti","year":"2019","journal-title":"Int J Environ Res Public Health"},{"key":"R25-4-20240910","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.joco.2019.02.002","article-title":"Assessment of the changes in corneal biomechanical properties after collagen cross-linking in patients with keratoconus","volume":"31","author":"Salouti","year":"2019","journal-title":"J Curr Ophthalmol"},{"key":"R26-4-20240910","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3928\/1081597X-20151207-09","article-title":"New scheimpflug dynamic in vivo curve analyses to characterize biomechanical changes of the cornea after cross-linking for progressive keratoconus","volume":"32","author":"Steinberg","year":"2016","journal-title":"J Refract Surg"},{"key":"R27-4-20240910","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/OPX.0b013e318279eb87","article-title":"Corneal deformation measurement using Scheimpflug noncontact tonometry","volume":"90","author":"Hon","year":"2013","journal-title":"Optom Vis Sci"},{"key":"R28-4-20240910","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1167\/iovs.13-13715","article-title":"Biomechanical responses of healthy and keratoconic corneas measured using a noncontact scheimpflug-based tonometer","volume":"55","author":"Ali","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R29-4-20240910","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3928\/1081597X-20170621-03","article-title":"Comparison of corneal deformation parameters in keratoconic and normal eyes using a non-contact tonometer with a dynamic ultra-high-speed scheimpflug camera","volume":"33","author":"Mercer","year":"2017","journal-title":"J Refract Surg"}],"container-title":["Journal of Current Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/joco.joco_177_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:50:00Z","timestamp":1787770200000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/joco.joco_177_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/joco.joco_177_21","relation":{},"ISSN":["2452-2325"],"issn-type":[{"value":"2452-2325","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]}}}