{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:32:36Z","timestamp":1789623156166,"version":"build-2803163510"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the multimodal imaging of acute syphilitic posterior placoid chorioretinitis (ASPPC) lesions in order to elucidate their pathophysiology which seems to resemble choriocapillaritis as in primary inflammatory choriocapillaropathies such as multifocal choroiditis (MFC) and acute posterior multifocal placoid pigment epitheliopathy (APMPPE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Charts of patients with ASPPC seen in the Centre for Ophthalmic Specialised Care, Lausanne, Switzerland, were retrieved. Fundus autofluorescence (FAF), spectral domain optical coherence tomography (SD-OCT), fluorescein angiography (FA), indocyanine green angiography (ICGA), and when available, OCT angiography were analyzed and compared to a case of MFC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>One woman aged 58 and 2 men aged 50 and 31 with unilateral ASPPC were analyzed. All had positive syphilis serologies (venereal disease research laboratory [VDRL] and treponema Pallidum hemagglutination assay [TPHA]). Two were human immunodeficiency virus (HIV) positive. Mean best corrected visual acuity was 0.2 \u00b1 0.1 at presentation and 1.0 for all patients 6 weeks later, after antibiotic treatment for neurosyphilis. All had central scotomata with a mean defect (MD) of 12.2 \u00b1 2.6. Six weeks later, MD values were 3.9 \u00b1 1.7. Microperimetry had a mean score of 25\/560 at presentation and recovered to a mean of 444\/560 6 weeks later. Multimodal imaging features consisted of FA tissue staining, ICGA hypofluorescent choriocapillaris non-perfusion, FAF hyperautofluorescence, and loss of the ellipsoid line in the diseased areas. The findings were consistent and identical in ASPPC and a case of MFC and pointed toward the involvement of the choriocapillaris.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Similarities seen in multimodal imaging features in ASPPC and choriocapillaritis highlight the role of the choriocapillaris in the pathophysiologic mechanism of both conditions. Inflammatory choriocapillaris non-perfusion triggered by infectious agents seems to be the common pathway through which the eye is reacting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/joco.joco_184_20","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T08:48:17Z","timestamp":1611737297000},"page":"381-389","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":21,"title":["Choriocapillaris Involvement in Acute Syphilis Posterior Placoid Chorioretinitis Is Responsible for Functional Impairment and Points Towards An Immunologic Mechanism"],"prefix":"10.4103","volume":"32","author":[{"given":"Carl P","family":"Herbort","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Papasavvas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Mantovani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-12-20240910","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/S0161-6420(90)32418-1","article-title":"Acute syphilitic posterior placoid chorioretinitis","volume":"97","author":"Gass","year":"1990","journal-title":"Ophthalmology"},{"key":"R2-12-20240910","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1001\/archopht.1968.00980050179005","article-title":"Acute posterior multifocal placoid pigment epitheliopathy","volume":"80","author":"Gass","year":"1968","journal-title":"Arch Ophthalmol"},{"key":"R3-12-20240910","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/0002-9394(77)90380-4","article-title":"Choriocapillaris nonperfusion in acute multifocal placoid pigment epitheliopathy","volume":"84","author":"Deutman","year":"1977","journal-title":"Am J Ophthalmol"},{"key":"R4-12-20240910","first-page":"790","article-title":"Choroidal hypoperfusion in acute posterior multifocal placoid pigment epitheliopathy","volume":"102","author":"Howe","year":"1995","journal-title":"An indocyanine green angiography study. 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Why this question has to be dealt with separately from other eye conditions","volume":"32","author":"Herbort","year":"2012","journal-title":"Retina"},{"key":"R8-12-20240910","doi-asserted-by":"crossref","first-page":"e550","DOI":"10.1111\/aos.12150","article-title":"Secondary choriocapillaritis in infectious chorioretinitis","volume":"91","author":"Knecht","year":"2013","journal-title":"Acta Ophthalmol"},{"key":"R9-12-20240910","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1097\/ICB.0000000000000645","article-title":"Multimodal imaging adds new insights into acute syphilitic posterior placoid chorioretinitis","volume":"12","author":"Tsui","year":"2018","journal-title":"Retin Cases Brief Rep"},{"key":"R10-12-20240910","doi-asserted-by":"crossref","first-page":"100678","DOI":"10.1016\/j.ajoc.2020.100678","article-title":"Widefield swept source OCT angiography in acute syphilitic placoid chorioretinitis","volume":"18","author":"Barikian","year":"2020","journal-title":"Am J Ophthalmol Case Rep"},{"key":"R11-12-20240910","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/01.iae.0000242759.80833.39","article-title":"Autofluorescence imaging of acute syphilitic posterior placoid chorioretinitis","volume":"1","author":"Matsumoto","year":"2007","journal-title":"Retin Cases Brief Rep"},{"key":"R12-12-20240910","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1097\/IAE.0b013e31825f3851","article-title":"International Syphilis Study Group. Acute syphilitic posterior placoid chorioretinitis: A report of a case series and comprehensive review of the literature","volume":"32","author":"Eandi","year":"2012","journal-title":"Retina"},{"key":"R13-12-20240910","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/00006982-200502000-00010","article-title":"Indocyanine green angiography anomalies in ocular syphilis","volume":"25","author":"Mora","year":"2005","journal-title":"Retina"},{"key":"R14-12-20240910","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1007\/s00347-019-01012-5","article-title":"White dot syndromes: Principles, diagnostics, and treatment","volume":"116","author":"Pohlmann","year":"2019","journal-title":"Ophthalmologe"},{"key":"R15-12-20240910","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3928\/23258160-20151214-03","article-title":"Choroidal involvement in acute posterior multifocal placoid pigment epitheliopathy","volume":"47","author":"Mrejen","year":"2016","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"key":"R16-12-20240910","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1076\/ocii.8.4.275.6462","article-title":"Sensitivity of indocyanine green angiography for the follow-up of active inflammatory choriocapillaropathies","volume":"8","author":"Cimino","year":"2000","journal-title":"Ocul Immunol Inflamm"},{"key":"R17-12-20240910","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1007\/s00417-015-3205-x","article-title":"Interpretation of fundus autofluorescence changes in choriocapillaritis: A multi-modality imaging study","volume":"254","author":"Mantovani","year":"2016","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"R19-12-20240910","first-page":"67","article-title":"A case of overlapping choriocapillaritis syndromes: Multimodal imaging appraisal","volume":"7","author":"Kuznetcova","year":"2012","journal-title":"J Ophthalmic Vis Res"},{"key":"R21-12-20240910","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.ajo.2014.08.039","article-title":"Success with single-agent immunosuppression for multifocal choroidopathies","volume":"158","author":"Goldberg","year":"2014","journal-title":"Am J Ophthalmol"}],"container-title":["Journal of Current Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/JOCO.JOCO_184_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:37:54Z","timestamp":1787845074000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/JOCO.JOCO_184_20"}},"subtitle":["A Comprehensive Clinicopathological Approach"],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.4103\/joco.joco_184_20","relation":{},"ISSN":["2452-2325"],"issn-type":[{"value":"2452-2325","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]}}}