{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:36:46Z","timestamp":1788781006395,"version":"build-2803163510"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To investigate the choroidal structure in keratoconic patients with different severity using the choroidal vascularity index (CVI) derived from image binarization on enhanced depth imaging optical coherence tomography scans (EDI-OCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Sixty-eight eyes from 34 keratoconus (KCN) patients and 72 eyes from 36 healthy subjects were recruited in this prospective, noninterventional, comparative cross-sectional study. EDI-OCT was employed to measure choroidal parameters, including choroidal thickness (CT), total choroidal area (TCA), luminal area, stromal area, and CVI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Subfoveal CT was 354.6 \u00b1 66.8 mm in the control group and 371 \u00b1 64.5 mm in the KCN group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.86). There was no significant difference between control and KCN groups in terms of TCA (0.66 \u00b1 0.14 mm\n                      <jats:sup>2<\/jats:sup>\n                      vs. 0.7 \u00b1 0.12 mm\n                      <jats:sup>2<\/jats:sup>\n                      ;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.70), luminal area (0.49 \u00b1 0.10 mm\n                      <jats:sup>2<\/jats:sup>\n                      vs. 0.53 \u00b1 0.08 mm\n                      <jats:sup>2<\/jats:sup>\n                      ;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.67), and stromal area (0.16 \u00b1 0.05 mm\n                      <jats:sup>2<\/jats:sup>\n                      vs. 0.17 \u00b1 0.05 mm\n                      <jats:sup>2<\/jats:sup>\n                      ;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.84). CVI was also comparable in the control group (75.4% \u00b13.4%) and the KCN group (75.6% \u00b14.5%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.43). There was also no significant correlation between other choroidal parameters and KCN severity indices.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>It seems that CVI as well as other choroidal biomarkers were not significantly different between patients with KCN and healthy subjects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/joco.joco_189_22","type":"journal-article","created":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T18:32:03Z","timestamp":1717266723000},"page":"36-41","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of Choroidal Vascularity Index in Keratoconus Patients: Does Choroidal Vascularity Change in Keratoconus?"],"prefix":"10.4103","volume":"35","author":[{"given":"Mohammad Naser","family":"Hashemian","sequence":"first","affiliation":[{"name":"Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadegh","family":"Ghafarian","sequence":"additional","affiliation":[{"name":"Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Riazi-Esfahani","sequence":"additional","affiliation":[{"name":"Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Khalili Pour","sequence":"additional","affiliation":[{"name":"Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, 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