{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:22:55Z","timestamp":1787757775939,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To study the potential of dark-field scanning laser ophthalmoscopy (DF-SLO) for the prediction of central serous chorioretinopathy (CSC) responsiveness to laser therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Fifty-two eyes of 52 patients (44 males and 8 females, mean age of 45.4 \u00b1 8.8 years) newly diagnosed with CSC were included in this prospective cohort study. At baseline, all patients received multimodal imaging including DF-SLO and then were observed until resolution of subretinal fluid or, in nonresolving cases, treated with laser therapy. At the end of the follow-up, each case was categorized as either self-resolving, resolving after laser treatment, or nonresolving after laser treatment. Presence of granular retinal pigment epithelium (RPE) changes and lucency of RPE\/choroid complex at the leak on DF-SLO images were used by two masked graders to identify cases nonresolving after laser treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Using DF-SLO images, the masked grader correctly classified 45 of 52 (86.5%) CSC cases. Kappa value for the classification by two graders was 0.95 (95% confidential interval [CI] 0.85\u20131.0). The area under the receiver operating curve, sensitivity, and specificity of DF-SLO in identifying nonresolving after laser treatment cases were 0.92 (95% CI: 0.79\u20130.98), 86.7% (95% CI: 59.5%\u201398.3%), and 96.6% (95% CI: 82.2%\u201399.2%), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>DF-SLO may be a useful technique in prognostication of response to laser treatment in newly diagnosed CSC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/joco.joco_257_21","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T01:10:45Z","timestamp":1641431445000},"page":"461-467","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Dark-Field Scanning Laser Ophthalmoscopy for Prediction of Central Serous Chorioretinopathy Responsiveness to Laser Therapy"],"prefix":"10.4103","volume":"33","author":[{"given":"Alexei N.","family":"Kulikov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitrii S.","family":"Maltsev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Burnasheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Chhablani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-15-20240910","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1038\/s41433-020-0774-7","article-title":"Axial length as a basic anatomical predictor for morphological and clinical characteristics in acute central serous chorioretinopathy","volume":"34","author":"Maltsev","year":"2020","journal-title":"Eye 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Sci"},{"key":"R11-15-20240910","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0042-6989(96)00120-4","article-title":"Near infrared light absorption in the human eye media","volume":"37","author":"van den Berg","year":"1997","journal-title":"Vision Res"},{"key":"R12-15-20240910","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1364\/AO.20.002184","article-title":"Melanin a unique biological absorber","volume":"20","author":"Wolbarsht","year":"1981","journal-title":"Appl Opt"}],"container-title":["Journal of Current 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