{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:19:20Z","timestamp":1787750360786,"version":"build-2784847793"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the effects of pars plana vitrectomy (PPV) versus panretinal photocoagulation (PRP) on ocular blood flow in patients with proliferative diabetic retinopathy (PDR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The blood flow parameters of the ophthalmic artery (OA), central retinal artery (CRA), central retinal vein (CRV), and posterior ciliary artery (PCA) of patients with PDR were evaluated with color Doppler ultrasonography (CDU), before and 6 months after PPV and PRP in 24 eyes of 24 patients. PRP alone was applied in the laser group, whereas PPV and PRP were applied to patients in the vitrectomy group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      CRA\u2019s peak systolic velocity, end-diastolic velocity, and CRV\u2019s mean velocity were significantly lower after PRP (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003, and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.050, respectively). A significant reduction in the resistivity index of CRA (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.005) and OA (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.013) was found in the vitrectomy group after PPV. Despite the application of PRP in the vitrectomy group, the decrease in postoperative flow velocities of the CRA, CRV, and PCA were lower than in the laser group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>PRP treatment was associated with reduced flow velocities in the CRA and CRV; however, no comparable decline was observed when PPV was combined with PRP. Our findings suggest that PPV may counteract the flow-reducing effects of PRP by enhancing ocular blood flow velocities and decreasing vascular resistance. Given the limited sample size, this investigation should be considered a preliminary pilot study without definitive clinical conclusions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/joco.joco_265_24","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T11:00:48Z","timestamp":1782126048000},"page":"430-435","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["The Effects of Pars Plana Vitrectomy and Panretinal Laser Photocoagulation on Ocular Blood Flow in Proliferative Diabetic Retinopathy"],"prefix":"10.4103","volume":"37","author":[{"given":"Mehmet Bar\u0131\u015f","family":"\u00dc\u00e7er","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Sincan Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeliha","family":"Yazar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Health Sciences Ankara City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"\u00d6nen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Health Sciences Ankara City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutlu","family":"G\u00fclbay","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Health Sciences Ankara City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"R1-20260623","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.ophtha.2021.04.027","article-title":"Global prevalence of diabetic retinopathy and projection of burden through 2045: Systematic review and meta-analysis","volume":"128","author":"Teo","year":"2021","journal-title":"Ophthalmology"},{"key":"R2-20260623","first-page":"629","article-title":"Evaluation of hemodynamic changes in retrobulbar blood vessels using color Doppler \u0131maging in diabetic patients","volume":"12","author":"Madhpuriya","year":"2022","journal-title":"Life (Basel)"},{"key":"R3-20260623","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.4103\/ijo.IJO_1398_19","article-title":"Evaluation of retrobulbar circulation in type 2 diabetic patients using color Doppler imaging","volume":"68","author":"Divya","year":"2020","journal-title":"Indian J Ophthalmol"},{"key":"R4-20260623","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4103\/JMU.JMU_88_20","article-title":"Evaluation of resistive \u0131ndex of orbital vessels using color Doppler \u0131maging in patients with type 2 diabetes mellitus","volume":"29","author":"Kanagaraju","year":"2021","journal-title":"J Med Ultrasound"},{"key":"R5-20260623","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s11892-021-01403-6","article-title":"Laser therapy in the treatment of diabetic retinopathy and diabetic macular edema","volume":"21","author":"Everett","year":"2021","journal-title":"Curr Diab Rep"},{"key":"R6-20260623","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/S0161-6420(92)31779-8","article-title":"Pars plana vitrectomy in the early treatment diabetic retinopathy study. 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