{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:32:31Z","timestamp":1787758351293,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To report a case of ciliary body melanoma with acute high intraocular pressure (IOP) due to pigment dispersion, treated by limited trans-scleral cyclophotocoagulation (TSCPC) and plaque radiotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A 33-year-old woman was referred to clinic with acute ocular pain and decreased visual acuity from 1 week before presentation. The IOP was 55 mmHg accompanied by red eye, perilimbal injection, mild corneal edema (stromal and epithelial), scattered pigment dust on central corneal endothelium, 4\n                      <jats:sup>+<\/jats:sup>\n                      anterior chamber pigments, and pigmented cells. Gonioscopy revealed a bulging mass posterior to the iris root, about 2 o'clock width alongside a heavy dark brown pigmentation of all angle structures. Ultrasound biomicroscopy confirmed a ciliary body mass of about 4.5 mm \u00d7 4 mm \u00d7 3.3 mm in the superior ciliary region, in favor of melanoma. Due to no response to maximal antiglaucoma therapy, a limited TSCPC in the inferior hemisclera was done. After control of the IOP, plaque radiotherapy with Ru-106 was done.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Three days after the cyclophotocoagulation, IOP decreased to 18 mmHg. Visual acuity reached to 20\/25 and IOP remained 18 mmHg, with timolol\/dorzolamide drop twice a day. Anterior chamber pigments gradually decreased, and antiglaucoma and steroid drops were tapered during 1 month, thereafter. The IOP was 14\u201316 mmHg with timolol\/dorzolamide bid at months 3 and 6 of follow-up and 21\u201322 mmHg without any drop at months 12 and 18, with no sign of glaucomatous optic neuropathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Limited cyclophotocoagulation may be a good choice for controlling the high refractory IOP in cases of intraocular neoplasms such as ciliary body melanoma, which are planned for salvage therapy such as plaque radiotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/joco.joco_269_21","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T15:02:58Z","timestamp":1661439778000},"page":"118-120","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Trans-Scleral Cyclophotocoagulation in Refractory Pigment Dispersion-Like Glaucoma Secondary to Ciliary Body Melanoma"],"prefix":"10.4103","volume":"34","author":[{"given":"Mohammad","family":"Banifatemi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveed","family":"Nilforushan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahad","family":"Sedaghat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arezoo","family":"Miraftabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navid","family":"Abolfathzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-19-20240910","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.hoc.2012.08.004","article-title":"Epidemiology and management of uveal melanoma","volume":"26","author":"Yonekawa","year":"2012","journal-title":"Hematol Oncol Clin North Am"},{"key":"R2-19-20240910","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/eye.2016.275","article-title":"Uveal melanoma: Relatively rare but deadly cancer","volume":"31","author":"Kaliki","year":"2017","journal-title":"Eye (Lond"},{"key":"R3-19-20240910","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/cxo.12610","article-title":"Ciliary body melanoma manifesting as unilateral ocular hypertension and early cataract","volume":"101","author":"Siempis","year":"2018","journal-title":"Clin Exp Optom"},{"key":"R4-19-20240910","doi-asserted-by":"crossref","first-page":"e191","DOI":"10.1016\/j.jfo.2013.01.016","article-title":"Ciliary body melanoma presenting as uveitis in a West Indian woman: Case report and review of the literature","volume":"36","author":"Diwo","year":"2013","journal-title":"J Fr Ophtalmol"},{"key":"R5-19-20240910","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0161-6420(87)33537-7","article-title":"Prevalence and mechanisms of secondary intraocular pressure elevation in eyes with intraocular tumors","volume":"94","author":"Shields","year":"1987","journal-title":"Ophthalmology"},{"key":"R6-19-20240910","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/ICU.0000000000000550","article-title":"Glaucoma secondary to intraocular tumors: Mechanisms and management","volume":"30","author":"Camp","year":"2019","journal-title":"Curr Opin Ophthalmol"},{"key":"R7-19-20240910","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1001\/jamaophthalmol.2013.828","article-title":"Inadvertent implantation of aqueous tube shunts in glaucomatous eyes with unrecognized intraocular neoplasms: Report of 5 cases","volume":"131","author":"Kaliki","year":"2013","journal-title":"JAMA Ophthalmol"},{"key":"R8-19-20240910","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0008-4182(05)80120-6","article-title":"Subconjunctival spread of ciliary body melanoma after glaucoma filtering surgery: A clinicopathological case report","volume":"40","author":"Pasternak","year":"2005","journal-title":"Can J Ophthalmol"}],"container-title":["Journal of Current Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/joco.joco_269_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:11:01Z","timestamp":1787757061000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/joco.joco_269_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/joco.joco_269_21","relation":{},"ISSN":["2452-2325"],"issn-type":[{"value":"2452-2325","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}