{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:52:37Z","timestamp":1792443157375,"version":"4.5.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate and compare optical coherence tomography angiography (OCTA) retinal vasculature measurements in healthy, glaucoma suspect (GS), and glaucoma patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>One hundred fourteen eyes with good quality OCTA pictures were included from 38 healthy, 38 GS, 38 and primary open-angle glaucoma (POAG) participants. The information on retinal vasculature was summarized as a vessel density map and as vessel density (%), which is the fraction of the flowing vessel area over the total area examined. The superior, inferior, nasal, and temporal quadrants, as well as whole vessel density (wVD) and peripapillary vessel density (ppVD) data taken from the retinal nerve fiber layer, were studied. Global indices of the visual field were correlated with vessel density measurement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Mean vessel density was significantly lower in POAG eyes compared with GSs and healthy eyes (wVD) 45.34% \u00b1 6.64%, 50.06% \u00b1 1.97% and 53.06% \u00b1 2.12%, respectively (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), and ppVD 47.42% \u00b1 7.73%, 47.42% \u00b1 7.73% and 56.074% \u00b1 2.71%, respectively (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). A linear relationship between vessel density (wVD and ppVD) and global indices of the visual field (mean deviation [MD] and pattern standard deviation [PSD]) shows a significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) relation.\n                      <jats:italic toggle=\"yes\">R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      is 0.35, 0.36, 0.36, and 0.33 for MD and wVD, PSD and wVD, PSD and ppVD, and MD and ppVD, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>For distinguishing between healthy and glaucoma eyes, OCTA vessel density demonstrated near similar diagnostic accuracy to visual field tests. These findings imply that OCTA measurements reflect damage to tissues important in the pathogenesis of POAG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/joco.joco_270_23","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T11:05:51Z","timestamp":1729076751000},"page":"31-36","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Optical Coherence Tomography Angiography Vessel Density in Healthy, Glaucoma Suspect, and Glaucoma Eyes"],"prefix":"10.4103","volume":"36","author":[{"given":"Umesh","family":"Belbase","sequence":"first","affiliation":[{"name":"Department of Optometry, Himalaya Eye Hospital, Gharipatan, Pokhara, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indra Man","family":"Maharjan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Himalaya Eye Hospital, Gharipatan, Pokhara, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anup","family":"Subedi","sequence":"additional","affiliation":[{"name":"Department of Optometry, Himalaya Eye Hospital, Gharipatan, Pokhara, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,10,16]]},"reference":[{"key":"R1-20241018","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/S0140-6736(10)61423-7","article-title":"Glaucoma","volume":"377","author":"Quigley","year":"2011","journal-title":"Lancet"},{"key":"R2-20241018","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1001\/archopht.120.6.701","article-title":"The ocular hypertension treatment study","volume":"120","author":"Miller","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"R3-20241018","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.ophtha.2005.06.020","article-title":"Results of the European glaucoma prevention study","volume":"112","author":"Miglior","year":"2005","journal-title":"Ophthalmology"},{"key":"R4-20241018","first-page":"611","article-title":"Strategies for improving early detection of glaucoma:The combined structure-function index","volume":"8","author":"Tatham","year":"2014","journal-title":"Clin Ophthalmol"},{"key":"R5-20241018","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0039-6257(05)80042-6","article-title":"Mechanisms of optic nerve damage in primary open angle glaucoma","volume":"39","author":"Fechtner","year":"1994","journal-title":"Surv Ophthalmol"},{"key":"R6-20241018","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/0039-6257(94)90041-8","article-title":"The vascular concept of glaucoma","volume":"38","author":"Flammer","year":"1994","journal-title":"Surv Ophthalmol"},{"key":"R7-20241018","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0161-6420(00)00138-X","article-title":"Vascular risk factors for primary open angle glaucoma:The Egna-Neumarkt study","volume":"107","author":"Bonomi","year":"2000","journal-title":"Ophthalmology"},{"key":"R8-20241018","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0161-6420(94)31303-0","article-title":"Adverse reactions due to indocyanine green","volume":"101","author":"Hope-Ross","year":"1994","journal-title":"Ophthalmology"},{"key":"R9-20241018","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S1081-1206(10)63140-7","article-title":"Fluorescein-induced allergic reaction","volume":"81","author":"L\u00f3pez-S\u00e1ez","year":"1998","journal-title":"Ann Allergy Asthma Immunol"},{"key":"R10-20241018","doi-asserted-by":"crossref","first-page":"OCT27","DOI":"10.1167\/iovs.15-19043","article-title":"Optical coherence tomography angiography","volume":"57","author":"Gao","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R11-20241018","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1364\/BOE.3.003127","article-title":"Quantitative OCT angiography of optic nerve head blood flow","volume":"3","author":"Jia","year":"2012","journal-title":"Biomed Opt Express"},{"key":"R12-20241018","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1001\/jamaophthalmol.2016.5327","article-title":"Evaluation of segmentation of the superficial and deep vascular layers of the retina by optical coherence tomography angiography instruments in normal eyes","volume":"135","author":"Spaide","year":"2017","journal-title":"JAMA Ophthalmol"},{"key":"R13-20241018","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1136\/bjo.52.1.26","article-title":"Radial peripapillary capillaries of the retina. 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