{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:03:18Z","timestamp":1791838998751,"version":"4.3.4"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the potential choroidal vascular changes in newly diagnosed subclinical Cushing syndrome (SCS) patients and to assess whether choroidal parameters correlate with hormonal parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Twenty-one right eyes of 21 patients with SCS and 22 right eyes of 22 healthy individuals were included in the study. Results of the 1 mg dexamethasone suppression test, basal cortisol, basal adrenocorticotropic hormone, and 24-h urine-free cortisol levels were recorded from the patient files. Choroidal thicknesses (CTs) were measured from the subfoveal, 500 \u03bcm nasal, and 500 \u03bcm temporal quadrants with enhanced depth imaging-optical coherence tomography (OCT). The ImageJ program calculated the choroidal vascularity index (CVI). The choriocapillaris (CC) flow area was evaluated with OCT-angiography. The primary outcome measure was the CVI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were no significant differences in subfoveal, nasal, or temporal CT between groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05). In addition, there was no statistically significant difference between the SCS group and the control group in terms of total choroidal area, luminal area, stromal area, and CVI values (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.827,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.466,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.343, and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.065, respectively). The mean difference in subfoveal CVI between the groups was \u22121.78 (95% confidence interval: \u22123.8\u20130.2). No statistical difference was found between the SCS and control groups in terms of CC flow area, with a radius of 1, 2, and 3 mm (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05). No statistically significant correlation was detected between the examined choroidal and biochemical parameters (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>According to the results of this study, subclinical hormonal changes in newly diagnosed SCS patients do not affect choroidal vascular status.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/joco.joco_271_25","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T14:42:02Z","timestamp":1786027322000},"page":"42-49","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Choroidal Vascular Characteristics in Subclinical Cushing Syndrome: A Cross-Sectional Pilot Study using Enhanced Depth Imaging Optical Coherence Tomography and Optical Coherence Tomography Angiography"],"prefix":"10.4103","volume":"38","author":[{"given":"Eyupcan","family":"Sensoy","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Health Sciences, Ankara Etlik City Hospital, Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berrak","family":"Sekeryapan Gediz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Health Sciences, Ankara Etlik City Hospital, Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevde Nur","family":"Firat","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Ankara Training and Research Hospital, Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinar","family":"Cicek Kaya","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Health 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