{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:30:22Z","timestamp":1786649422948,"version":"build-2736575974"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To report the outcome of a ciliary body medulloepithelioma associated with DICER-1 syndrome treated with iodine-125 plaque brachytherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>An 11-year-old male with a DICER1 gene mutation, who was previously treated for pineoblastoma with craniospinal radiotherapy and systemic chemotherapy at the age of three, was referred to assess a vascularized retrolental mass in his left eye. The clinical and ultrasound evaluations, besides his initial diagnosis of DICER-1 syndrome, suggested a ciliary body medulloepithelioma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>No biopsy was performed given the risks of hemorrhage and tumor cell dissemination. The patient underwent iodine-125 plaque brachytherapy. Although the patient developed a radiation-induced cataract, it was eventually treated with cataract surgery. Five years after brachytherapy, the patient maintained excellent visual acuity with no signs of tumor recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Plaque brachytherapy is effective in achieving long-term control of DICER1-associated medulloepithelioma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/joco.joco_30_25","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T14:00:59Z","timestamp":1766152859000},"page":"263-265","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Plaque Brachytherapy for DICER1-Associated Ciliary Body Medulloepithelioma"],"prefix":"10.4103","volume":"37","author":[{"given":"Mojtaba","family":"Abrishami","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Vision Sciences, Ocular Oncology Service, Princess Margaret Cancer Center\/University Health Network, University of Toronto, Toronto, Canada"},{"name":"Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akbar","family":"Beiki-Ardakani","sequence":"additional","affiliation":[{"name":"Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatem","family":"Krema","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Sciences, Ocular Oncology Service, Princess Margaret Cancer Center\/University Health Network, University of Toronto, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"R1-20251222","doi-asserted-by":"crossref","first-page":"755","DOI":"10.4103\/ijo.IJO_845_19","article-title":"Intraocular medulloepithelioma \u2013 A review of clinical features, DICER 1 mutation, and management","volume":"67","author":"Tadepalli","year":"2019","journal-title":"Indian J Ophthalmol"},{"key":"R2-20251222","first-page":"30","article-title":"Plaque radiotherapy for medulloepithelioma in 6 cases from a single center","volume":"8","author":"Ang","year":"2019","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"key":"R3-20251222","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ajoc.2018.06.019","article-title":"Successful treatment of metastatic congenital intraocular medulloepithelioma with neoadjuvant chemotherapy, enucleation and superficial parotidectomy","volume":"11","author":"Hellman","year":"2018","journal-title":"Am J Ophthalmol Case Rep"},{"key":"R4-20251222","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1159\/000443963","article-title":"On the classification and grading of medulloepithelioma of the eye","volume":"2","author":"Verdijk","year":"2016","journal-title":"Ocul Oncol Pathol"},{"key":"R5-20251222","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/MPH.0000000000000715","article-title":"Multimorbidity and genetic characteristics of DICER1 syndrome based on systematic review","volume":"39","author":"Cai","year":"2017","journal-title":"J Pediatr Hematol Oncol"},{"key":"R6-20251222","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1016\/j.ophtha.2013.05.015","article-title":"Ciliary body medulloepithelioma: Analysis of 41 cases","volume":"120","author":"Kaliki","year":"2013","journal-title":"Ophthalmology"},{"key":"R7-20251222","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.oftal.2016.11.011","article-title":"Outcomes and complications after phacoemulsification in retinoblastoma patients with cataract after radiation treatment","volume":"92","author":"Vel\u00e1squez-Aguilar","year":"2017","journal-title":"Arch Soc Esp Oftalmol"}],"container-title":["Journal of Current Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/joco.joco_30_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:54:00Z","timestamp":1786647240000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/joco.joco_30_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/joco.joco_30_25","relation":{},"ISSN":["2452-2325"],"issn-type":[{"value":"2452-2325","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2025-01-30","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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