{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:48:53Z","timestamp":1787071733061,"version":"build-2736575974"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"Abstract<\/jats:title>\n \n Purpose:<\/jats:title>\n To evaluate the safety and efficacy of increased environmental oxygen using a novel oxygen chamber during corneal cross-linking (CXL) in patients with keratoconus (KCN).<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n This prospective interventional pilot study included 20 eyes from 15 patients with documented progressive KCN. Patients underwent epithelium-off accelerated CXL (irradiance of 9 mW\/cm\u00b2 for 10 min) in two different environments. The study group received CXL using an oxygen chamber providing a high-oxygen environment (60%), while the control group underwent CXL under ambient oxygen conditions (21%). Outcome measures included visual and topographic outcomes, demarcation line depth, endothelial cell count, and dry eye evaluation. Follow-up visits were conducted up to 6 months post-CXL.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Seventeen eyes completed the follow-up (study: 10 and control: 7). At 1-month postoperation, the study group exhibited a significantly deeper demarcation line, particularly at the inferior 3 mm location (250.8 \u03bcm vs. 169.3 \u03bcm,\n P<\/jats:italic>\n = 0.03). At 6 months post-CXL, keratometry values improved more in the study group, with K\n 1<\/jats:sub>\n and K\n m<\/jats:sub>\n showing a significant decrease from baseline (\n P<\/jats:italic>\n = 0.046 and 0.047, respectively). Best-corrected visual acuity and refraction remained stable in both groups throughout the 6-month follow-up (\n P<\/jats:italic>\n > 0.05). The endothelial cell count decreased less in the study group compared to the control group (\u2212136.1 \u00b1 52.3 vs. \u2212288.9 \u00b1 100.9,\n P<\/jats:italic>\n = 0.16).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The findings of this pilot study show that the novel oxygen chamber can safely and effectively enhance CXL outcomes by creating a hyperoxic environment.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/joco.joco_38_25","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T15:00:23Z","timestamp":1763132423000},"page":"61-68","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Oxygen Chamber for Corneal Cross-Linking in a High-Oxygen Environment: A Pilot Study and Clinical Outcomes"],"prefix":"10.4103","volume":"37","author":[{"given":"Fateme","family":"Alipour","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidar","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bailey Elizabeth","family":"Kealamakia","sequence":"additional","affiliation":[{"name":"Department of Mathematics, University of Utah, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Ashrafi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Hafezi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, ELZA Institute, Zurich, Switzerland"},{"name":"Department of Ophthalmology, CABMM, University of Zurich, Zurich, Switzerland"},{"name":"Department of Ophthalmology, Medical Faculty, University of Geneva, Geneva, Switzerland"},{"name":"Department of Ophthalmology, Medical University Wenzhou, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Houshang","family":"Beheshtnejad","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Ghaffari","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shima","family":"Dehghani","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, John A. 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