{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:22:50Z","timestamp":1787847770607,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To determine the changes in serum levels of free vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), and growth parameters in infants with retinopathy of prematurity (ROP) who received intravitreal injection of the bevacizumab (IVB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A prospective interventional case series study, including 10 infants with Type 1 ROP was conducted. Using the enzyme-linked immunosorbent assay, serum levels of VEGF and IGF-1 were measured before, 1 month and 2 months after treatment with IVB in both eyes. Growth parameters, including weight, length, and head circumference and their Fenton's z-score, were also measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Serum VEGF levels were suppressed 1 month after IVB (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.007) and then increased between 1 and 2 months (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.064). Z-scores of all growth parameters except weight z-score decreased in the 1\n                      <jats:sup>st<\/jats:sup>\n                      and 2\n                      <jats:sup>nd<\/jats:sup>\n                      months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Serum VEGF levels showed a transient reduction after IVB which lasted at least 2 months. Growth velocity of premature infants may be affected by anti-VEGF therapy and should be followed with particular attention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/joco.joco_78_20","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T02:09:15Z","timestamp":1610417355000},"page":"159-163","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["The Short-Term Effects of Intravitreal Injection of Bevacizumab on the Plasma Levels of Vascular Endothelial Growth Factor, Insulin-Like Growth Factor-1, and Growth Parameters in Infants with Retinopathy of Prematurity"],"prefix":"10.4103","volume":"32","author":[{"given":"Ahad","family":"Sedaghat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parya","family":"Abdolalizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Mehdi","family":"Parvaresh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajad","family":"Ghorbanizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parisa","family":"Mohagheghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaveh Abri","family":"Aghdam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20240910","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1136\/bjophthalmol-2016-308828","article-title":"The association between systemic vascular endothelial growth factor and retinopathy of prematurity in premature infants: A systematic review","volume":"101","author":"Kandasamy","year":"2017","journal-title":"Br J Ophthalmol"},{"key":"R2-6-20240910","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/apa.13350","article-title":"Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development","volume":"105","author":"Hellstr\u00f6m","year":"2016","journal-title":"Acta Paediatr"},{"key":"R3-6-20240910","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1056\/NEJMoa1007374","article-title":"Efficacy of intravitreal bevacizumab for Stage 3+ retinopathy of 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