{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:05:37Z","timestamp":1792728337803,"version":"4.5.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The oral wound healing is dependent of immune participation and the absence or augment of one specific immune profile can delayed wound healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>So, the objective of this study was t evaluate the wound healing of oral traumatic ulcer (OTU) in cheek mucosa of swiss, balb\/c and c57bl6J mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      A total of 144 mice (25-30g) were distributed in three groups: swiss (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 48), balb\/c (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 48) and c57bl\/6j (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 48). An OTU was performed using a dermatological punch in left cheek mucosa. The animals were euthanized daily (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 6\/group\/day by 8 days) for evaluation of the ulcer area, weight loss and histological analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There are no differences between ulcer area in three groups; however only swiss group showed total wound healing. Swiss group showed weight loss in 2\n                      <jats:sup>nd<\/jats:sup>\n                      and 3\n                      <jats:sup>rd<\/jats:sup>\n                      days recovering the body mass in 4\n                      <jats:sup>th<\/jats:sup>\n                      day (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01). Balb\/c group showed the greater weight loss (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05) and c57bl\/6j did not show body mass variation (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.258). Histologically swiss group was the only group that showed total reepithelization (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Balb\/c (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.022) and c57bl\/6j (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) showed decrease in histological scores, chronic inflammation on the 8\n                      <jats:sup>th<\/jats:sup>\n                      day. Actinomyces was significantly more observed in surface of OTU of balb\/c.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Balb\/c mice showed high infection of OTU surface delaying wound healing, and greater weight loss. C57bl\/6J mice showed low infection of OTU, but not healing along the eight days. Only the Swiss mice showed wound healing of OTU.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jomfp.jomfp_144_17","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T07:07:35Z","timestamp":1592982455000},"page":"444-444","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":17,"title":["Experimental model of oral ulcer in mice: Comparing wound healing in three immunologically distinct animal lines"],"prefix":"10.4103","volume":"22","author":[{"given":"Paulo Goberl\u00e2nio de Barros","family":"Silva","sequence":"first","affiliation":[{"name":"Department of Dentistry, Unichristus, Fortaleza, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9rian Bezerra Belo de","family":"Codes","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Unichristus, Fortaleza, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena Oliveira","family":"Freitas","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Unichristus, Fortaleza, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce Ohana de Lima","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Unichristus, Fortaleza, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula Negreiros Nunes","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Dental Clinic, Sector of Oral Pathology, Universidade Federal Do Cear\u00e1, Fortaleza, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabr\u00edcio Bitu","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Unichristus, Fortaleza, Cear\u00e1, Brazil"},{"name":"Department of Dental Clinic, Sector of Oral Pathology, Universidade Federal Do Cear\u00e1, Fortaleza, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250921","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1067\/moe.2000.104476","article-title":"Insulin-dependent diabetes mellitus and oral soft tissue pathologies. 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