{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:10:54Z","timestamp":1790403054837,"version":"4.1.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Unfavorable modifications of tooth and its surrounding structures result in periodontal complications. Viruses, in specific herpes virus, are known to increase disease severity in periodontal patients. Periodontitis is known to be more established in type 2 diabetes mellitus (DM2) patients. Hence, the detection of the viral load, its effect on the prevalence of periodontitis and the glycemic control status of patients are to be evidenced. The study aimed to reveal the association of herpes virus with periodontal parameters and its prevalence in DM2 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      The cross-sectional study involved a total of 120 patients falling into three groups; Group I (healthy), Group II (periodontitis without DM2) and Group III (periodontitis with DM2) were subjected for sampling. Subgingival samples of periodontitis patients were tested for clinical parameters, and DNA extraction was performed. The presence of herpes virus (Epstein\u2013Barr virus [EBV-1] and human\n                      <jats:italic toggle=\"yes\">Cytomegalovirus<\/jats:italic>\n                      [HCMV]) was detected using multiplex polymerase chain reaction primers. Glycemic status of patients was recorded as glycosylated hemoglobin and scored accordingly. Chi-square test was performed to analyze the association between the categorical variables, and\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test\/Mann\u2013Whitney U-test\/analysis of variance\/Kruskal\u2013Wallis test was used for continuous data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Significant levels of EBV-1 were detected in Group III (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 21, 52.5%), followed by Group II (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 16, 40%) and Group I (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 2, 5%) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001). HCMV was not detected. A significant association of EBV-1 to periodontal site-specific parameters was observed in Group II patients (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). EBV-1 was predominant with poor glycemic status patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study revealed that the incidence of herpes virus infection in periodontal patients was higher in diabetic patients and the examined patients were prone to EBV-1 infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jomfp.jomfp_154_20","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T11:15:20Z","timestamp":1624878920000},"page":"141-146","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Prevalence of herpes virus in chronic periodontitis patients with and without type 2 diabetes 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