{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:31:47Z","timestamp":1787776307086,"version":"build-2784847793"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>Brown tumor is one of the lesions that develop in patients with hyperparathyroidism (HPT) and represents the terminal stages of bone remodeling process. Any of the skeletal bones can be affected including the craniomaxillofacial ones. Many a times, brown tumor was detected after a final diagnosis of HPT is made. However, on occasions, brown tumor can be the first clinical sign of the disease. Primary HPT is an uncommon systemic disease usually caused by hyperplasia or adenoma of the parathyroid glands. It causes overproduction of parathormone, which may affect the entire skeleton, causing bone resorption appear as cyst-like lesions called osteitis fibrosa cystica or brown tumors. Here, we report such a rare case in which multiple radiolucent lesions were noticed in the ramus part of the mandible and premolar region bilaterally, as the initial signs of primary HPT are presented in this report.<\/jats:p>","DOI":"10.4103\/jomfp.jomfp_166_19","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T05:33:16Z","timestamp":1578461596000},"page":"477-477","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":22,"title":["A complex case of brown tumors as initial manifestation of primary hyperparathyroidism in a young female"],"prefix":"10.4103","volume":"23","author":[{"given":"Bhari Sharanesha","family":"Manjunatha","sequence":"first","affiliation":[{"name":"Department of Oral Biology, Basic Oral Medicine and Allied Dental Sciences Division, College of Dentistry, Al-Hawaiya, AtTaif, Taif University, Taif, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharad","family":"Purohit","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Haldia Institute of Dental Sciences and Research, Halda, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Harsh","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Jhalawar Medical College and Hospital, Jhalawar, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagamahita","family":"Vangala","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Navodaya Dental College and Hospital, Raichur, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250525","first-page":"242","article-title":"Chronic renal failure causing brown tumors and myelopathy. Case report and review of pathophysiology and treatment","volume":"90","author":"Fineman","year":"1999","journal-title":"J Neurosurg"},{"key":"R3-20250525","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0196-0709(96)90075-7","article-title":"Brown tumor of the mandible","volume":"17","author":"Keyser","year":"1996","journal-title":"Am J Otolaryngol"},{"key":"R4-20250525","first-page":"26:61","article-title":"Brown tumor of maxilla \u2013 A rare occurrence","author":"Ashrafi","year":"2010","journal-title":"Pak J Otolaryngol"},{"key":"R5-20250525","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s10006-008-0105-9","article-title":"Bilateral maxillary brown tumours as the first presentation of primary hyperparathyroidism","volume":"12","author":"Jebasingh","year":"2008","journal-title":"Oral Maxillofac Surg"},{"key":"R6-20250525","first-page":"2010","article-title":"A rare complication of secondary hyperparathyroidism. Brown tumor of the maxilla and mandible","volume":"25","author":"Pinar Sumer","year":"2004","journal-title":"Saudi Med J"},{"key":"R7-20250525","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.tripleo.2004.01.015","article-title":"Primary hyperparathyroidism presenting as a palatal brown tumor","volume":"98","author":"Daniels","year":"2004","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R8-20250525","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3171\/jns.2003.98.2.0417","article-title":"Brown tumors of the skull base. Case report and review of the literature","volume":"98","author":"Al-Gahtany","year":"2003","journal-title":"J Neurosurg"},{"key":"R9-20250525","first-page":"415","article-title":"Maxillary brown tumor in secondary hyperparathyroidism requiring urgent parathyroidectomy","volume":"14","author":"Morrone","year":"2001","journal-title":"J Nephrol"},{"key":"R10-20250525","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1177\/014556130508400714","article-title":"Brown tumor of the facial bones: Case report and literature review","volume":"84","author":"Lessa","year":"2005","journal-title":"Ear Nose Throat J"},{"key":"R11-20250525","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1053\/joms.2003.50142","article-title":"Brown tumor of the maxilla and mandible: Progressive mandibular brown tumor after removal of parathyroid adenoma","volume":"61","author":"Yamazaki","year":"2003","journal-title":"J Oral Maxillofac Surg"},{"key":"R12-20250525","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ooe.2005.09.007","article-title":"Peripheral brown tumour of hyperparathyroidism in the oral cavity","volume":"42","author":"Guimaraes","year":"2006","journal-title":"Oral Oncol Extra"},{"key":"R13-20250525","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.amjoto.2005.11.004","article-title":"Brown tumors of the jaws associated with primary or secondary hyperparathyroidism. A clinical study and review of the literature","volume":"27","author":"Triantafillidou","year":"2006","journal-title":"Am J Otolaryngol"},{"key":"R15-20250525","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1053\/joms.2003.50073","article-title":"Expansile lesion of the mandible in a 45-year-old woman","volume":"61","author":"Shang","year":"2003","journal-title":"J Oral Maxillofac Surg"},{"key":"R16-20250525","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.joms.2004.02.011","article-title":"Brown tumor of the mandible as first manifestation of atypical parathyroid adenoma","volume":"62","author":"Suarez-Cunqueiro","year":"2004","journal-title":"J Oral Maxillofac Surg"},{"key":"R17-20250525","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1590\/S0004-27302006000500021","article-title":"Surgical approach and clinical outcome of a deforming brown tumor at the maxilla in a patient with secondary hyperparathyroidism due to chronic renal failure","volume":"50","author":"Leal","year":"2006","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"R18-20250525","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/S0278-2391(03)00734-1","article-title":"Expansile intraosseus lesion of the mandible","volume":"61","author":"Alvarado","year":"2003","journal-title":"J Oral Maxillofac Surg"},{"key":"R19-20250525","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1177\/000348949910800114","article-title":"Brown tumor of the palate in a patient with primary hyperparathyroidism","volume":"108","author":"Scott","year":"1999","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"R20-20250525","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s00402-007-0302-2","article-title":"Brown tumor with atypical localization in a normocalcemic patient","volume":"127","author":"Cebesoy","year":"2007","journal-title":"Arch Orthop Trauma Surg"},{"key":"R21-20250525","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.anl.2004.03.014","article-title":"Normocalcemic hyperparathyroidism presented with mandibular brown tumor: Report of a case","volume":"31","author":"Emin","year":"2004","journal-title":"Auris Nasus Larynx"}],"container-title":["Journal of Oral and Maxillofacial Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.JOMFP_166_19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:06:06Z","timestamp":1787774766000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.JOMFP_166_19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.4103\/jomfp.jomfp_166_19","relation":{},"ISSN":["0973-029X","1998-393X"],"issn-type":[{"value":"0973-029X","type":"print"},{"value":"1998-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"2019-05-23","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-03","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}