{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:45:32Z","timestamp":1787071532537,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>Brown Tumor is a rare, reactive, giant cell associated, late-stage bone lesion occuring as a result of long term untreated primary or secondary hyperparathyroidism (HPT). It clinically manifests as a high turnover bone disease, which typically shows increased parathyroid hormone (PTH) secretion in response to low serum calcium concentration thereby enhancing calcium reabsorption and osteoclastic bone resorption, hence called osteoclastoma or giant cell reparative granuloma or osteitis fibrosa cystica.<\/jats:p>\n                  <jats:p>Brown tumor associated with HPT can be seen in any part of the human skeleton, However clinically significant lesion involving the craniofacial skeleton is quite rare. Here we report a rare case of Brown tumor associated with HPT in a 28 year old female involving the right side of mandible.<\/jats:p>","DOI":"10.4103\/jomfp.jomfp_178_25","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T10:00:46Z","timestamp":1764324046000},"page":"S10-S14","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Brown tumor of mandible: A conundrum towards the diagnosis"],"prefix":"10.4103","volume":"29","author":[{"given":"Sayani","family":"Shome","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Haldia Institute of Dental Sciences and Research, Haldia, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manorama","family":"Dutta","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Haldia Institute of Dental Sciences and Research, Haldia, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aritra","family":"Laskar","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Haldia Institute of Dental Sciences and Research, Haldia, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudra P.","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences and Research, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"R1-20260420","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0196-0709(96)90075-7","article-title":"Brown tumour of the mandible","volume":"17","author":"Keyser","year":"1996","journal-title":"Am J Otolaryngol"},{"key":"R3-20260420","doi-asserted-by":"crossref","first-page":"108823","DOI":"10.1016\/j.ijscr.2023.108823","article-title":"Brown tumour of the jaw as a rare manifestation of hyperparathyroidism: Two case reports and literature review","volume":"111","author":"Hakkou","year":"2023","journal-title":"Int J Surg Case Rep"},{"key":"R4-20260420","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.12998\/wjcc.v12.i7.1200","article-title":"Expect the unexpected: Brown tumour of the mandible as the first manifestation of primary hyperparathyroidism","volume":"12","author":"Tengg","year":"2024","journal-title":"World J Clin Cases"},{"key":"R5-20260420","doi-asserted-by":"crossref","first-page":"33098","DOI":"10.1074\/jbc.M611781200","article-title":"Parathyroid hormone stimulates osteoblastic expression of MCP-1 to recruit and increase the fusion of pre\/osteoclasts","volume":"282","author":"Li","year":"2007","journal-title":"J Biol 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trends","volume":"2011","author":"Pradeep","year":"2011","journal-title":"Int J Endocrinol"},{"issue":"Suppl 1","key":"R11-20260420","doi-asserted-by":"crossref","first-page":"S209","DOI":"10.4103\/2230-8210.119574","article-title":"Primary hyperparathyroidism in India: A cocktail of contemporary and classical presentations: Lesson from 47 cases","volume":"17","author":"Maskey","year":"2013","journal-title":"Indian J Endocrinol Metab"},{"key":"R12-20260420","doi-asserted-by":"crossref","first-page":"477","DOI":"10.4103\/jomfp.JOMFP_166_19","article-title":"A complex case of brown tumours as initial manifestation of primary hyperparathyroidism in a young female","volume":"23","author":"Manjunatha","year":"2019","journal-title":"J Oral Maxillofac Pathol"},{"key":"R13-20260420","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1053\/joms.2003.50142","article-title":"Brown tumour of the maxilla and mandible: Progressive mandibular brown tumour after removal of parathyroid adenoma","volume":"61","author":"Yamazaki","year":"2003","journal-title":"J Oral Maxillofac Surg"},{"key":"R14-20260420","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ooe.2005.09.007","article-title":"Peripheral brown tumour of hyperparathyroidism in the oral cavity","volume":"42","author":"Guimar\u00e3es","year":"2006","journal-title":"Oral Oncology Extra"},{"key":"R15-20260420","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.amjoto.2005.11.004","article-title":"Brown tumours of the jaws associated with primary or secondary hyperparathyroidism. A clinical study and review of the literature","volume":"27","author":"Triantafillidou","year":"2006","journal-title":"Am J Otolaryngol"},{"key":"R17-20260420","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.bjoms.2007.04.014","article-title":"Mutations in SH3BP2, the cherubism gene, were not detected in central or peripheral giant cell tumours of the jaw","volume":"46","author":"Idowu","year":"2008","journal-title":"Br J Oral Maxillofac Surg"},{"key":"R18-20260420","first-page":"208","article-title":"Primary hyperparathyroidism. Presenting as brown tumours in the maxilla. 208","volume":"5","author":"Fernandez-Bustillo","year":"2000","journal-title":"Med Oral"}],"container-title":["Journal of Oral and Maxillofacial Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.jomfp_178_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:47:38Z","timestamp":1787068058000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.jomfp_178_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":15,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jomfp.jomfp_178_25","relation":{},"ISSN":["0973-029X","1998-393X"],"issn-type":[{"value":"0973-029X","type":"print"},{"value":"1998-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-06-18","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-18","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}