{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:51:34Z","timestamp":1791615094545,"version":"4.3.4"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,5]]},"abstract":"\n Background:<\/jats:title>\n Candidal infections have increased significantly in denture wearers, especially in immunocompromised patients. The increase in resistance to existing antifungal drugs and number of patients at risk, in conjunction with the restricted number of commercially available antifungal drugs that still present many side effects, are the cause for this problem. These limitations emphasize the need to develop new and more effective antifungal agents with lesser side effects.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n The present study was undertaken to investigate the possible antifungal action of the alcoholic extract of different concentrations of\n Curcuma longa<\/jats:italic>\n on four dilutions of\n Candida albicans<\/jats:italic>\n (1:10, 1:20, 1:40 and 1:80) and to determine its minimum inhibitory concentration (MIC) and minimum fungicidal concentration using Sabouraud's agar medium.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n There was complete inhibition of the growth of all four dilutions of\n Candida<\/jats:italic>\n at a concentration of 800 \u03bcl which is considered as the MIC of alcoholic extract of turmeric on\n C. albicans<\/jats:italic>\n , and the minimum fungicidal concentration was at 1600 \u03bcl.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n This study indicates a potent antifungal action of\n C. longa<\/jats:italic>\n against\n C. albicans<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jomfp.jomfp_200_18","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T08:27:16Z","timestamp":1566980836000},"page":"305-305","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":30,"title":["Evaluation of the antifungal efficacy of different concentrations of Curcuma longa on Candida albicans: An in vitro study"],"prefix":"10.4103","volume":"23","author":[{"given":"Jeevitha","family":"Murugesh","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Radiology, Government Dental College and Research Institute, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeshwari G","family":"Annigeri","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, College of Dental Sciences, Davangere, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G K","family":"Mangala","sequence":"additional","affiliation":[{"name":"Department of Microbiology, JJMMC, Davangere, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P Hema","family":"Mythily","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Government Dental College and Research Institute, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Chandrakala","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Government Dental College and Research Institute, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250922","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1348-0421.2003.tb03403.x","article-title":"A novel murine model of oral candidiasis with local symptoms characteristic of oral thrush","volume":"47","author":"Takakura","year":"2003","journal-title":"Microbiol Immunol"},{"key":"R2-20250922","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1128\/JCM.38.4.1563-1568.2000","article-title":"Emergence of resistance of Candida albicans to clotrimazole in human immunodeficiency virus-infected children: In vitro and clinical correlations","volume":"38","author":"Pelletier","year":"2000","journal-title":"J Clin Microbiol"},{"key":"R3-20250922","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.4103\/ccd.ccd_537_17","article-title":"Characterization of herbal antifungal agent, Origanum vulgare against oral Candida spp. Isolated from patients with Candida-associated denture stomatitis: An In vitro study","volume":"9","author":"Bhat","year":"2018","journal-title":"Contemp Clin Dent"},{"key":"R4-20250922","doi-asserted-by":"crossref","first-page":"185","DOI":"10.4236\/ojmm.2013.33028","article-title":"Effect of growth media, pH and temperature on yeast to Hyphal transition in Candida albicans","volume":"3","author":"Nadeem","year":"2013","journal-title":"Open J Med Microbiol"},{"key":"R5-20250922","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1590\/S0102-695X2011005000017","article-title":"Antifungal activity of the extract of Curcuma zedoaria (Christm.) Roscoe, Zingiberaceae, against yeasts of the genus Candida isolated from the oral cavity of patients infected with HIV","volume":"21","author":"Shinobu Mesquita","year":"2011","journal-title":"Braz J Pharmacogn"},{"key":"R6-20250922","first-page":"83","article-title":"Comparison of antibacterial activities of selected species of Zingiberaceae family and some synthetic compounds","volume":"29","author":"Chandarana","year":"2005","journal-title":"Turk J Biol"},{"key":"R7-20250922","first-page":"21","article-title":"Curcumin: From modern spice to anticancer drug","volume":"3","author":"Sa","year":"2010","journal-title":"Al Ameen J Med Sci"},{"key":"R8-20250922","first-page":"44","article-title":"Turmeric and curcumin: Biological actions and medicinal applications","volume":"87","author":"Chattopadhyay","year":"2004","journal-title":"Curr Sci"},{"key":"R9-20250922","doi-asserted-by":"crossref","first-page":"89369","DOI":"10.1155\/2007\/89369","article-title":"Mechanism of the anti-inflammatory effect of curcumin: PPAR-gamma activation","volume":"2007","author":"Jacob","year":"2007","journal-title":"PPAR Res"},{"key":"R10-20250922","doi-asserted-by":"crossref","first-page":"694","DOI":"10.6061\/clinics\/2013(05)18","article-title":"Effect of curcumin on human colon cancer multidrug resistance in vitro and in vivo","volume":"68","author":"Lu","year":"2013","journal-title":"Clinics (Sao Paulo)"},{"key":"R11-20250922","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.btre.2015.02.001","article-title":"Evaluation of antimicrobial activity of Curcuma longa rhizome extract against Staphylococcus aureus","volume":"6","author":"Gupta","year":"2015","journal-title":"Biotechnol Rep (Amst)"},{"key":"R12-20250922","first-page":"1172","article-title":"Evaluation of antimicrobial activity of volatile oil and total curcuminoids extracted from turmeric","volume":"3","author":"Singh","year":"2011","journal-title":"Int J Chem Tech Res"},{"key":"R13-20250922","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1469-0691.2003.00789.x","article-title":"Method for the determination of minimum inhibitory concentration (MIC) by broth dilution of fermentative yeasts","volume":"9","author":"Rodriguez-Tudela","year":"2003","journal-title":"Clin Microbiol Infect"},{"key":"R14-20250922","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4103\/0973-029X.44575","article-title":"Candida and calcofluor white: Study in precancer and cancer","volume":"13","author":"Kumar","year":"2009","journal-title":"J Oral Maxillofac Pathol"},{"key":"R15-20250922","first-page":"196","article-title":"Inhibitory effect of curcumin on Candida albicans compared with nystatin: An in vitro study","volume":"5","author":"Neda","year":"2016","journal-title":"J Dent Mater Tech"},{"key":"R16-20250922","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1128\/JCM.36.8.2383-2385.1998","article-title":"Colony size can be used to determine the MIC of fluconazole for pathogenic yeasts","volume":"36","author":"Xu","year":"1998","journal-title":"J Clin Microbiol"},{"key":"R17-20250922","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3109\/13693786.2011.578156","article-title":"Curcumin acts synergistically with fluconazole to sensitize a clinical isolate of Candida albicans showing a MDR phenotype","volume":"50","author":"Garcia-Gomes","year":"2012","journal-title":"Medical Mycology"},{"key":"R18-20250922","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/jac\/dkn488","article-title":"Curcumin as a promising antifungal of clinical interest","volume":"63","author":"Martins","year":"2009","journal-title":"J Antimicrob Chemother"},{"key":"R19-20250922","doi-asserted-by":"crossref","first-page":"659","DOI":"10.3389\/fmicb.2017.00659","article-title":"The anti-adhesive effect of curcumin on Candida albicans biofilms on denture materials","volume":"8","author":"Alalwan","year":"2017","journal-title":"Front Microbiol"},{"key":"R20-20250922","first-page":"570","article-title":"Synergistic anticandidal activity of pure polyphenol curcumin I in combination with azoles and polyenes generates reactive oxygen species leading to apoptosis","volume":"10","author":"Sharma","year":"2010","journal-title":"FEMS Yeast Res"},{"key":"R21-20250922","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1440-1681.2011.05648.x","article-title":"Discovery of curcumin, a component of golden spice, and its miraculous biological activities","volume":"39","author":"Gupta","year":"2012","journal-title":"Clin Exp Pharmacol Physiol"}],"container-title":["Journal of Oral and Maxillofacial Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01233803-201923020-00034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:45:48Z","timestamp":1787067948000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01233803-201923020-00034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.4103\/jomfp.jomfp_200_18","relation":{},"ISSN":["0973-029X","1998-393X"],"issn-type":[{"value":"0973-029X","type":"print"},{"value":"1998-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"2018-08-13","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-11","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}