{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:22:44Z","timestamp":1793226164469,"version":"4.5.0"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>\n                    Vitamin C, also known as ascorbic acid, is used as a treatment modality in depigmentation of hyperpigmented spots on the skin and gingiva. This systematic review discusses the studies conducted to assess the effect of Vitamin C on melanin pigmentation. The primary objective was to evaluate the effect of Vitamin C on melanin pigmentation. The secondary objective was to analyze the effect of Vitamin C administration on melanin pigmentation. An electronic database search was conducted from the following databases: PubMed, EBSCOhost, ScienceOpen, EMBASE and Google Scholar. Randomized controlled trials, experimental studies, case\u2013control studies and cohort studies published in peer-reviewed journals in English language were included. Case reports, case series, animal model studies,\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    studies, studies where Vitamin C was used along with other agents and unpublished research were excluded. Out of 22,580 studies, only 7 studies satisfied the selection criteria. Data extraction sheet was prepared, and the studies were analyzed. Out of the 7 studies analyzed, 1 was a randomized controlled trial and 6 were experimental studies. Vitamin C has been used widely as a depigmenting agent in dermatology. However, there are limited studies conducted on the use of Vitamin C for gingival depigmentation.\n                  <\/jats:p>","DOI":"10.4103\/jomfp.jomfp_207_20","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T17:16:06Z","timestamp":1600794966000},"page":"374-382","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":86,"title":["The effect of Vitamin C on melanin pigmentation \u2013 A systematic review"],"prefix":"10.4103","volume":"24","author":[{"given":"Rizwan M","family":"Sanadi","sequence":"first","affiliation":[{"name":"Department of Periodontics, Dr GD Pol Foundation's YMT Dental College, Kharghar, Sector - 4, Navi Mumbai and PhD Student, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Revati S","family":"Deshmukh","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Bharati Vidyapeeth Deemed to 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