{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:45:32Z","timestamp":1787071532182,"version":"build-2736575974"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>Myoepitheliomas are exceedingly rare neoplasms of the salivary glands. Minor salivary gland neoplasms most frequently occur in the palate (hard palate), followed by the lips, oral mucosa, and tongue\/floor of the mouth. Additionally, less prevalent locations encompass the retromolar area, pharynx, nasal cavity, paranasal sinuses, and larynx. The lack of distinctive cytologic features and bland morphology in both benign and malignant myoepitheliomas necessitates the use of histopathology and immunohistochemistry for accurate diagnosis. Hence, here, we report a series of three cases, including two benign and one malignant myoepithelioma, stressing the significance of the above-mentioned techniques for efficient diagnosis and management. This rare case series comprises many salivary gland myoepithelial neoplasms. Examples include the cystic plasmacytoid and clear cell myoepithelioma and low-grade myoepithelial carcinoma with parenchymal invasion. Immunohistochemical myoepithelial markers include vimentin, smooth muscle antigen, S 100, and p63. All of our patients had a positive p63. Myoepithelioma is diagnosed by biopsy because many tumours have similar clinical and radiological characteristics. They rarely reoccur, improving prognosis. Malignant myoepitheliomas may require wide local excision with clean margins. Regular follow-up is recommended. Myoepitheliomas are rare salivary gland tumours. Myoepithelioma should be suspected in slow-growing, well-defined salivary gland masses with variable post-contrast enhancement on CT images. Histopathology and immunohistochemistry are the best myoepithelioma diagnostic methods. Malignant myoepithelioma must be ruled out by thorough invasion testing.<\/jats:p>","DOI":"10.4103\/jomfp.jomfp_219_25","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T10:00:40Z","timestamp":1764324040000},"page":"S28-S33","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Decoding myoepithelioma: Highlighting diagnostic dilemmas through a series of rare cases"],"prefix":"10.4103","volume":"29","author":[{"given":"Mangesh","family":"Londhe","sequence":"first","affiliation":[{"name":"Department of Pathology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil Abhay","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushama","family":"Gurwale","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charusheela","family":"Gore","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"R1-20260420","doi-asserted-by":"crossref","first-page":"628","DOI":"10.4081\/cp.2014.628","article-title":"Clear cell myoepithelioma of palate with emphasis on clinical and histological differential diagnosis","volume":"4","author":"Nair","year":"2014","journal-title":"Clin Pract"},{"key":"R2-20260420","first-page":"6036179","article-title":"Myoepithelioma of the parotid gland: A case report with review of the literature and classic histopathology","volume":"2017","author":"Weitzel","year":"2017","journal-title":"Case Rep Otolaryngol"},{"key":"R3-20260420","first-page":"642806","article-title":"Myoepithelioma of the soft palate: A case report","volume":"2013","author":"Yadav","year":"2013","journal-title":"Case Rep Otolaryngol"},{"key":"R4-20260420","doi-asserted-by":"crossref","first-page":"4924","DOI":"10.5144\/0256-4947.2013.492","article-title":"Clear cell myoepithelioma of the hard palate","volume":"33","author":"Hakeem","year":"2013","journal-title":"Ann Saudi Med"},{"key":"R5-20260420","doi-asserted-by":"crossref","first-page":"e240384","DOI":"10.1136\/bcr-2020-240384","article-title":"Benign myoepithelioma of the soft palate: An unusual clinical entity","volume":"14","author":"Mireles","year":"2021","journal-title":"BMJ Case Rep"},{"key":"R6-20260420","first-page":"e12321","article-title":"Myoepithelial carcinoma of the floor of the mouth: A rare salivary gland tumour in an unusual location","volume":"12","author":"Ali","year":"2020","journal-title":"Cureus"},{"key":"R8-20260420","first-page":"E552","article-title":"Plasmacytoid myoepithelioma of the palate. Report of one case and review of the literature","volume":"12","author":"Cuadra Zelaya","year":"2007","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"R9-20260420","first-page":"667","article-title":"Subcutaneous myoepithelioma in the extremity: A potential pitfall in the differential diagnosis of subcutaneous tumors","volume":"59","author":"Koo","year":"2023","journal-title":"Curr Med Chem"},{"key":"R10-20260420","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3348\/jksr.2011.65.1.23","article-title":"Computed tomography and magnetic resonance imaging of myoepitheliloma in the soft palate: A case report","volume":"65","author":"Lim","year":"2011","journal-title":"J Korean Soc Radiol"},{"key":"R11-20260420","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1159\/000326377","article-title":"Myoepithelioma of the salivary glands. Fineneedle aspiration biopsy findings","volume":"48","author":"Kumar","year":"2004","journal-title":"Acta Cytol"},{"key":"R12-20260420","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.4103\/0973-029X.131942","article-title":"Fineneedle aspiration findings in epithelioid myoepithelioma of the parotid gland: A diagnostic pitfall","volume":"18","author":"Gayathri","year":"2014","journal-title":"J Oral Maxillofac Pathol"},{"key":"R13-20260420","doi-asserted-by":"crossref","first-page":"117955491983825","DOI":"10.1177\/1179554919838254","article-title":"Myoepithelial cell carcinoma of the oral tongue: Case report and review of the literature","volume":"13","author":"Nicholas","year":"2019","journal-title":"Clin Med Insights Oncol"}],"container-title":["Journal of Oral and Maxillofacial Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.jomfp_219_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:47:39Z","timestamp":1787068059000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.jomfp_219_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":12,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jomfp.jomfp_219_25","relation":{},"ISSN":["0973-029X","1998-393X"],"issn-type":[{"value":"0973-029X","type":"print"},{"value":"1998-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-07-23","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-30","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}