{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:21:45Z","timestamp":1787772105446,"version":"build-2784847793"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In recent years,\n                    <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                    has emerged as a significant opportunistic pathogen, causing various infections, particularly in immunocompromised geriatric individuals. One of the major hindrances in managing\n                    <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                    infections lies in its potential to develop and survive in biofilms, which demonstrate resistance to conventional antifungal therapies, thereby complicating treatment strategies. While clove oil has shown promising results as a potential antifungal agent, its specific anti-biofilm effects against\n                    <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                    biofilms remain relatively underexplored. Therefore, there is a need for a comprehensive review to evaluate the existing literature on the anti-biofilm properties of clove oil and its mechanisms of action against\n                    <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                    biofilms. Such a review will provide valuable insights into the potential therapeutic applications of clove oil in combating biofilm-associated\n                    <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                    infections. This review will enable us to infer and understand the potential effects of clove oil against\n                    <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                    . This systematic review aims to determine the anti-biofilm efficacy of clove oil against\n                    <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                    . This systematic review was registered in \u2018PROSPERO\u2019 (CRD42024524134) and followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The literature searches used Google Scholar, PubMed, and Science Direct databases. All original studies published in English from 2004 to 2023 were included. From 37 studies found online, only four were reviewed. Results showed that clove oil had significant anti-biofilm activity when assessed against\n                    <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                    . Our systematic review provides insights into clove oil\u2019s potential as a therapeutic agent against\n                    <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                    biofilms. Clove oil also represents a promising avenue for future research and development in managing\n                    <jats:italic toggle=\"yes\">Candida biofilms<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.4103\/jomfp.jomfp_225_24","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T08:01:01Z","timestamp":1735632061000},"page":"665-671","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Anti-biofilm effect of clove oil against Candida albicans: A systematic review"],"prefix":"10.4103","volume":"28","author":[{"given":"J Palaskar","family":"Sangeeta","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Sinhgad Dental College and Hospital, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O Balsaraf","family":"Aishwarya","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Sinhgad Dental College and Hospital, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D Balsaraf","family":"Omkar","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Sinhgad Dental College and Hospital, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N Bhave","family":"Madhura","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Sinhgad Dental College and Hospital, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,12,31]]},"reference":[{"key":"R1-20250108","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41579-018-0089-x","article-title":"The oral microbiota: Dynamic communities and host interactions","volume":"16","author":"Lamont","year":"2018","journal-title":"Nat Rev Microbiol"},{"key":"R2-20250108","doi-asserted-by":"crossref","first-page":"122","DOI":"10.4103\/jomfp.JOMFP_304_18","article-title":"Oral microbiome: Unveiling the fundamentals","volume":"23","author":"Deo","year":"2019","journal-title":"J Oral Maxillofac Pathol"},{"key":"R3-20250108","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3390\/jof6010015","article-title":"Oral candidiasis: A disease of opportunity","volume":"6","author":"Vila","year":"2020","journal-title":"J Fungi"},{"key":"R4-20250108","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3390\/pathogens11030335","article-title":"Oral cavity and candida albicans: Colonisation to the development of infection","volume":"11","author":"Patel","year":"2022","journal-title":"Pathogens"},{"key":"R5-20250108","first-page":"e43697","article-title":"Advances in the management of diabetes mellitus: A focus on personalized medicine","volume":"15","author":"Sugandh","year":"2023","journal-title":"Cureus"},{"key":"R6-20250108","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1021\/acs.chemrev.0c00199","article-title":"Antifungal drug resistance: Molecular mechanisms in candida albicans and beyond","volume":"121","author":"Lee","year":"2021","journal-title":"Chem Rev"},{"key":"R7-20250108","doi-asserted-by":"crossref","first-page":"1192955","DOI":"10.3389\/fmicb.2023.1192955","article-title":"Antimicrobial photodynamic therapy against oral biofilm: Influencing factors, mechanisms, and combined actions with other strategies","volume":"14","author":"Li","year":"2023","journal-title":"Front Microbiol"},{"key":"R8-20250108","doi-asserted-by":"crossref","first-page":"115389","DOI":"10.1016\/j.ecoenv.2023.115389","article-title":"Bacterial biofilm inhibitors: An overview","volume":"264","author":"Kalia","year":"2023","journal-title":"Ecotoxicol Environ Saf"},{"key":"R9-20250108","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.tim.2020.03.016","article-title":"Biofilm matrixome: Extracellular components in structured microbial communities","volume":"28","author":"Karygianni","year":"2020","journal-title":"Trends Microbiol"},{"key":"R10-20250108","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3390\/jof7020079","article-title":"Candida albicans- The virulence factors and clinical manifestations of infection","volume":"7","author":"Talapko","year":"2021","journal-title":"J Fungi (Basel)"},{"key":"R11-20250108","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.3390\/microorganisms10101989","article-title":"Cinnamon leaf and clove essential oils are potent inhibitors of candida albicans virulence traits","volume":"10","author":"Shahina","year":"2022","journal-title":"Microorganisms"},{"key":"R12-20250108","doi-asserted-by":"crossref","first-page":"28","DOI":"10.15698\/mic2021.02.741","article-title":"Biofilms by bacterial human pathogens: Clinical relevance - 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