{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:38:59Z","timestamp":1788320339553,"version":"build-2803163510"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Amyloidosis is a distressing and infrequent condition caused by accumulation of abnormally folded proteins as aggregates in the extracellular tissue spaces of the body, leading to destruction of organ structure and function. Presentation of Oral Amyloidosis is generally a rare phenomenon, tongue being the most common site to manifest the disease process. Accurate recognition of the amyloid protein and its sub typing is absolutely critical for clinical management and to assess prognosis such as to avoid misdiagnosis and unwanted, potentially harmful treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report:<\/jats:title>\n                    <jats:p>We report a case of 84 year old male patient with an enlarged tongue, who presented with burning sensation and a facial violaceous papules with no other known systemic findings. Incisional biopsy revealed amorphous deposits confirmed for amyloid by congo red stain and Immunohistochemistry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The suspicion of Amyloidosis should always be kept in mind whenever a solitary enlargement of the tongue is noticed. Close follow-up and an entire panel of investigations is mandatory, both to manage recurrences and to monitor the possible advancement of the disease into a full blown systemic form.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jomfp.jomfp_227_20","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T04:51:07Z","timestamp":1642567867000},"page":"559","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Oral amyloidosis"],"prefix":"10.4103","volume":"25","author":[{"given":"Sudip","family":"Indu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indranil Deb","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Tewari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suman","family":"Pramanik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-52-20240906","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/imj.12288","article-title":"How to diagnose amyloidosis","volume":"44","author":"Mollee","year":"2014","journal-title":"Int Med J"},{"key":"R2-52-20240906","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1136\/bmj.309.6966.1386","article-title":"Macroglossia","volume":"309","author":"Murthy","year":"1994","journal-title":"BMJ"},{"key":"R3-52-20240906","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1001\/archinte.166.17.1805","article-title":"Amyloidosis and the heart: Acomprehensive review","volume":"166","author":"Shah","year":"2006","journal-title":"Arch Intern Med"},{"key":"R4-52-20240906","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1001\/jama.1952.72930190001009","article-title":"Macroglossia as a manifestation of primary systemic amyloidosis; report of a case","volume":"149","author":"Ensign","year":"1952","journal-title":"J Am Med Assoc"},{"key":"R5-52-20240906","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.2215\/CJN.02740806","article-title":"Light-chain (AL) amyloidosis: Diagnosis and treatment","volume":"1","author":"Sanchorawala","year":"2006","journal-title":"Clin J Am Soc Nephrol"},{"key":"R6-52-20240906","first-page":"2976","article-title":"Oral infections, a mirror of our overall health condition: An overview","volume":"4","author":"Singh","year":"2013","journal-title":"Int J Pharm Life Sci"},{"key":"R7-52-20240906","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/nrneph.2013.171","article-title":"Pathophysiology and treatment of systemic amyloidosis","volume":"9","author":"Gillmore","year":"2013","journal-title":"Nat Rev Nephrol"},{"key":"R8-52-20240906","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s10006-009-0158-4","article-title":"Local amyloidosis in the hard palate: A case report","volume":"13","author":"Aono","year":"2009","journal-title":"Oral Maxillofac Surg"},{"key":"R9-52-20240906","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.tripleo.2010.10.028","article-title":"The presence of amyloid in abdominal and oral mucosal tissues in patients initially diagnosed with multiple myeloma: A pilot study","volume":"111","author":"Stoopler","year":"2011","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R10-52-20240906","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3324\/haematol.2013.087619","article-title":"Update on treatment of light chain amyloidosis","volume":"99","author":"Mahmood","year":"2014","journal-title":"Haematologica"},{"key":"R11-52-20240906","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1309\/LYWM47K2L8XYFFB3","article-title":"Quantitative analysis of serum free light chains. A new marker for the diagnostic evaluation of primary systemic amyloidosis","volume":"119","author":"Abraham","year":"2003","journal-title":"Am J Clin Pathol"},{"key":"R12-52-20240906","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/clinchem\/48.9.1437","article-title":"Serum reference intervals and diagnostic ranges for free \u03ba and free \u03bb immunoglobulin light chains: Relative sensitivity for detection of monoclonal light chains","volume":"48","author":"Katzmann","year":"2002","journal-title":"Clini Chem"},{"key":"R13-52-20240906","doi-asserted-by":"crossref","first-page":"6723575","DOI":"10.1155\/2016\/6723575","article-title":"A Tongue Lesion as a sign of a systemic disease","volume":"2016","author":"Liakou","year":"2016","journal-title":"Case Rep Med"},{"key":"R14-52-20240906","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3109\/13506120903421538","article-title":"Serum levels of NT-proBNP as surrogate for cardiac amyloid burden: New evidence from gadolinium-enhanced cardiac magnetic resonance imaging in patients with amyloidosis","volume":"16","author":"Lehrke","year":"2009","journal-title":"Amyloid"},{"key":"R15-52-20240906","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41408-018-0080-9","article-title":"Immunoglobulin light chain amyloidosis diagnosis and treatment algorithm 2018","volume":"8","author":"Gertz","year":"2018","journal-title":"Blood Cancer J"},{"key":"R16-52-20240906","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.jchf.2017.04.006","article-title":"Cardiac amyloidosis as a potential confounder in heart failure with preserved ejection fraction trials","volume":"5","author":"Schelbert","year":"2017","journal-title":"JACC Heart Fail"},{"key":"R17-52-20240906","first-page":"1307","article-title":"Paraproteinemic neuropathies. Continuum (Minneap","volume":"20","author":"Mauermann","year":"2014","journal-title":"Minn"},{"key":"R18-52-20240906","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0901-5027(99)80204-5","article-title":"Surgical management of macroglossia due to primary amyloidosis","volume":"28","author":"Mardinger","year":"1999","journal-title":"Int J Oral Maxillofac Surg"},{"key":"R19-52-20240906","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1007\/s00784-015-1649-3","article-title":"Involvement of oral tissues by AL amyloidosis: A literature review and report of eight new cases","volume":"20","author":"Matsuo","year":"2016","journal-title":"Clin Oral Investig"},{"key":"R20-52-20240906","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1182\/blood-2009-07-230722","article-title":"Classification of amyloidosis by laser microdissection and mass spectrometry\u2013based proteomic analysis in clinical biopsy specimen","volume":"114","author":"Vrana","year":"2009","journal-title":"Blood"},{"key":"R21-52-20240906","doi-asserted-by":"crossref","first-page":"16291","DOI":"10.1073\/pnas.1315112110","article-title":"Amyloid and inflammation","volume":"110","author":"Gorevic","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R22-52-20240906","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1080\/13506120500537343","article-title":"Localized oral amyloidosis of the palate","volume":"13","author":"Pentenero","year":"2006","journal-title":"Amyloid"}],"container-title":["Journal of Oral and Maxillofacial Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.JOMFP_227_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:07:12Z","timestamp":1787166432000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.JOMFP_227_20"}},"subtitle":["A case report and diagnostic algorithm"],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/jomfp.jomfp_227_20","relation":{},"ISSN":["0973-029X"],"issn-type":[{"value":"0973-029X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]}}}