{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T14:24:39Z","timestamp":1783347879737,"version":"3.54.6"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess immunohistochemically the presence of c-Myc both qualitatively and quantitatively in odontogenic cysts and tumours and to correlate the results with biological behaviour of these lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Formalin-fixed, paraffin-embedded blocks of odontogenic cysts and tumours were retrieved from institutional archives. The study sample size was 45 (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 45), which included 10 cases of odontogenic keratocyst cyst (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 10), five cases of radicular cyst (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 5), five cases of dentigerous cyst (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 5), and 10 cases of solid ameloblastoma of which five cases are follicular (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 5) and five cases are plexiform (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 5), 10 cases of Adenomatoid odontogenic tumour (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 10) and five cases of unicystic ameloblastoma (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 5). Sections were taken and stained immunohistochemically using c-Myc and evaluated both for quantitative and qualitative analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In the current study, the mean number of c-Myc positive cells in the odontogenic tumours was highest in solid Ameloblastoma (78.6 \u00b1 11.59), followed by Adenomatoid odontogenic tumor (AOT) (75.30 \u00b1 39.853) and least in unicystic ameloblastoma (56.6 \u00b1 20.53). Among odontogenic cysts, the mean number of c-Myc positive cells was higher in Odontogenic keratocyst (OKC) (73.2 \u00b1 17.937) compared to dentigerous cyst (28.0 \u00b1 27.9) and radicular cysts (31.0 \u00b1 31.7). The staining intensity varied in odontogenic cysts and tumours<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The results and observations of the present study show that c-Myc plays a role in the aggressive biological behaviour of odontogenic lesions like ameloblastoma and OKC. So, it can be used as a proliferative marker. However, additional immunohistochemical and DNA assays are to be carried to determine the role of c-Myc oncogene and to know if any mutations may play a role in the pathogenesis of these odontogenic lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jomfp.jomfp_232_25","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T18:00:28Z","timestamp":1783101628000},"page":"209-216","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of c-Myc in odontogenic cysts and tumours\u2014An immunohistochemical study"],"prefix":"10.4103","volume":"30","author":[{"given":"Soujanya","family":"Pinisetti","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Government Dental College and Hospital, Kadapa, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nallagangula L.","family":"Vinaya","sequence":"additional","affiliation":[{"name":"Oral Pathologist, Private Practitioner, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveena","family":"Adusumilli","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, MNR Dental College and Hospital, Sangareddy, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Babburi","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Drs Sudha and Nageswara Rao Siddhartha Institute of Dental Sciences, Gannavaram Mandal, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Venigalla","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Drs Sudha and Nageswara Rao Siddhartha Institute of Dental Sciences, Gannavaram Mandal, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Benarjee","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Drs Sudha and Nageswara Rao Siddhartha Institute of Dental Sciences, Gannavaram Mandal, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"R1-20260706","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S1368-8375(01)00066-5","article-title":"The aggressive nature of the odontogenic keratocyst: Is it a benign cystic neoplasm? 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