{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:42:25Z","timestamp":1786653745014,"version":"build-2736575974"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study, a collaborative effort that delves into the interlinkage of salivary biomarkers in rheumatoid arthritis (RA), combines literature review with STRING and Cytoscape data. The discovery of elevated matrix metalloproteinases (MMPs) and pro-inflammatory cytokines, such as TNF-\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    , IL-6, and IL-17 in saliva, and their link to joint and oral tissue damage in RA, is a significant finding. These biomarkers are crucial in understanding RA\u2019s inflammatory and destructive processes and oral manifestations. The analysis revealed significant interactions among biomarkers, with IL1B demonstrating strong coexpression with MMP1 and TIMP1, while MMP1 and TIMP1 showed a robust relationship. Cytoscape data further highlighted vital interactions, such as the solid functional relationship between IL2RB and IL2RG and the central role of MMP1 in matrix remodelling. The integration of these data, a result of our collective efforts, provides profound insights into the pathogenesis of RA and its impact on oral health, supporting the development of targeted diagnostic and therapeutic approaches.\n                  <\/jats:p>","DOI":"10.4103\/jomfp.jomfp_23_24","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T12:31:49Z","timestamp":1743337909000},"page":"117-126","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Salivary biomarker profile in rheumatoid arthritis and its interlinkage in oral manifestations: A comprehensive review"],"prefix":"10.4103","volume":"29","author":[{"given":"Anitha K.","family":"Pandarathodiyil","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, SEGi University, Kota Damansara, Petaling Jaya, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K Hema","family":"Shree","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Saveetha Dental College and Hospitals, Saveetha Institute Medical and Technical Science, Saveetha University, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Sivapathasundharam","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Priyadarshini Dental College, Thiruvallur, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramya","family":"Ramadoss","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Saveetha Dental College and Hospitals, Saveetha Institute Medical and Technical Science, Saveetha University, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"R1-20250328","doi-asserted-by":"crossref","first-page":"7019","DOI":"10.1007\/s00784-023-05305-7","article-title":"Association between rheumatoid arthritis and pulpal-periapical pathology: A systematic review","volume":"27","author":"Karata\u015f","year":"2023","journal-title":"Clin Oral Investig"},{"key":"R2-20250328","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3390\/jcm8010021","article-title":"Main oral manifestations in immune-mediated and inflammatory rheumatic diseases","volume":"8","author":"Gualtierotti","year":"2018","journal-title":"J Clin Med"},{"key":"R3-20250328","first-page":"15","article-title":"[Pathophysiology of rheumatoid arthritis","volume":"50","author":"Morovi\u0107-Vergles","year":"2003","journal-title":"Reumatizam"},{"issue":"7 Suppl","key":"R4-20250328","first-page":"S128","article-title":"Epidemiology, pathophysiology, and diagnosis of rheumatoid arthritis: A Synopsis","volume":"20","author":"Gibofsky","year":"2014","journal-title":"Am J Manag Care"},{"key":"R5-20250328","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/ar3106","article-title":"The association between rheumatoid arthritis and periodontal disease","volume":"12","author":"Detert","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"R6-20250328","doi-asserted-by":"crossref","first-page":"259074","DOI":"10.1155\/2015\/259074","article-title":"Relationship between periodontitis and rheumatoid arthritis: Review of the literature","author":"Ara\u00fajo","year":"2015","journal-title":"Mediators Inflamm 2015"},{"key":"R7-20250328","doi-asserted-by":"crossref","first-page":"e980","DOI":"10.4317\/jced.57562","article-title":"Association between rheumatoid arthritis and periodontitis in an adult population-A cross sectional study","volume":"13","author":"Varshney","year":"2021","journal-title":"J Clin Exp Dent"},{"key":"R8-20250328","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/BF00918681","article-title":"Rheumatoid factor (RF) distribution in periodontal disease","volume":"11","author":"Th\u00e9","year":"1991","journal-title":"J Clin Immunol"},{"key":"R9-20250328","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1128\/IAI.67.7.3248-3256.1999","article-title":"Purification, characterization, and sequence analysis of a potential virulence factor from Porphyromonas gingivalis, peptidylarginine deiminase","volume":"67","author":"McGraw","year":"1999","journal-title":"Infect Immun"},{"key":"R10-20250328","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1111\/j.1600-051X.2010.01625.x","article-title":"Rheumatoid arthritis and salivary biomarkers of periodontal disease","volume":"37","author":"Mirrielees","year":"2010","journal-title":"J Clin Periodontol"},{"key":"R11-20250328","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/07853890.2018.1468922","article-title":"Inflammatory biomarkers in saliva and serum of patients with rheumatoid arthritis with respect to periodontal status","volume":"50","author":"\u00c4yr\u00e4v\u00e4inen","year":"2018","journal-title":"Ann Med"},{"key":"R12-20250328","doi-asserted-by":"crossref","first-page":"841139","DOI":"10.3389\/fcimb.2022.841139","article-title":"Salivary microbiota and host-inflammatory responses in periodontitis affected individuals with and without rheumatoid arthritis","volume":"12","author":"Eriksson","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"R13-20250328","doi-asserted-by":"crossref","first-page":"13525","DOI":"10.1038\/s41598-021-93008-y","article-title":"Salivary citrullinated proteins in rheumatoid arthritis and associated periodontal disease","volume":"11","author":"Tar","year":"2021","journal-title":"Sci Rep"},{"key":"R14-20250328","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.autrev.2014.08.012","article-title":"Anti-citrullinated peptides as autoantigens in rheumatoid arthritis-relevance to treatment","volume":"13","author":"Sakkas","year":"2014","journal-title":"Autoimmun Rev"},{"key":"R15-20250328","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ijwd.2020.07.011","article-title":"The possible role of oral microbiome in autoimmunity","volume":"6","author":"Zorba","year":"2020","journal-title":"Int J Womens Dermatol"},{"key":"R16-20250328","doi-asserted-by":"crossref","first-page":"17038","DOI":"10.1038\/nrdp.2017.38","article-title":"Periodontal diseases","volume":"3","author":"Kinane","year":"2017","journal-title":"Nat Rev Dis Primer"},{"key":"R17-20250328","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fimmu.2016.00080","article-title":"Hand to mouth: A systematic review and meta-analysis of the association between rheumatoid arthritis and periodontitis","volume":"7","author":"Fuggle","year":"2016","journal-title":"Front Immunol"},{"key":"R18-20250328","doi-asserted-by":"crossref","first-page":"369ra176","DOI":"10.1126\/scitranslmed.aaj1921","article-title":"Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis","volume":"8","author":"Konig","year":"2016","journal-title":"Sci Transl Med"},{"key":"R19-20250328","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1600-051X.1998.tb02419.x","article-title":"Microbial complexes in subgingival plaque","volume":"25","author":"Socransky","year":"1998","journal-title":"J Clin Periodontol"},{"key":"R20-20250328","doi-asserted-by":"crossref","first-page":"8379","DOI":"10.1038\/s41598-019-44674-6","article-title":"Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients","volume":"9","author":"Corr\u00eaa","year":"2019","journal-title":"Sci Rep"},{"key":"R21-20250328","first-page":"0","article-title":"Oral-Gut Microbiota and Arthritis: Is There an Evidence-Based Axis?","volume":"8","author":"Lorenzo","year":"2019","journal-title":"J Clin Med"},{"key":"R22-20250328","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1056\/NEJMra1004965","article-title":"The pathogenesis of rheumatoid arthritis","volume":"365","author":"McInnes","year":"2011","journal-title":"N Engl J Med"},{"key":"R23-20250328","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41413-018-0016-9","article-title":"Rheumatoid arthritis: Pathological mechanisms and modern pharmacologic therapies","volume":"6","author":"Guo","year":"2018","journal-title":"Bone Res"},{"key":"R24-20250328","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11926-020-00960-1","article-title":"Microbial influences of mucosal immunity in rheumatoid arthritis","volume":"22","author":"Wilson","year":"2020","journal-title":"Curr Rheumatol Rep"},{"key":"R25-20250328","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nrrheum.2009.28","article-title":"Periodontitis in systemic rheumatic diseases","volume":"5","author":"de Pablo","year":"2009","journal-title":"Nat Rev Rheumatol"},{"key":"R26-20250328","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1002\/art.38348","article-title":"Periodontitis and porphyromonas gingivalis in patients with rheumatoid arthritis","volume":"66","author":"Mikuls","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"R27-20250328","doi-asserted-by":"crossref","first-page":"236","DOI":"10.5114\/reum.2020.98436","article-title":"The relationship between periodontal status and rheumatoid arthritis \u2013Systematic review","volume":"58","author":"Samborska-Mazur","year":"2020","journal-title":"Reumatologia"},{"key":"R28-20250328","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s12967-018-1588-2","article-title":"Increased citrullination and expression of peptidylarginine deiminases independently of P. gingivalis and A. actinomycetemcomitans in gingival tissue of patients with periodontitis","volume":"16","author":"Engstr\u00f6m","year":"2018","journal-title":"J Transl Med"},{"key":"R29-20250328","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1002\/art.27552","article-title":"Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and \u03b1-enolase: implications for autoimmunity in rheumatoid arthritis","volume":"62","author":"Wegner","year":"2010","journal-title":"Arthritis Rheum"},{"key":"R30-20250328","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1002\/art.22983","article-title":"Peptidyl arginine deiminase type 2 (PAD-2) and PAD-4 but not PAD-1, PAD-3, and PAD-6 are expressed in rheumatoid arthritis synovium in close association with tissue inflammation","volume":"56","author":"Foulquier","year":"2007","journal-title":"Arthritis Rheum"},{"key":"R31-20250328","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1002\/art.39783","article-title":"Dysbiosis contributes to arthritis development via activation of autoreactive T cells in the intestine","volume":"68","author":"Maeda","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"R32-20250328","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1002\/art.40003","article-title":"Evidence of the immune relevance of prevotella copri, a gut microbe, in patients with rheumatoid arthritis","volume":"69","author":"Pianta","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"R33-20250328","doi-asserted-by":"crossref","first-page":"e01202","DOI":"10.7554\/eLife.01202","article-title":"Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis","volume":"2","author":"Scher","year":"2013","journal-title":"Elife"},{"key":"R34-20250328","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/nm.3914","article-title":"The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment","volume":"21","author":"Zhang","year":"2015","journal-title":"Nat Med"},{"key":"R35-20250328","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13073-016-0299-7","article-title":"An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis","volume":"8","author":"Chen","year":"2016","journal-title":"Genome Med"},{"key":"R36-20250328","doi-asserted-by":"crossref","first-page":"e0186346","DOI":"10.1371\/journal.pone.0186346","article-title":"Factors associated with the risk of gingival disease in patients with rheumatoid arthritis","volume":"12","author":"Huang","year":"2017","journal-title":"PLoS One"},{"key":"R38-20250328","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/art.1780360609","article-title":"Low-dose methotrexate with leucovorin (folinic acid) in the management of rheumatoid arthritis. Results of a multicenter randomized, double-blind, placebo-controlled trial","volume":"36","author":"Shiroky","year":"1993","journal-title":"Arthritis Rheum"},{"key":"R39-20250328","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1136\/ard.2008.092668","article-title":"Optimal dosage and route of administration of methotrexate in rheumatoid arthritis: A systematic review of the literature","volume":"68","author":"Visser","year":"2009","journal-title":"Ann Rheum Dis"}],"container-title":["Journal of Oral and Maxillofacial Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.jomfp_23_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:41:48Z","timestamp":1786650108000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.jomfp_23_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jomfp.jomfp_23_24","relation":{},"ISSN":["0973-029X","1998-393X"],"issn-type":[{"value":"0973-029X","type":"print"},{"value":"1998-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-01-23","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-24","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}