{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:35:48Z","timestamp":1787841348147,"version":"build-2784847793"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To evaluate the clinical and microbiological effects of local drug delivery of moxifloxacin and ibuprofen gel as an adjunct to conventional periodontal therapy in chronic periodontitis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods:<\/jats:title>\n                    <jats:p>Twenty patients with moderate-to-severe chronic generalized periodontitis with probing pocket depth (PPD) of \u22655 mm and &lt;8 mm were randomly assigned to one of the following two treatment modalities: scaling and root planing (SRP) group and moxifloxacin and ibuprofen combination gel as an adjunct to SRP group. Clinical parameters include plaque index (PI), gingival index (GI), probing depths and clinical attachment level (CAL) that were recorded at baseline and 1 and 3 months after the treatment, and microbiologic assessment was done using dark-field microscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A statistically significant difference in mean PI and GI scores and reduction in PPD and gain in CAL were observed at different study intervals with greater difference in the test group. On microbiological examination, the percentage of cocci increased, while a statistically significant decrease in the mean percentage of bacilli and spirochetes was observed in both groups at given intervals. In-vitro dissolution showed controlled release of both the drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Among the two treatment modalities, treatment with moxifloxacin and ibuprofen local delivery as an adjunct to SRP gave superior results in clinical and microbiological parameters compared to SRP group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jomfp.jomfp_253_19","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T15:47:24Z","timestamp":1588866444000},"page":"26-32","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Clinicomicrobiological evaluation of the efficacy of local delivery of moxifloxacin and ibuprofen gel as an adjunct to scaling and root planing in chronic periodontitis patients"],"prefix":"10.4103","volume":"24","author":[{"given":"Ramyasri","family":"Kadadasu","sequence":"first","affiliation":[{"name":"Department of Periodontics, Kamineni Institute of Dental Sciences, Nalgonda, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhinav","family":"Atchuta","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Kamineni Institute of Dental Sciences, Nalgonda, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajababu","family":"Palaparthy","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Kamineni Institute of Dental Sciences, Nalgonda, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S Harinath","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Kamineni Institute of Dental Sciences, Nalgonda, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidyasagar","family":"Sisinty","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Kamineni Institute of Dental Sciences, Nalgonda, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounika","family":"Beeravolu","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Kamineni Institute of Dental Sciences, Nalgonda, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,5,8]]},"reference":[{"key":"R1-20250920","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1600-051X.1984.tb01323.x","article-title":"Recolonization of a subgingival microbiota following scaling in deep pockets","volume":"11","author":"Magnusson","year":"1984","journal-title":"J Clin Periodontol"},{"key":"R2-20250920","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1600-051X.1979.tb01935.x","article-title":"Subgingival microflora and periodontal disease","volume":"6","author":"Slots","year":"1979","journal-title":"J Clin Periodontol"},{"issue":"Suppl 2","key":"R3-20250920","first-page":"17","article-title":"Systemic medications: Clinical significance in periodontics","volume":"29","author":"Ciancio","year":"2002","journal-title":"J Clin Periodontol"},{"key":"R4-20250920","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1600-051X.1979.tb02186.x","article-title":"Periodontal therapy by local delivery of tetracycline","volume":"6","author":"Goodson","year":"1979","journal-title":"J Clin Periodontol"},{"key":"R5-20250920","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1902\/jop.1993.64.8s.782","article-title":"Controlled-release local delivery antimicrobials in periodontics: Prospects for the future","volume":"64","author":"Kornman","year":"1993","journal-title":"J Periodontol"},{"key":"R6-20250920","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10096-008-0587-2","article-title":"Clinical and microbiological efficacy of moxifloxacin versus amoxicillin\/clavulanic acid in severe odontogenic abscesses: A pilot study","volume":"28","author":"Al-Nawas","year":"2009","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"R7-20250920","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1902\/jop.2010.100124","article-title":"Efficacy and safety of adjunctive local moxifloxacin delivery in the treatment of periodontitis","volume":"82","author":"Flemmig","year":"2011","journal-title":"J Periodontol"},{"key":"R8-20250920","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1600-0765.1991.tb01649.x","article-title":"The role of inflammatory mediators in the pathogenesis of periodontal disease","volume":"26","author":"Page","year":"1991","journal-title":"J Periodontal Res"},{"key":"R9-20250920","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1902\/jop.2002.73.4.460","article-title":"Research, Science, and Therapy Committee of the American Academy of Periodontology. 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