{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:57:48Z","timestamp":1788785868680,"version":"build-2803163510"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"\n Introduction:<\/jats:title>\n \n Oral and oropharyngeal cancers together are the 6\n th<\/jats:sup>\n most common cancers in the world and more than 90% are squamous cell carcinomas (OSCC, OPSCC). HPV is an important risk factor. p16 expression apart from indirectly assessing HPV infection, is an independent favorable prognostic marker. Lewis\/Modified Lewis criteria of p16 grading identifies a subset of patients with improved overall survival.\n <\/jats:p>\n <\/jats:sec>\n \n Aims:<\/jats:title>\n (1) To evaluate p16 expression in these cancers. (2) To correlate p16 expression with age, gender, sub-site, histological type and grade. (3) To utilize the Lewis\/modified Lewis criteria.<\/jats:p>\n <\/jats:sec>\n \n Methodology:<\/jats:title>\n \n The study included 70 cases of OSSC's and OPSCC's. Histological features were analyzed. p16 expression was determined and graded. Results were analyzed and evaluated using Chi-square test (value of\n P<\/jats:italic>\n < 0.05 was taken significant).\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n p16 positivity was seen in 46\/70 (66%) cases (44 OSCC & 26 OPSCC). It was more frequent in younger patients and significantly higher in males. There was no correlation between degree of differentiation and p16 expression. In OSCC, 72.7% were p16 positive, mostly from tongue, buccal mucosa, and hard palate. p16 positivity was seen in 53.8% of OPSCCs, mostly from base of tongue and tonsil. Also, 30.4% of all cases could be included in Lewis criteria and 39.1% in modified Lewis criteria.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n p16 is an inexpensive, easily available marker, it may be incorporated routinely in all histologically diagnosed cases of OSCC and OPSCC.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jomfp.jomfp_278_22","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T05:21:23Z","timestamp":1682486483000},"page":"376-381","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of p16 expression in oral and oropharyngeal squamous cell 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