{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:21:38Z","timestamp":1787844098207,"version":"build-2784847793"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Oral submucous fibrosis (OSMF) is a potentially malignant disorder of oral mucosa and its malignant transformation rate accounts to about 7%\u201313%. Oxidative damage and lipid peroxidation plays an important role in OSMF. Lipid peroxidation has not been widely investigated in OSMF patients with respect to clinical staging and histopathological grading. As human saliva is a diagnostic fluid which can be obtained in a noninvasive procedure as compared to the blood for serum analysis, the present study was aimed at evaluating the salivary malondialdehyde (MDA) levels in OSMF and comparison with respect to clinical staging and histopathological grading.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>This study aims to evaluate salivary MDA levels in OSMF and compare the levels with respect to clinical and histopathological grading systems.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Forty cases of clinically diagnosed and histopathologically proven cases of OSMF were included for the purpose of this study. As controls 40 age-matched individuals without any systemic disease were selected. Unstimulated whole saliva was collected from each individual, centrifuged and frozen at \u2212 20\u00b0C until analysis. Lipid peroxidation products MDA were analyzed by thiobarbituric acid reaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Salivary MDA levels were significantly increased in OSMF patients compared to controls. The progressively increased salivary MDA levels showed a positive correlation with the clinical stages and histopathological grades of OSMF and the results were statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The increased salivary MDA levels in OSMF patients compared to the control group suggests an increased oxidative stress levels in the potentially malignant disorders such as OSMF. The mean salivary MDA levels were increased significantly as the clinical stage and histopathological grade of OSMF advances, suggesting MDA to be used as a reliable biochemical marker and also a prognostic marker to assess the extent of oxidative damage in OSMF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jomfp.jomfp_279_18","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T11:09:35Z","timestamp":1624878575000},"page":"82-87","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Salivary malondialdehyde in oral submucous fibrosis \u2013 A marker for oxidative damage"],"prefix":"10.4103","volume":"25","author":[{"given":"Shyam Raj","family":"Ganta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samatha","family":"Chittemsetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taneeru","family":"Sravya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkateswara Rao","family":"Guttikonda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-18-20240906","first-page":"152","article-title":"A clinical profile of Oral Submucous Fibrosis","volume":"3","author":"Modi","year":"2012","journal-title":"NJIRM"},{"key":"R3-18-20240906","doi-asserted-by":"crossref","first-page":"24","DOI":"10.5005\/jp-journals-10011-1254","article-title":"Classification system for Oral Submucous Fibrosis","volume":"24","author":"More","year":"2012","journal-title":"J Indian Acad Oral Med Radiol"},{"key":"R4-18-20240906","first-page":"39","article-title":"Oral submucous fibrosis \u2013 Current Concepts in Etiopathogenesis","volume":"1","author":"Gupta","year":"2008","journal-title":"Peoples J Sci Res"},{"key":"R5-18-20240906","doi-asserted-by":"crossref","first-page":"106","DOI":"10.4103\/0970-9290.33785","article-title":"Oral submucous fibrosis: A clinico-histopathological study in Chennai","volume":"18","author":"Kiran Kumar","year":"2007","journal-title":"Indian J Dent Res"},{"key":"R6-18-20240906","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.oraloncology.2010.01.017","article-title":"Betel-quid chewing with or without tobacco is a major risk factor for oral potentially malignant disorders in Sri Lanka: A case-control study","volume":"46","author":"Amarasinghe","year":"2010","journal-title":"Oral Oncol"},{"key":"R7-18-20240906","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1080\/09723757.2013.11886190","article-title":"Toxic effects of betel quid","volume":"13","author":"Adhikari","year":"2013","journal-title":"Int J Hum Genet"},{"key":"R8-18-20240906","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1080\/01926230290166724","article-title":"Oxidation of biological systems: Oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification","volume":"30","author":"Kohen","year":"2002","journal-title":"Toxicol Pathol"},{"key":"R9-18-20240906","first-page":"5","article-title":"Salivary biomarkers of oxidative stress: A critical review","volume":"4","author":"Wang","year":"2015","journal-title":"Free Radic Biol Med"},{"key":"R10-18-20240906","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1620\/tjem.206.305","article-title":"Assessment of salivary and serum antioxidant vitamins and lipid peroxidation in patients with recurrent aphthous ulceration","volume":"206","author":"Saral","year":"2005","journal-title":"Tohoku J Exp Med"},{"key":"R11-18-20240906","first-page":"7","article-title":"Use of Malondialdehyde as a biomarker for assessing oxidative stress in different disease pathologies: A review","volume":"43","author":"Singh","year":"2014","journal-title":"Iran J Publ Health"},{"key":"R12-18-20240906","doi-asserted-by":"crossref","first-page":"722","DOI":"10.4103\/0973-1482.139160","article-title":"Estimation of serum superoxide dismutase and serum malondialdehyde in oral submucous fibrosis: A clinical and biochemical study","volume":"10","author":"Avinash Tejasvi","year":"2014","journal-title":"J Cancer Res Ther"},{"key":"R13-18-20240906","first-page":"2","article-title":"Oral submucous fibrosis: Review on mechanisms of pathogenesis and malignant transformation","volume":"S5","author":"Ekanayaka","year":"2013","journal-title":"J Carcinogene Mutagene"},{"key":"R14-18-20240906","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.bbrc.2005.08.072","article-title":"Lipid peroxidation: Mechanisms, inhibition, and biological effects","volume":"338","author":"Niki","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"R15-18-20240906","doi-asserted-by":"crossref","first-page":"156","DOI":"10.4103\/0971-5851.138990","article-title":"Status of salivary lipid peroxidation in oral cancer and precancer","volume":"35","author":"Shetty","year":"2014","journal-title":"Indian J Med Paediatr Oncol"},{"key":"R16-18-20240906","doi-asserted-by":"crossref","first-page":"125","DOI":"10.4103\/1947-2714.93887","article-title":"Malondialdehyde levels in oral sub mucous fibrosis: A clinicopathological and biochemical study","volume":"4","author":"Shetty","year":"2012","journal-title":"N Am J Med Sci"},{"key":"R17-18-20240906","first-page":"100","article-title":"Salivary lipid peroxidation product malonaldehyde in various dental diseases","volume":"1","author":"Rai","year":"2006","journal-title":"World J Med Sci"},{"key":"R18-18-20240906","doi-asserted-by":"crossref","first-page":"487","DOI":"10.4103\/0973-1482.77106","article-title":"Estimation of serum malondialdehyde in oral cancer and precancer and its association with healthy individuals, gender, alcohol, and tobacco abuse","volume":"6","author":"Chole","year":"2010","journal-title":"J Cancer Res Ther"},{"key":"R19-18-20240906","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2334\/josnusd.56.135","article-title":"Evaluation of salivary and serum lipid peroxidation, and glutathione in oral leukoplakia and oral squamous cell carcinoma","volume":"56","author":"Metgud","year":"2014","journal-title":"J Oral Sci"},{"key":"R20-18-20240906","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/BF02872409","article-title":"Role of oxidative stress and antioxidants in aetiopathogenesis and management of oral submucous fibrosis","volume":"19","author":"Gupta","year":"2004","journal-title":"Indian J Clin Biochem"},{"key":"R21-18-20240906","doi-asserted-by":"crossref","first-page":"448","DOI":"10.4103\/0976-237X.107438","article-title":"Estimation of serum malondialdehyde in potentially malignant disorders and post-antioxidant treated patients: A biochemical study","volume":"3","author":"D'souza","year":"2012","journal-title":"Contemp Clin Dent"},{"key":"R22-18-20240906","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4103\/0973-029X.33960","article-title":"An estimation of serum malondialdehyde, superoxide dismutase and vitamin A in oral submucous fibrosis and its clinicopathologic correlation","volume":"11","author":"Metkari","year":"2007","journal-title":"J Oral Maxillofac Pathol"}],"container-title":["Journal of Oral and Maxillofacial Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.JOMFP_279_18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:05:51Z","timestamp":1787843151000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.JOMFP_279_18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/jomfp.jomfp_279_18","relation":{},"ISSN":["0973-029X"],"issn-type":[{"value":"0973-029X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}