{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:04:16Z","timestamp":1789603456517,"version":"build-2803163510"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this study is to compare the proliferative capacity and antiapoptotic capacity of unicystic ameloblastoma (UA), odontogenic keratocyst (OKC), dentigerous cyst (DC) and radicular cyst (RC) by assessing the Ki-67 labeling index (LI) and Bcl-2 LI, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Formalin-fixed, paraffin-embedded tissue blocks of twenty-three histopathologically diagnosed UAs, 6 OKCs, 8 DCs and 10 RCs were selected from the archival specimens. Five micrometer thick sections of tissue blocks of the lesions were processed for immunohistochemical staining with Ki-67 and Bcl-2. The Ki-67 LI and Bcl-2 LI were determined for the cases with a positive reaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Ki-67 expression was seen in 6 (26.1%) cases of UA, 4 (66.7%) OKC, 1 (12.5%) DC and 1 (10.0%) RC. There was a statistically significant difference between the mean Ki-67 LI of UA and OKC (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.024). Bcl-2 expression was seen in 16 (69.6%) UA, 5 (83.3%) OKC, 5 (62.5%) DC and 5 (50.0%) RC. The mean Bcl-2 LI of UA was significantly higher than that of DC (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.048). Furthermore, cases of OKC had significantly higher mean Bcl-2 LI compared to DC (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.026) and RC (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.049).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study suggests that the Ki-67 LI may help in differentiating OKC from UA. The Bcl-2 LI may be useful in differentiating UA from DCs, and differentiating OKC from DC and RC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jomfp.jomfp_289_19","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T17:16:06Z","timestamp":1600794966000},"page":"399-399","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Proliferative and anti-apoptotic indices of unicystic ameloblastoma, odontogenic keratocyst, dentigerous cyst and radicular cyst"],"prefix":"10.4103","volume":"24","author":[{"given":"Efetobo Victor","family":"Orikpete","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Oral Biology, Faculty of Dentistry, University of Port Harcourt, Port Harcourt, Rivers State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osawe Felix","family":"Omoregie","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology and Medicine, School of Dentistry, University of Benin, Benin City, Edo State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Akin","family":"Ojo","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology and Medicine, School of Dentistry, University of Benin, Benin City, Edo State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"R1-20250930","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1126\/science.3541204","article-title":"The molecular genetics of cancer","volume":"235","author":"Bishop","year":"1987","journal-title":"Science"},{"key":"R2-20250930","doi-asserted-by":"crossref","first-page":"e174","DOI":"10.4317\/medoral.18573","article-title":"Comparison of the value of PCNA and Ki-67 as markers of cell proliferation in ameloblastic tumors","volume":"18","author":"Bologna-Molina","year":"2013","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"R3-20250930","first-page":"27","article-title":"A comparative study of PCNA and Ki-67 expression in dental follicle, dentigerous cyst, unicystic ameloblastoma and ameloblastoma","volume":"2","author":"Nafarzadeh","year":"2013","journal-title":"Int J Mol Cell Med"},{"key":"R4-20250930","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1600-0714.1995.tb01207.x","article-title":"p53 protein and Ki-67 reactivity in epithelial odontogenic lesions. 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