{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:35:48Z","timestamp":1787841348189,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,1]]},"abstract":"\n Background:<\/jats:title>\n In the context of early diagnosis and prevention of oral cancer, precise assessment of malignant potentiality of the oral potentially malignant disorders, particularly oral submucous fibrosis (OSF) is crucial. Till date, the assessment of malignant potentiality suffers from predictive ambiguity due to the lack of precision in the gold standard techniques. This can be addressed by integrating heuristic domain knowledge with quantitative analysis.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n The aim of this study is to propose an index for enhancing accuracy in malignant potentiality evaluation.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n The present study analyzes important histomorphometric attributes (epithelial thickness, basal cell nuclear size, nuclear-to-cytoplasmic area ratio of basal cells, chromaticity of basal cell nucleus, thickness of basement membrane, ratio of vasculature in juxta-epithelial connective tissue [i.e., area covered by blood vessels\/total area], collagen density in the lamina propria) of oral mucosa in dysplastic and nondysplastic OSF in association with relevant oncopathological appreciations (weightage of different features as suggested by oral pathologists) toward proposing a \u201cMalignant Potentiality Index\u201d (MPI).<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Analysis of variance and notch box plot analysis depict statistically significant differences (\n P<\/jats:italic>\n < 0.0001) in the histopathological features among different study groups (normal oral mucosa, OSF without dysplasia, OSF with dysplasia). Histopathological observation of one OSF patient with calculated MPI is shown.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n This newly proposed diagnostic cum prognostic decision-making parameter, the \u201cMPI\u201d may bring a value addition to the conventional diagnostic gold standard.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jomfp.jomfp_297_19","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T15:47:24Z","timestamp":1588866444000},"page":"188-188","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Malignant potentiality assessment of oral submucous fibrosis through semi-quantitative approach"],"prefix":"10.4103","volume":"24","author":[{"given":"Mousumi","family":"Pal","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences and Research, Kharagpur, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debaleena","family":"Nawn","sequence":"additional","affiliation":[{"name":"Advanced Technology Development Centre, Indian Institute of Technology, Kharagpur, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Lahiri","sequence":"additional","affiliation":[{"name":"School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debnath","family":"Das","sequence":"additional","affiliation":[{"name":"School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjan Rashmi","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences and Research, Kharagpur, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debjani","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Indian Institute of Technology, Kharagpur, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,5,8]]},"reference":[{"key":"R2-20250920","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3126\/nje.v6i4.17255","article-title":"Changing trends in oral cancer \u2013 A global scenario","volume":"6","author":"Gupta","year":"2016","journal-title":"Nepal J Epidemiol"},{"key":"R3-20250920","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/ijc.28754","article-title":"Potentially malignant disorders of the oral cavity: Current practice and future directions in the clinic and laboratory","volume":"136","author":"Dionne","year":"2015","journal-title":"Int J 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of the oral mucosa \u2013 Diagnostic problems and prognostic features","volume":"12","author":"Bouquot","year":"2006","journal-title":"Curr Diagn Pathol"},{"key":"R10-20250920","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2147\/vhrm.2006.2.3.213","article-title":"Angiogenesis in cancer","volume":"2","author":"Nishida","year":"2006","journal-title":"Vasc Health Risk Manag"},{"key":"R11-20250920","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/nmat4009","article-title":"Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium","volume":"13","author":"Chaudhuri","year":"2014","journal-title":"Nat Mater"}],"container-title":["Journal of Oral and Maxillofacial 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