{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:31:47Z","timestamp":1787776307147,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,9]]},"abstract":"\n Introduction:<\/jats:title>\n Malignant tumors of sinonasal tract are extremely rare and comprise 3% of all head and neck malignant tumors. They constitute 0.2% of all invasive carcinomas. Sinonasal space is a small anatomical place, but is the site of origin for tumors with diverse histological features. Many of the tumors are similar to those that occur in various parts of the body and have overlapping histological features. A panel of immunohistochemical (IHC) markers is essential to diagnose these tumors. Most of the tumors arise in the maxillary sinus followed by ethmoid sinus. History and complete head and neck examination along with biopsy are mandatory for evaluating the disease.<\/jats:p>\n <\/jats:sec>\n \n Aim and Objectives:<\/jats:title>\n To study the age-, sex- and site-wise incidence of different malignant lesions of the nasal cavity and paranasal sinuses. To subtype and classify the malignant tumors as per the WHO guidelines.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n Forty-seven cases of sinonasal tumors reported over a period of 3 years were retrieved from the archives of the department of pathology. The tissues were subjected to paraffin processing and stained with hematoxylin and eosin. IHC was done with a panel of markers, wherever necessary.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n The present study included a total of 47 malignant lesions. Of which, 24 cases (51.06%) were squamous cell carcinomas (five cases each of well-differentiated SCC and moderately differentiated SCC and 14 cases of nonkeratinizing SCC). Five (10.63%) cases each were of neuroendocrine carcinoma and non-Hodgkin's lymphoma.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Malignant neoplasms of sinonasal tract have overlapping clinical and pathological findings; establishing the correct diagnosis is difficult without using a panel of IHC markers.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jomfp.jomfp_300_18","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T05:33:16Z","timestamp":1578461596000},"page":"378-382","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":16,"title":["Diagnostic challenges in malignant tumors of nasal cavity and paranasal sinuses"],"prefix":"10.4103","volume":"23","author":[{"given":"C. Padmavathi","family":"Devi","sequence":"first","affiliation":[{"name":"Department of Pathology, Guntur Medical College, Guntur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Maruthi","family":"Devi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Guntur Medical College, Guntur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Guntur Medical College, Guntur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. V.","family":"Amrutha Sindhu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Guntur Medical College, Guntur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-20250525","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/nrclinonc.2014.97","article-title":"Sinonasal carcinoma: Clinical, pathological, genetic and therapeutic advances","volume":"11","author":"Llorente","year":"2014","journal-title":"Nat Rev Clin Oncol"},{"key":"R3-20250525","first-page":"FC04","article-title":"Clinico-pathological study of space occupying lesions of nasal cavity, paranasal sinuses and nasopharynx","volume":"8","author":"Garg","year":"2014","journal-title":"J Clin Diagn Res"},{"key":"R4-20250525","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/01.pap.0000163958.29032.56","article-title":"Sinonasal undifferentiated carcinoma: Clinical and pathologic features and a discussion on classification, cellular differentiation, and differential diagnosis","volume":"12","author":"Ejaz","year":"2005","journal-title":"Adv Anat Pathol"},{"key":"R5-20250525","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4103\/0976-9668.95986","article-title":"Sino nasal undifferentiated carcinoma: A rare entity","volume":"3","author":"Goel","year":"2012","journal-title":"J Nat Sci Biol Med"},{"key":"R6-20250525","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s12105-016-0694-9","article-title":"Sinonasal adenocarcinoma: Update on classification, immunophenotype and molecular features","volume":"10","author":"Leivo","year":"2016","journal-title":"Head Neck Pathol"},{"key":"R7-20250525","first-page":"70","article-title":"Study of lesions of nasal cavity, nasopharynx and paranasal sinuses by histopathological examination","volume":"67","author":"Shah","year":"2012","journal-title":"Gujarat Med J"},{"key":"R8-20250525","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1097\/00000478-199911000-00006","article-title":"Sinonasal lymphoma: A clinicopathologic analysis of 58 cases from the massachusetts general hospital","volume":"23","author":"Cuadra-Garcia","year":"1999","journal-title":"Am J Surg Pathol"},{"key":"R9-20250525","doi-asserted-by":"crossref","first-page":"699","DOI":"10.5858\/133.5.699","article-title":"Undifferentiated malignant neoplasms of the sinonasal tract","volume":"133","author":"Wenig","year":"2009","journal-title":"Arch Pathol Lab Med"},{"key":"R10-20250525","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4236\/ijohns.2013.21005","article-title":"Sinonasal adenocarcinoma experience of an oncology center","volume":"2","author":"Bernardo","year":"2013","journal-title":"Int J Otolaryngol Head Neck Surg"},{"key":"R11-20250525","doi-asserted-by":"crossref","first-page":"28","DOI":"10.4103\/0377-4929.59179","article-title":"Sinonasal malignancies with neuroendocrine differentiation: Case series and review of literature","volume":"53","author":"Menon","year":"2010","journal-title":"Indian J Pathol Microbiol"}],"container-title":["Journal of Oral and Maxillofacial Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.JOMFP_300_18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:06:06Z","timestamp":1787774766000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.JOMFP_300_18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.4103\/jomfp.jomfp_300_18","relation":{},"ISSN":["0973-029X","1998-393X"],"issn-type":[{"value":"0973-029X","type":"print"},{"value":"1998-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"2018-12-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-04","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}