{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:05:26Z","timestamp":1788329126644,"version":"build-2803163510"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic toggle=\"yes\">bcl-2<\/jats:italic>\n                      proto-oncogene was discovered at the chromosomal breakpoint of t (14;18) found in follicular lymphoma. Histological changes in dysplasia are considered the earliest signs preceding the progression into squamous cell carcinoma. Serving as critical regulators of apoptotic pathways,\n                      <jats:italic toggle=\"yes\">bcl-2<\/jats:italic>\n                      prohibits programmed cell death and subsequently assists in uncontrolled neoplastic growth.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings and Design:<\/jats:title>\n                    <jats:p>\n                      This study included 48 cases, eight each of epithelial dysplasia and squamous cell carcinoma. Immunohistochemical staining using\n                      <jats:italic toggle=\"yes\">bcl-2<\/jats:italic>\n                      antibody was performed and different histological parameters were correlated with\n                      <jats:italic toggle=\"yes\">bcl-2<\/jats:italic>\n                      positive cells in all the cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      All 3\n                      <jats:italic toggle=\"yes\">\u03bc<\/jats:italic>\n                      m thick sections were stained with\n                      <jats:italic toggle=\"yes\">bcl-2<\/jats:italic>\n                      antibody. After identifying four representative fields at 40x, their images were obtained for assessment of\n                      <jats:italic toggle=\"yes\">bcl-2<\/jats:italic>\n                      labelled cells and their intensity along with different histological parameters in all the cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Analysis:<\/jats:title>\n                    <jats:p>\n                      The differences between different histological parameters were analysed using the Anova test, post hoc test and Bonferroni test. Pearson's Chi-square test was carried out to determine the level of correlation between the\n                      <jats:italic toggle=\"yes\">bcl-2<\/jats:italic>\n                      positive cells in both epithelial dysplasia and oral squamous cell carcinoma cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Sequential increase in the bcl-2 expression was observed in increasing grades of epithelial dysplasia, whereas bcl-2 expression was significantly decreased in ascending stages of squamous cell carcinoma thus, suggesting a possible role of bcl-2 in disease progression from premalignancy to malignancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jomfp.jomfp_326_21","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T05:21:23Z","timestamp":1682486483000},"page":"316-321","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["To analyse the mitotic and keratinisation correlation with bcl-2 expression in varying grades of oral epithelial dysplasia and squamous cell carcinoma"],"prefix":"10.4103","volume":"26","author":[{"given":"Aparna","family":"Pathak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devi Charan","family":"Shetty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghu","family":"Dhanapal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetpriya","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-8-20240906","first-page":"92","article-title":"Immunohistochemical expression of Bcl-2 in oral squamous cell carcinoma","volume":"18","author":"Muthukumaran","year":"2009","journal-title":"IOSR J Dent Med Sci"},{"key":"R2-8-20240906","doi-asserted-by":"crossref","first-page":"a019505","DOI":"10.1101\/cshperspect.a019505","article-title":"Epigenetic determinants of cancer","volume":"8","author":"Baylin","year":"2016","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"R3-8-20240906","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.oraloncology.2003.09.012","article-title":"Induction of apoptosis in oral cancer cells: Agents and mechanisms for potential therapy and prevention","volume":"40","author":"Hsu","year":"2004","journal-title":"Oral Oncol"},{"key":"R4-8-20240906","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1177\/154405910808700104","article-title":"Molecular pathogenesis of oral squamous cell carcinoma: Implications for therapy","volume":"87","author":"Choi","year":"2008","journal-title":"J Dent Res"},{"key":"R5-8-20240906","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S1368-8375(02)00002-7","article-title":"Decreased expression of bcl-2 in moderate and severe oral epithelial dysplasias","volume":"38","author":"Loro","year":"2002","journal-title":"Oral Oncol"},{"key":"R6-8-20240906","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrm2308","article-title":"The BCL-2 protein family: Opposing activities that mediate cell death","volume":"9","author":"Youle","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"R7-8-20240906","first-page":"283","article-title":"Expression of bcl-2 oncoprotein in oral squamous cell carcinoma \u2013 An immunohistochemical study. 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