{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T13:24:00Z","timestamp":1788009840686,"version":"build-2784847793"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Bacteria and their products involved in periodontitis evoke an immunoinflammatory response in the host tissue. Inflammatory diseases, such as periodontitis, are often not just a local event, but may have systemic ramifications, including elevations in the numbers of circulating leukocytes, acute-phase proteins and oxidative stress markers. It is now emerging that also erythrocytes are affected by chronic inflammatory diseases. This phenomenon, named \u201canemia of inflammation,\u201d is not caused by marrow deficiencies or other diseases. The present study aimed to assess whether there was any relation between chronic periodontitis and hematological parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      A total of 80 patients were included in the study and were divided into the healthy and periodontitis groups. Blood sample was obtained from each participant for hematological analysis of leukocytes, erythrocytes, platelets, red blood cell (RBC) distribution width (RDW), mean corpuscular volume (MCV), platelet count and neutrophil\u2013leukocyte ratio (NLR). Further, the values were gathered and subjected to statistical analysis. Unpaired\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test was performed to assess the statistical significance between the groups and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05 and &lt; 0.001 were considered to be statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Results show statistically significant difference seen in leukocytes, lymphocytes, RDW, MCV, platelet count and NLR which was higher in patients with periodontitis, all other parameters are nonsignificant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Thus, within limitations, it can be concluded that increased levels of leukocytes, lymphocytes, RDW, MCV, platelet count and NLR depict the inflammatory state and destructive nature of periodontitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jomfp.jomfp_349_21","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:46:43Z","timestamp":1648687603000},"page":"77-81","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":19,"title":["Comparison of blood parameters between periodontitis patients and healthy participants: A cross-sectional hematological study"],"prefix":"10.4103","volume":"26","author":[{"given":"Hirak S","family":"Bhattacharya","sequence":"first","affiliation":[{"name":"Department of Periodontology and Implantology, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishabh","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Implantology, Kothiwal Dental College and Research Centre, Moradabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiva Shankar","family":"Gummaluri","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Implantology, Sree Sai Dental College and Research Institute, Srikakulam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manvi Chandra","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Implantology, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopaedics, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhusudan S","family":"Astekar","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology and Microbiology, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,3,31]]},"reference":[{"key":"R1-20250525","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1600-051X.1986.tb01485.x","article-title":"Pathogenesis of periodontic","volume":"13","author":"Listgarten","year":"1986","journal-title":"J Clin Periodontol"},{"key":"R2-20250525","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1902\/jop.2010.100079","article-title":"Evaluation of blood parameters in patients with chronic periodontitis for signs of anemia","volume":"81","author":"Gokhale","year":"2010","journal-title":"J Periodontol"},{"key":"R3-20250525","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1902\/jop.2010.100336","article-title":"Anemia of chronic disease and chronic periodontitis: Does periodontal therapy have an effect on anemic status?","volume":"82","author":"Pradeep","year":"2011","journal-title":"J Periodontol"},{"key":"R4-20250525","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1177\/003693309303800304","article-title":"Dental disease, fibrinogen and white cell count; 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