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MMP family proteins elicit a dual role in the pathogenesis of inflammation, stimulating protective innate and\/or adaptive immune functions, as well as tissue destruction. The main organic component of tooth structure is collagen, and MMPs that degrade collagen and the extracellular matrix have been implicated in the progression of dental caries, dental erosion as well as degradation of the hybrid layer. MMPs have also been shown to be active in pulpitis, and studies have shown that they can be used as diagnostic markers of pulpal and periapical inflammation. This review describes the role of MMPs in dental caries, dental erosion, bond stability as well as in pulpal and periapical inflammation.<\/jats:p>","DOI":"10.4103\/jomfp.jomfp_34_20","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T17:16:06Z","timestamp":1600794966000},"page":"352-360","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":33,"title":["Extracellular matrix degradation by host matrix metalloproteinases in restorative dentistry and endodontics: An overview"],"prefix":"10.4103","volume":"24","author":[{"given":"V P","family":"Anshida","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Vokkaligara Sangha Dental College and Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R Anitha","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Vokkaligara Sangha Dental College and Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chethana S","family":"Murthy","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Vokkaligara Sangha Dental College and Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoop","family":"Samuel","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Noorul Islam College of Dental Sciences, Thiruvananthapuram, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"R1-20250930","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1073\/pnas.48.6.1014","article-title":"Collagenolytic activity in amphibian tissues: A tissue culture assay","volume":"48","author":"Gross","year":"1962","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R2-20250930","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/0005-2744(68)90010-7","article-title":"Human skin collagenase. 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