{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:45:22Z","timestamp":1787071522417,"version":"build-2736575974"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Vitamin B\n                      <jats:sub>12<\/jats:sub>\n                      is a water-soluble vitamin involved in the metabolism of every cell of the human body especially affecting DNA synthesis, fatty acid and amino acid metabolism. Deficiency of this vitamin is usually associated with megaloblastic anaemia, neuropathies or pernicious anaemia. The deficiency most often goes unrecognized because the clinical manifestations are highly variable, often subtle and non-specific. The study of plasma Vitamin B\n                      <jats:sub>12<\/jats:sub>\n                      levels in oral potentially malignant disorders (OPMDs), when observed may assist in early detection and prevention of these lesions. Hence the present study was conducted to assess and compare the plasma Vitamin B\n                      <jats:sub>12<\/jats:sub>\n                      levels in individuals with and without oral potentially malignant disorders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>\n                      To assess and compare the plasma Vitamin B\n                      <jats:sub>12<\/jats:sub>\n                      levels in individuals with no oral lesions and individuals with oral potentially malignant disorders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Systemically healthy individuals in the age group of 30 years\u201360 years of either gender with no oral lesions and those clinically diagnosed with oral potentially malignant disorders were selected for the study and grouped as Group A (30 individuals with no oral lesions) and Group B (30 individuals clinically diagnosed OPMDs). Plasma Vitamin B\n                      <jats:sub>12<\/jats:sub>\n                      levels were assessed using Electrochemiluminescence immunoassay.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The Vitamin B\n                      <jats:sub>12<\/jats:sub>\n                      levels in Group A ranged between 224 and 913, while that in Group B ranged between 90 and 299; clearly indicating a decrease in the levels of Vitamin B\n                      <jats:sub>12<\/jats:sub>\n                      in individuals with OPMDs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Plasma Vitamin B\n                      <jats:sub>12<\/jats:sub>\n                      in individuals with oral potentially malignant disorders were decreased as compared to individuals with no oral lesions.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jomfp.jomfp_355_25","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T08:00:35Z","timestamp":1775116835000},"page":"153-159","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Rekindling the role of plasma Vitamin B12 levels in individuals with and without oral potentially malignant disorders (OPMDs): An observational study"],"prefix":"10.4103","volume":"30","author":[{"given":"Shamolie S","family":"Deshmukh","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Bharati Vidyapeeth Deemed to be University Dental College and Hospital, Satara Road, Katraj, Dhankawadi, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rizwan M","family":"Sanadi","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dr GD Pol Dental College and Hospital, PG Institute, Kharghar, Sector \u2013 4, Navi Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Revati S","family":"Deshmukh","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Bharati Vidyapeeth Deemed to be University Dental College and Hospital, Satara Road, Katraj, Dhankawadi, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenal","family":"Tepan","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Bharati Vidyapeeth Deemed to be University Dental College and Hospital, Satara Road, Katraj, Dhankawadi, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya N","family":"Deo","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Bharati Vidyapeeth Deemed to be University Dental College and Hospital, Satara Road, Katraj, Dhankawadi, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakhar","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Sinhgad Dental College and Hospital, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"R4-20260420","first-page":"155","article-title":"Vitamin B12 deficiency in the elderly: Is it worth screening?","volume":"21","author":"Wong","year":"2015","journal-title":"Hong Kong Med J"},{"key":"R5-20260420","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/jppr.1897","article-title":"Vitamin B12 deficiency in older people: A practical approach to recognition and management","volume":"53","author":"Mouchaileh","year":"2023","journal-title":"J Pharm Pract Res"},{"key":"R6-20260420","doi-asserted-by":"crossref","first-page":"145","DOI":"10.7861\/clinmedicine.15-2-145","article-title":"Vitamin B12 deficiency \u2013 A 21st century perspective","volume":"15","author":"Shipton","year":"2015","journal-title":"J Clin Med"},{"key":"R7-20260420","first-page":"e87830","article-title":"Assessment of patient knowledge and potential screening gaps in vitamin b12 deficiency","volume":"17","author":"Lippmann","year":"2025","journal-title":"Cureus"},{"key":"R10-20260420","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fmed.2016.00038","article-title":"Oral vitamin B12 replacement for the treatment of pernicious anaemia","volume":"3","author":"Chan","year":"2016","journal-title":"Front Med"},{"key":"R11-20260420","doi-asserted-by":"crossref","first-page":"e386","DOI":"10.4317\/medoral.20205","article-title":"Oral potentially malignant disorders: Is malignant transformation predictable and preventable?","volume":"17","author":"van der Waal","year":"2014","journal-title":"Med Oral Patol Oral Cir"},{"key":"R12-20260420","doi-asserted-by":"crossref","first-page":"326","DOI":"10.4103\/jomfp.JOMFP_224_17","article-title":"Oral potentially malignant disorders: Revisited","volume":"21","author":"Ray","year":"2017","journal-title":"J Oral Maxillofac Pathol"},{"issue":"Suppl","key":"R13-20260420","first-page":"36","article-title":"Assessment of serum vitamin B12 and folic acid in patients with oral lichen planus: A case control study","volume":"10","author":"Sahebjamee","year":"2010","journal-title":"J Dent (Shiraz University of Medical Sciences)"},{"key":"R15-20260420","doi-asserted-by":"crossref","first-page":"100563","DOI":"10.1016\/j.obmed.2024.100563","article-title":"Vitamin B12: A cornerstone of cognitive and metabolic well-being in young adults","volume":"53","author":"Sharma","year":"2025","journal-title":"Obes. Med"},{"key":"R16-20260420","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.jobcr.2020.07.010","article-title":"Reduced levels of serum vitamin B12 in symptomatic cases of oral lichen planus: A cross-sectional study","volume":"10","author":"Naik","year":"2020","journal-title":"J Oral Biol Craniofac Res"},{"key":"R17-20260420","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.nutos.2024.05.011","article-title":"Vitamin B12 levels in patients with oral mucosal diseases (OMD): A systematic review","volume":"56","author":"Putri","year":"2024","journal-title":"Clin Nutr Open Sci"},{"key":"R18-20260420","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.jfma.2019.05.016","article-title":"Significantly higher frequencies of hematinic deficiencies and hyperhomocysteinemia in oral precancer patients","volume":"118","author":"Wu","year":"2019","journal-title":"J Formos Med Assoc"},{"key":"R19-20260420","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/s12903-020-01229-w","article-title":"The profile of hematinic deficiencies in patients with oral lichen planus: A case-control study","volume":"20","author":"Bao","year":"2020","journal-title":"BMC Oral Health"},{"key":"R20-20260420","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jds.2018.02.001","article-title":"Hematinic deficiencies and anaemia in gastric parietal cell antibody-positive and -negative oral submucous fibrosis patients","volume":"13","author":"Chiang","year":"2018","journal-title":"J Dent Sci"},{"key":"R21-20260420","doi-asserted-by":"crossref","first-page":"575","DOI":"10.4103\/jomfp.JOMFP_65_20","article-title":"Evaluation of hematological profile in oral submucous fibrosis: A cross-sectional study","volume":"24","author":"Patil","year":"2020","journal-title":"J Oral Maxillofac Pathol"},{"key":"R22-20260420","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0030-4220(89)90307-1","article-title":"Oral epithelial dysplasia in vitamin B12 deficiency","volume":"67","author":"Theaker","year":"1989","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"R23-20260420","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1186\/s40064-016-2252-z","article-title":"Holotranscobalamin (HoloTC, Active-B12) and Herbert\u2019s model for the development of vitamin B12 deficiency: A review and alternative hypothesis","volume":"5","author":"Golding","year":"2016","journal-title":"Springerplus"},{"key":"R24-20260420","first-page":"e17918","article-title":"Association between metformin dose and vitamin B12 deficiency in patients with type 2 diabetes","volume":"98","author":"Kim","year":"2019","journal-title":"N Engl J Med"},{"key":"R25-20260420","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3390\/pharmaceutics10010036","article-title":"Evidence of drug-nutrient interactions with chronic use of commonly prescribed medications: An update","volume":"10","author":"Mohn","year":"2018","journal-title":"Pharmaceutics"},{"key":"R26-20260420","doi-asserted-by":"crossref","first-page":"42","DOI":"10.25100\/cm.v44i1.793","article-title":"Vitamin B12 deficit and development of geriatric syndromes","volume":"44","author":"Ocampo","year":"2013","journal-title":"Colombia Medica"},{"key":"R27-20260420","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3390\/nu2030299","article-title":"Vitamin B12 in Health and Disease","volume":"2","author":"O\u2019Leary","year":"2010","journal-title":"Nutrients"},{"key":"R28-20260420","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/10408363.2021.1885339","article-title":"Vitamin B12 status in health and disease: A critical review. Diagnosis of deficiency and insufficiency-clinical and laboratory pitfalls","volume":"58","author":"Sobczy\u0144ska-Malefora","year":"2021","journal-title":"Crit Rev Clin Lab Sci"},{"key":"R29-20260420","doi-asserted-by":"crossref","first-page":"109931","DOI":"10.1016\/j.ijscr.2024.109931","article-title":"Oral manifestations of vitamin B12 deficiency associated with pernicious anaemia: A case report","volume":"121","author":"Boukssim","year":"2024","journal-title":"Int J Surg Case Rep"},{"key":"R30-20260420","doi-asserted-by":"crossref","first-page":"1279220","DOI":"10.3389\/fcimb.2024.1279220","article-title":"What can we learn from treatments of oral lichen planus?","volume":"14","author":"Wu","year":"2024","journal-title":"Front Cell Infect Microbiol"}],"container-title":["Journal of Oral and Maxillofacial Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.jomfp_355_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:47:26Z","timestamp":1787068046000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.jomfp_355_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/jomfp.jomfp_355_25","relation":{},"ISSN":["0973-029X","1998-393X"],"issn-type":[{"value":"0973-029X","type":"print"},{"value":"1998-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-11-17","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-23","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}