{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:42:26Z","timestamp":1786653746948,"version":"build-2736575974"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"Abstract<\/jats:title>\n \n Introduction:<\/jats:title>\n \n Rose species that are well-known for their therapeutic qualities include\n Rosa chinensis, Rosa cymosa<\/jats:italic>\n , and\n Rosa indica<\/jats:italic>\n . The study employs\n in vitro<\/jats:italic>\n assays and\n in silico<\/jats:italic>\n molecular docking to investigate their phytochemical composition and antioxidant properties.\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n Phytochemicals were detected in flower petals of\n Rosa chinensis, Rosa cymosa<\/jats:italic>\n , and\n Rosa indica<\/jats:italic>\n that had been extracted using methanol. Ascorbic acid was utilised as the standard reference for assessing antioxidant activity and its hydrogen peroxide scavenging potential. Superoxide dismutase (SOD) interactions with berberine, emodin, and limonene were assessed by molecular docking using PyRx software.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Various beneficial substances were found in all species according to phytochemical investigation. Among the three Rosa species,\n R. chinensis<\/jats:italic>\n demonstrated the highest antioxidant activity, followed by\n R. cymosa<\/jats:italic>\n and\n R. indica<\/jats:italic>\n . Docking studies demonstrated that berberine and emodin had substantial binding affinity with SOD. The extracts showed strong antioxidant properties, suggesting that they could be used as naturally occurring antioxidants.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n \n Rosa chinensis, Rosa cymosa<\/jats:italic>\n , and\n Rosa indica<\/jats:italic>\n show promise as medicinal plants and have strong antioxidant properties. The results validate the development of these rose species as naturally occurring antioxidants for the treatment of ailments related with oxidative stress.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jomfp.jomfp_36_25","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T12:33:50Z","timestamp":1743338030000},"page":"41-49","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Exploring the potential of Rosa chinensis, Rosa cymosa, and Rosa indica in oral disease prevention: A multifaceted approach"],"prefix":"10.4103","volume":"29","author":[{"given":"Monisha","family":"Prasad","sequence":"first","affiliation":[{"name":"Department of Community Medicine, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lithesh M.","family":"Balasubramaniam","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malareni D. L.","family":"Priya","sequence":"additional","affiliation":[{"name":"PG Department of Biochemistry, Auxilium College (Autonomous), Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. R.","family":"Varun","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramya","family":"Sekar","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology and Oral Microbiology, Meenakshi Ammal Dental College and Hospital, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"R1-20250328","first-page":"7519687","article-title":"Insight on rosaceae family with genome sequencing and functional genomics perspective","author":"Soundararajan","year":"2019","journal-title":"Biomed Res Int 2019"},{"key":"R2-20250328","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.3390\/ijms18061137","article-title":"Therapeutic applications of rose hips from different Rosa species","volume":"18","author":"M\u00e1rmol","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"Suppl 1","key":"R3-20250328","doi-asserted-by":"crossref","first-page":"S359","DOI":"10.12980\/APJTB.4.2014C1030","article-title":"Phytochemical analysis and evaluation of leaf and root parts of the medicinal herb, Hypochaeris radicata L. for in vitro antioxidant activities","volume":"4","author":"Senguttuvan","year":"2014","journal-title":"Asian Pac J Trop Biomed"},{"key":"R4-20250328","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3390\/antiox8040092","article-title":"Polyphenolic composition of Rosa canina, Rosa sempervivens and Pyrocantha coccinea extracts and assessment of their antioxidant activity in human endothelial cells","volume":"8","author":"Kerasioti","year":"2019","journal-title":"Antioxidants (Basel)"},{"key":"R5-20250328","first-page":"4616815","article-title":"Integrating in silico and in vitro approaches to screen the antidiabetic properties from Tabernaemontana divaricata (Jasmine) flowers","author":"Muzammil","year":"2022","journal-title":"Evid Based Complement Alternat Med 2022"},{"key":"R6-20250328","doi-asserted-by":"crossref","first-page":"681","DOI":"10.3390\/antiox12030681","article-title":"Effect of the drying method and optimization of extraction on antioxidant activity and phenolic of rose petals","volume":"12","author":"Baibuch","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"R8-20250328","first-page":"497606","article-title":"Phytochemical evaluation, antimicrobial activity, and determination of bioactive components from leaves of Aegle marmelos","author":"Mujeeb","year":"2014","journal-title":"Biomed Res Int 2014"},{"key":"R9-20250328","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s12906-023-03923-y","article-title":"In vitro antioxidant and free-radical scavenging activities of polar leaf extracts of Vernonia amygdalina","volume":"23","author":"Hussen","year":"2023","journal-title":"BMC Complement Med Ther"},{"key":"R10-20250328","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1080\/14786419.2017.1331228","article-title":"Phytochemical screening, antioxidant activity, total phenolic and total flavonoid contents of seven local varieties of Rosa indica L","volume":"32","author":"Zahid","year":"2018","journal-title":"Nat Prod Res"},{"key":"R11-20250328","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12906-018-2114-z","article-title":"Phytochemical investigation and antimicrobial appraisal of Parrotiopsis jacquemontiana (Decne) Rehder","volume":"18","author":"Ali","year":"2018","journal-title":"BMC Complement Altern Med"},{"key":"R12-20250328","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.3390\/molecules27041326","article-title":"Determination of antioxidants by DPPH radical scavenging activity and quantitative phytochemical analysis of Ficus religiosa","volume":"27","author":"Baliyan","year":"2022","journal-title":"Molecules"},{"key":"R13-20250328","first-page":"e60354","article-title":"Calotropis procera and the pharmacological properties of its aqueous leaf extract: A review","volume":"16","author":"Habeeb","year":"2024","journal-title":"Cureus"},{"key":"R14-20250328","doi-asserted-by":"crossref","first-page":"127242","DOI":"10.1016\/j.ijbiomac.2023.127242","article-title":"Piperine modulates IR\/Akt\/GLUT4 pathways to mitigate insulin resistance: Evidence from animal and computational studies","volume":"253","author":"Prasad","year":"2023","journal-title":"Int J Biol Macromol"},{"key":"R15-20250328","doi-asserted-by":"crossref","first-page":"e412","DOI":"10.5001\/omj.2022.33","article-title":"Effects of topical application and oral intake of Rosa damascena on acute pain in adults: A systematic review and meta-analysis","volume":"37","author":"Koohpayeh","year":"2022","journal-title":"Oman Med J"},{"key":"R16-20250328","first-page":"93","article-title":"Flavonoids and other phenolic compounds from medicinal plants for pharmaceutical and medical aspects: An overview","volume":"5","author":"Tungmunnithum","year":"2018","journal-title":"Medicines (Basel)"},{"key":"R17-20250328","first-page":"187","article-title":"Chemical constituents and pharmacological activities of medicinal plants from Rosa genus","volume":"14","author":"Wang","year":"2022","journal-title":"Chin Herb Med"},{"key":"R18-20250328","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s13197-011-0251-1","article-title":"Genesis and development of DPPH method of antioxidant assay","volume":"48","author":"Kedare","year":"2011","journal-title":"J Food Sci Technol"},{"key":"R19-20250328","first-page":"e63813","article-title":"Anticariogenic, antidiabetic, and toxicology evaluation of the ethanolic extract of Croton bonplandianum: An in vitro study","volume":"16","author":"Kumar","year":"2024","journal-title":"Cureus"},{"key":"R20-20250328","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.mex.2015.05.001","article-title":"Optimized enzymatic colorimetric assay for determination of hydrogen peroxide (H2O2) scavenging activity of plant extracts","volume":"2","author":"Fernando","year":"2015","journal-title":"Methodsx"},{"key":"R21-20250328","doi-asserted-by":"crossref","first-page":"e25982","DOI":"10.1016\/j.heliyon.2024.e25982","article-title":"Changes in the antioxidant and anti-inflammatory activities of Rosa rugosa 'Mohong'during fermentation","volume":"10","author":"Abla","year":"2024","journal-title":"Heliyon"},{"key":"R22-20250328","doi-asserted-by":"crossref","first-page":"1269581","DOI":"10.3389\/fphar.2023.1269581","article-title":"From imbalance to impairment: The central role of reactive oxygen species in oxidative stress-induced disorders and therapeutic exploration","volume":"14","author":"Afzal","year":"2023","journal-title":"Front Pharmacol"},{"key":"R23-20250328","first-page":"e59112","article-title":"An assessment of the in vitro antioxidant activity of cobalt nanoparticles synthesized from Millettia pinnata, Butea monosperma, and Madhuca indica extracts: A comparative study","volume":"16","author":"Ryntathiang","year":"2024","journal-title":"Cureus"},{"key":"R24-20250328","doi-asserted-by":"crossref","first-page":"982","DOI":"10.7150\/ijbs.12096","article-title":"Significance of antioxidant potential of plants and its relevance to therapeutic applications","volume":"11","author":"Kasote","year":"2015","journal-title":"Int J Biol Sci"}],"container-title":["Journal of Oral and Maxillofacial Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.jomfp_36_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:41:51Z","timestamp":1786650111000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.jomfp_36_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jomfp.jomfp_36_25","relation":{},"ISSN":["0973-029X","1998-393X"],"issn-type":[{"value":"0973-029X","type":"print"},{"value":"1998-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-02-05","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-20","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}