{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:23:53Z","timestamp":1787772233686,"version":"build-2784847793"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>Mucoepidermoid carcinoma (MEC) is a rare salivary gland malignancy characterized by diverse cellular components. This case report presents a unique instance of low-grade MEC in a 28-year-old female, emphasizing the importance of accurate diagnosis and tailored management. The patient exhibited a painless, enlarging lower lip swelling over a year, with imaging suggestive of a fibrolipomatous lesion. Surgical excision was successfully performed, with subsequent histopathological analysis displaying mucinous cystic spaces, varied epithelial cell types and other characteristic features consistent with MEC. The case findings aligned with hallmark MEC features are seen in established literature, highlighting the significance of precise diagnosis and grading for appropriate management. This report contributes to the understanding of MEC\u2019s varied presentations and underscores the importance of thorough: histopathological examination, lower lip, mucoepidermoid carcinoma clinical evaluation, accurate histopathological analysis and interdisciplinary collaboration. The case highlights the value of considering MEC in younger patients, even with atypical presentations, and encourages ongoing exploration of diagnostic and therapeutic strategies to improve patient outcomes.<\/jats:p>","DOI":"10.4103\/jomfp.jomfp_379_23","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T23:01:27Z","timestamp":1703113287000},"page":"780-780","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Mucoepidermoid carcinoma of the lower lip: A case report and review of literature"],"prefix":"10.4103","volume":"27","author":[{"given":"Manish","family":"Bhargava","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Manav Rachna Dental College, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitesh","family":"Vats","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Manav Rachna Dental College, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of General Pathology, OP Chaudhary Hospital, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Jaiswal","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Sardar Patel Post Graduate Institute of Dental Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,12,20]]},"reference":[{"key":"R1-20260302","doi-asserted-by":"crossref","first-page":"262","DOI":"10.17159\/2519-0105\/2017\/v72no6a3","article-title":"Oral medicine case book 75:Mucoepidermoid carcinoma of the lower lip:Review and a case report","volume":"72","author":"Manenzhe","year":"2017","journal-title":"S Afr Dent J"},{"key":"R2-20260302","doi-asserted-by":"crossref","first-page":"532","DOI":"10.17511\/jopm.2018.i07.09","article-title":"A clinicopathological study of salivary gland tumors","volume":"4","author":"Saldanha","year":"2018","journal-title":"Trop J Path Micro"},{"key":"R6-20260302","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1607-551X(09)70382-1","article-title":"Mucoepidermoid carcinoma on the vermilion border of the upper lip:A case report and literature review","volume":"23","author":"Chan","year":"2007","journal-title":"Kaohsiung J Med Sci"},{"key":"R7-20260302","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.oraloncology.2006.03.001","article-title":"Mucoepidermoid carcinoma of the salivary glands. Review of the literature and clinicopathological analysis of 18 patients","volume":"43","author":"Rapidis","year":"2007","journal-title":"Oral Oncol"},{"key":"R8-20260302","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s12105-009-0139-9","article-title":"Salivary gland tumor:A review of 599 cases in a Brazilian population","volume":"3","author":"de Oliveira","year":"2009","journal-title":"Head Neck Pathol"},{"key":"R9-20260302","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.bjoms.2008.03.020","article-title":"Salivary gland tumors:A single institution experience in India","volume":"46","author":"Subhashraj","year":"2008","journal-title":"Br J Oral Maxillofac Surg"},{"key":"R10-20260302","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1038\/modpathol.3880426","article-title":"Prognostic significance of p27 and Ki-67 expression in mucoepidermoid carcinoma of the intraoral minor salivary gland","volume":"14","author":"Okabe","year":"2001","journal-title":"Mod Pathol"},{"key":"R11-20260302","doi-asserted-by":"crossref","first-page":"490","DOI":"10.4103\/jomfp.jomfp_67_21","article-title":"Mucoepidermoid carcinoma:A retrospective clinicopathologic study of 25 cases","volume":"25","author":"Jeergal","year":"2021","journal-title":"J Oral Maxillofac Pathol"},{"key":"R12-20260302","doi-asserted-by":"crossref","first-page":"54","DOI":"10.4103\/2278-0513.149044","article-title":"Mucoepidermoid carcinoma of the lower lip:A rare site of occurrence","volume":"4","author":"Phukan","year":"2015","journal-title":"Clin Cancer Investig J"},{"key":"R13-20260302","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1093\/jjco\/hyn045","article-title":"Mucoepidermoid carcinoma of the head and neck:Clinical analysis of 43 patients","volume":"38","author":"Ozawa","year":"2008","journal-title":"Jpn J Clin Oncol"},{"key":"R14-20260302","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/0278-2391(86)90229-6","article-title":"Mucoepidermoid carcinoma of the lower lip:Report of a case","volume":"44","author":"Pizer","year":"1986","journal-title":"J Oral Maxillofac Surg"},{"key":"R15-20260302","doi-asserted-by":"crossref","first-page":"91","DOI":"10.5958\/2395-6194.2016.00025.4","article-title":"Mucoepidermoid carcinoma in young female:a case report","volume":"2","author":"Sidhu","year":"2016","journal-title":"J Oral Med Oral Surg Oral Pathol Oral Radiol"},{"key":"R16-20260302","doi-asserted-by":"crossref","first-page":"e202","DOI":"10.1016\/j.oooo.2020.04.438","article-title":"Low-grade Mucoepidermoid carcinoma of lower lip mimicking mucocele","volume":"130","author":"Silva","year":"2020","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"R17-20260302","first-page":"615948","article-title":"Mucoepidermoid carcinoma in a minor salivary gland in a child","volume":"2013","author":"Sengul","year":"2013","journal-title":"Case Rep Dent"},{"key":"R18-20260302","doi-asserted-by":"crossref","first-page":"39","DOI":"10.11604\/pamj.2015.22.39.7177","article-title":"About a rare tumor of the upper lip:The mucoepidermoid carcinoma","volume":"22","author":"Touati","year":"2015","journal-title":"Pan Afr Med J"},{"key":"R19-20260302","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s12663-013-0489-4","article-title":"Intraoral minor salivary gland tumours:A retrospective study from a dental and maxillofacial surgery centre in Salem, Tamil Nadu","volume":"13","author":"Ramesh","year":"2014","journal-title":"J Maxillofac Oral Surg"},{"key":"R20-20260302","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.joms.2005.02.021","article-title":"Intraoral minor salivary gland neoplasms:Review of 213 cases","volume":"63","author":"Yih","year":"2005","journal-title":"J Oral Maxillofac Surg"},{"key":"R21-20260302","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.oraloncology.2007.08.018","article-title":"Malignant tumors of intraoral minor salivary glands","volume":"44","author":"Copelli","year":"2008","journal-title":"Oral Oncol"},{"key":"R22-20260302","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jobcr.2014.05.003","article-title":"A review:Immunological markers for malignant salivary gland tumors","volume":"4","author":"Namboodiripad","year":"2014","journal-title":"J Oral Biol Craniofac Res"},{"key":"R23-20260302","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1097\/00000658-194511000-00005","article-title":"Muco-epidermoid tumors of salivary glands","volume":"122","author":"Stewart","year":"1945","journal-title":"Ann Surg"},{"key":"R24-20260302","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/0002-9610(78)90262-3","article-title":"Mucoepidermoid carcinoma of salivary gland origin. A clinicopathologic study of 367 cases","volume":"136","author":"Spiro","year":"1978","journal-title":"Am J Surg"},{"key":"R25-20260302","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1002\/1097-0142(19920415)69:8<2021::AID-CNCR2820690803>3.0.CO;2-7","article-title":"Mucoepidermoid carcinoma of intraoral salivary glands. Evaluation and application of grading criteria in 143 cases","volume":"69","author":"Auclair","year":"1992","journal-title":"Cancer"},{"key":"R26-20260302","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.ad.2010.04.005","article-title":"Carcinoma mucoepidermoide de labio [Mucoepidermoid carcinoma of the lip","volume":"101","author":"Garc\u00eda-Cruz","year":"2010","journal-title":"Actas Dermosifiliogr"},{"key":"R27-20260302","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jobcr.2014.11.002","article-title":"Minor salivary gland tumors in the Indian population:A series of cases over a ten-year period","volume":"4","author":"Mishra","year":"2014","journal-title":"J Oral Biol Craniofac Res"},{"key":"R28-20260302","doi-asserted-by":"crossref","first-page":"505","DOI":"10.4103\/0973-029X.190955","article-title":"Salivary duct carcinoma in the mandibular anterior region:The role of immunohistochemical markers in its definitive diagnosis","volume":"20","author":"Chandrasekar","year":"2016","journal-title":"J Oral Maxillofac Pathol"},{"key":"R29-20260302","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4103\/jiaomr.jiaomr_86_17","article-title":"Mucoepidermoid carcinoma at an uncommon location","volume":"30","author":"Suvarna","year":"2018","journal-title":"J Indian Acad Oral Med Radiol"}],"container-title":["Journal of Oral and Maxillofacial Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.jomfp_379_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:33:34Z","timestamp":1787769214000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.jomfp_379_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/jomfp.jomfp_379_23","relation":{},"ISSN":["0973-029X","1998-393X"],"issn-type":[{"value":"0973-029X","type":"print"},{"value":"1998-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"2023-08-26","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-13","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}