{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:46:38Z","timestamp":1789472798016,"version":"build-2803163510"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Fine-needle aspiration cytology (FNAC) is a sensitive, specific, cost-effective tool and has been widely used as a diagnostic tool for the management of various head-and-neck lesions. Salivary gland lesions constitute the most common head-and-neck lesions. These lesions can range from inflammatory to neoplastic, which can be either benign or malignant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The study was performed on 104 patients who presented with salivary gland swelling to the department of pathology at a tertiary care center from January 2016 to June 2020. FNAC was performed using a 22\u201324G needle, and smears were stained with Giemsa, hematoxylin and eosin and Papanicolaou stain. Histopathology was assessed on routine hematoxylin- and eosin-stained paraffin sections. The cytological and histopathological slides were studied, analyzed and correlated. Sensitivity, specificity, positive predictive value and negative predictive were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The study included 104 cases in the age range of 10\u201370 years and a mean of 45 years (\u00b116 standard deviation). There was a male preponderance with a male-to-female ratio of 1.6:1. The parotid gland was the most common site 91 (87%). On cytology, 71 (68%) were neoplastic, of which 58 (81%) were benign and 13 (19%) were malignant. Histopathological correlation was available in 36 cases (50%), 24 (67%) of which were benign and the remaining 12 (33%) were malignant. The sensitivity, specificity, positive predictive value and negative predictive value of the present study are 95%, 85%, 91% and 92%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>FNAC of the salivary gland is a safe, reliable and cost-effective technique which can be used as the first line of investigation in evaluating salivary gland lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jomfp.jomfp_496_20","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:46:43Z","timestamp":1648687603000},"page":"52-56","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Fine-needle aspiration cytology of salivary gland lesions"],"prefix":"10.4103","volume":"26","author":[{"given":"A","family":"Rameeza","sequence":"first","affiliation":[{"name":"Department of Pathology, Kempegowda Institute of Medical Science, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Hemalata","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kempegowda Institute of Medical Science, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,3,31]]},"reference":[{"key":"R1-20250525","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S1479-666X(05)80064-2","article-title":"Fine needle aspiration cytology in the management of a parotid mass: A two centre retrospective study","volume":"3","author":"Balakrishnan","year":"2005","journal-title":"Surgeon"},{"key":"R2-20250525","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1288\/00005537-199103000-00005","article-title":"Fine-needle aspiration biopsy of salivary glands","volume":"101","author":"Frable","year":"1991","journal-title":"Laryngoscope"},{"key":"R3-20250525","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/dc.20581","article-title":"Parotid gland fine-needle aspiration cytology: An approach to differential diagnosis","volume":"35","author":"David","year":"2007","journal-title":"Diagn Cytopathol"},{"key":"R4-20250525","first-page":"188","article-title":"An audit of surgery of parotid gland","volume":"77","author":"Gordon","year":"1995","journal-title":"Ann R Coll Surg Engl"},{"key":"R5-20250525","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/BF03050831","article-title":"FNAC of salivary gland lesions with histopathological correlation","volume":"58","author":"Khandekar","year":"2006","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"R6-20250525","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.18203\/2349-2902.isj20172624","article-title":"FNAC and Histopathological correlation of salivary gland lesions: An observational study","volume":"4","author":"Kakoty","year":"2017","journal-title":"Int Surg J"},{"key":"R7-20250525","doi-asserted-by":"crossref","first-page":"654","DOI":"10.3126\/jpn.v4i8.11593","article-title":"Correlation of FNAC and histopathology in diagnosis of salivary gland lesions","volume":"4","author":"Koirala","year":"2014","journal-title":"J Pathol Nepal"},{"key":"R8-20250525","first-page":"804265","article-title":"Cytohistopathological study of salivary gland lesions in bundelkhand region, uttar pradesh, India","volume":"2014","author":"Omhare","year":"2014","journal-title":"Patholog Res Int"},{"key":"R9-20250525","first-page":"127","article-title":"Cytological and histopathological correlation of salivary gland lesions","volume":"6","author":"Sikdar","year":"2018","journal-title":"JMSRC"},{"key":"R10-20250525","first-page":"299","article-title":"Salivary gland tumors: A 15 year review at dental centre Lagos university teaching hospital","volume":"36","author":"Ladeinde","year":"2007","journal-title":"Afr J Med Med Sci"},{"key":"R11-20250525","first-page":"65","article-title":"Diagnosis of parotid gland mass by fine needle aspiration cytology (FNAC) and it's histopathological correlation-2 year study in BSMMU, Dhaka","volume":"4","author":"Choudhury","year":"2011","journal-title":"BSMMU J"},{"key":"R12-20250525","first-page":"32","article-title":"A cytopathological study of salivary gland lesions with histopathological correlation at tertiary health care centre","volume":"4","author":"Ramana","year":"2017","journal-title":"Med Pulse Int J Pathol"},{"key":"R13-20250525","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2739\/kurumemedj.53.23","article-title":"Comparison of preoperative fine-needle aspiration cytology diagnosis and histopathology diagnosis of salivary gland tumors","volume":"53","author":"Mihashi","year":"2006","journal-title":"Kurume Med J"},{"key":"R14-20250525","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/dc.20951","article-title":"Pleomorphic adenoma: Cytologic variations and potential diagnostic pitfalls","volume":"37","author":"Handa","year":"2009","journal-title":"Diagn Cytopathol"},{"key":"R15-20250525","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/cncy.21249","article-title":"The cytological features of mammary analogue secretory carcinoma: A series of 6 molecularly confirmed cases","volume":"121","author":"Griffith","year":"2013","journal-title":"Cancer Cytopathol"},{"key":"R16-20250525","first-page":"470","article-title":"A cytological and histological comparative study of salivary gland lesions at tertiary health care centre","volume":"6","author":"Upasana","year":"2015","journal-title":"Int J Biomed Adv Res"}],"container-title":["Journal of Oral and Maxillofacial Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.jomfp_496_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:04:30Z","timestamp":1787774670000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.jomfp_496_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/jomfp.jomfp_496_20","relation":{},"ISSN":["0973-029X","1998-393X"],"issn-type":[{"value":"0973-029X","type":"print"},{"value":"1998-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2020-12-06","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-20","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}