{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:40:17Z","timestamp":1786650017940,"version":"build-2736575974"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:p>Osteosarcoma (OS), also referred to as osteogenic sarcoma, is the most common primary malignant tumour affecting long bones, characterised by the proliferation of osteoblastic precursor cells and the production of osteoid or immature bone. OSs of the head and neck region have unique biology, exhibiting a clinical behaviour and a natural history that are distinct from OSs of the trunk and extremities. Similarly, their radiological appearance and histological growth pattern can be quite diverse proving to be a challenge to histopathologists to arrive at a diagnosis. Hence, OSs of the jaw remain enigmatic, and a number of difficulties related to their diagnosis and treatment are yet to be resolved. This article reports on a case of advanced OS of the mandible in a 45-year-old woman who came for the evaluation of swelling. This case illustrates the various modalities of diagnosis, such as radiology, histopathology and immunohistochemistry for the confirmation of the variants of OS, leading to an enormously improved quality of life by offering an improved opportunity for cure and treatment.<\/jats:p>","DOI":"10.4103\/jomfp.jomfp_496_22","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T19:52:45Z","timestamp":1725652365000},"page":"573-578","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Fibroblastic osteosarcoma: A perplexing entity"],"prefix":"10.4103","volume":"27","author":[{"given":"Komal Preet","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Science and Research, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanchita","family":"Kundu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Science and Research, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunit","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Science and Research, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mousumi","family":"Pal","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Science and Research, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,9,12]]},"reference":[{"key":"R1-20240906","doi-asserted-by":"crossref","first-page":"103126","DOI":"10.1016\/j.critrevonc.2020.103126","article-title":"Osteosarcoma of the jaws:An overview of the pathophysiological mechanisms","volume":"156","author":"Bertin","year":"2020","journal-title":"Crit Rev Oncol Hematol"},{"key":"R2-20240906","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2174\/1874210601004010211","article-title":"Fibroblastic variant of osteosarcoma:A challenge in diagnosis &management","volume":"4","author":"Desai","year":"2010","journal-title":"Open Dent J"},{"key":"R3-20240906","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4103\/ijofb.ijofb_9_18","article-title":"Osteosarcoma of jaws:An insight into literature","volume":"2","author":"Saify","year":"2018","journal-title":"Int J Orofac Biol"},{"key":"R4-20240906","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4103\/0972-1363.44361","article-title":"Osteosarcoma of jaw bone","volume":"20","author":"Dixit","year":"2008","journal-title":"J Indian Acad Oral Med Radiol"},{"key":"R5-20240906","first-page":"1597","article-title":"Osteosarcoma of mandible","volume":"6","author":"Kalburge","year":"2012","journal-title":"J Clin Diagn Res"},{"key":"R6-20240906","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2106\/00004623-200201000-00008","article-title":"Pathologic fracture in osteosarcoma:Prognostic importance and treatment implications","volume":"84","author":"Scully","year":"2002","journal-title":"J Bone Joint Surg Am"},{"key":"R7-20240906","doi-asserted-by":"crossref","first-page":"233","DOI":"10.4103\/0973-029X.99075","article-title":"Osteosarcoma of jaws","volume":"16","author":"Chaudhary","year":"2012","journal-title":"J Oral Maxillofac Pathol"},{"key":"R9-20240906","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1601-0825.2006.01251.x","article-title":"Clinicopathological analysis of osteosarcoma of jaw bones","volume":"13","author":"Nissanka","year":"2007","journal-title":"Oral Dis"},{"key":"R10-20240906","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0901-5027(87)80132-7","article-title":"Osteosarcoma of the jaws \u2013A series from Kaduna, Nigeria","volume":"16","author":"Adekeye","year":"1987","journal-title":"Int J Oral Maxillofac Surg"},{"key":"R11-20240906","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s40744-016-0046-y","article-title":"Review of osteosarcoma and current management","volume":"3","author":"Durfee","year":"2016","journal-title":"Rheumatol Ther"},{"key":"R12-20240906","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/0278-2391(86)90149-7","article-title":"Osteosarcoma of mandible:Analysis of 9 cases","volume":"44","author":"Lindquist","year":"1986","journal-title":"J Oral Maxillofac Surg"},{"key":"R13-20240906","article-title":"Shafer's Textbook of Oral Pathology","author":"Rajendran","year":"2009","journal-title":"Elsevier India"},{"key":"R14-20240906","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1055\/s-0033-1342969","article-title":"Osteosarcoma:Review of the various types with emphasis on recent advancements in imaging","volume":"17","author":"Fox","year":"2013","journal-title":"Semin Musculoskelet Radiol"},{"key":"R15-20240906","doi-asserted-by":"crossref","first-page":"100","DOI":"10.4103\/ijdr.IJDR_792_14","article-title":"Chondroblastic and fibroblastic osteosarcoma of the jaws:Report of two cases and review of literature","volume":"28","author":"Peddana","year":"2017","journal-title":"Indian J Dent Res"},{"key":"R16-20240906","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/his.12138","article-title":"SATB 2 is a novel marker of osteoblastic differentiation in bone and soft tissue tumours","volume":"63","author":"Conner","year":"2013","journal-title":"Histopathology"},{"key":"R17-20240906","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jnci.2018.02.001","article-title":"Osteosarcoma of the jaw:Challenges in the diagnosis and treatment","volume":"30","author":"ElKordy","year":"2018","journal-title":"J Egypt Natl Cancer Inst"}],"container-title":["Journal of Oral and Maxillofacial Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.jomfp_496_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:01:05Z","timestamp":1786647665000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.jomfp_496_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/jomfp.jomfp_496_22","relation":{},"ISSN":["0973-029X","1998-393X"],"issn-type":[{"value":"0973-029X","type":"print"},{"value":"1998-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"2022-11-24","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-06","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}