{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:21:09Z","timestamp":1787775669624,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Rationale:<\/jats:title>\n                    <jats:p>Low-grade intraductal carcinoma (LG-IC), is a rare malignant tumour of the salivary glands which has a very good prognosis and must be differentiated from the other types of salivary gland malignant tumours, which have a totally different behaviour and a worse prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patient Concerns:<\/jats:title>\n                    <jats:p>A case is presented of a 52-year-old woman who was first diagnosed and treated in another clinic in 2019 for an LG-IC in the left submandibular gland space. Two years later, she was admitted to our department with a new lesion, this time in the upper jaw lip on the left side, which also turned out to be LG-IC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Diagnosis:<\/jats:title>\n                    <jats:p>Magnetic resonance imaging and positron emission tomography-computed tomography were performed in order to diagnose and adequately stage the disease prior to the therapeutic intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcomes:<\/jats:title>\n                    <jats:p>A 6-month follow-up reveals no sign of recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Takeaway Lessons:<\/jats:title>\n                    <jats:p>Literature on this rare histopathological entity, as well as the differential diagnosis with the other malignant lesions of the salivary glands and the frequency of metastasis, were reviewed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jomfp.jomfp_500_22","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T04:01:07Z","timestamp":1713153667000},"page":"125-129","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Low-grade intraductal carcinoma in minor salivary glands: A case report and clinical insights"],"prefix":"10.4103","volume":"28","author":[{"given":"Alexandros","family":"Louizakis","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Aristotle University, General Hospital of Thessaloniki G. Papanikolaou, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Tatsis","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Aristotle University, General Hospital of Thessaloniki G. Papanikolaou, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavroula","family":"Papadopoulou","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Aristotle University, General Hospital of Thessaloniki G. Papanikolaou, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Vahtsevanos","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Aristotle University, General Hospital of Thessaloniki G. Papanikolaou, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,4,15]]},"reference":[{"key":"R1-20260302","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jobcr.2018.11.003","article-title":"Low-grade intraductal carcinoma of salivary glands:A systematic review of this rare entity","volume":"9","author":"Giovacchini","year":"2019","journal-title":"J Oral Biol Craniofacial Res"},{"key":"R2-20260302","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.prp.2017.02.019","article-title":"Low-grade intraductal carcinoma (low-grade cribriform cystadenocarcinoma) with tumor-associated lymphoid proliferation of parotid gland","volume":"213","author":"Nishijima","year":"2017","journal-title":"Pathol Res Pract"},{"issue":"Suppl 1","key":"R3-20260302","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s12105-013-0460-1","article-title":"Low-grade salivary duct carcinoma or low-grade intraductal carcinoma?Review of the literature","volume":"7","author":"Kuo","year":"2013","journal-title":"Head Neck Pathol"},{"key":"R5-20260302","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/apm.13009","article-title":"Intraductal carcinomas of the salivary glands:Systematic review and classification of 93 published cases","volume":"128","author":"Palicelli","year":"2020","journal-title":"APMIS"},{"key":"R7-20260302","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1097\/00000478-200608000-00013","article-title":"Low-grade intraductal carcinoma of salivary gland:Report of 3 cases with marked apocrine differentiation","volume":"30","author":"Weinreb","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"R8-20260302","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00795-021-00291-9","article-title":"A rare case of high-grade intraductal carcinoma of the upper lip:immunohistochemical and genetic analyses","volume":"54","author":"Kusafuka","year":"2021","journal-title":"Med Mol Morphol"},{"key":"R9-20260302","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1746-1596-8-80","article-title":"Expression of thyroid transcription factor-1 is associated with a basal-like phenotype in breast carcinomas","volume":"8","author":"Klingen","year":"2013","journal-title":"Diagn Pathol"},{"key":"R10-20260302","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.3892\/mmr.2014.2914","article-title":"Predic Ki67 is a promising molecular target in the diagnosis of cancer (review)","volume":"11","author":"Li","year":"2015","journal-title":"Mol Med Rep"}],"container-title":["Journal of Oral and Maxillofacial Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.jomfp_500_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:38:18Z","timestamp":1787773098000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.jomfp_500_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jomfp.jomfp_500_22","relation":{},"ISSN":["0973-029X","1998-393X"],"issn-type":[{"value":"0973-029X","type":"print"},{"value":"1998-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2022-11-27","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-10","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}