{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:24:59Z","timestamp":1787765099390,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:p>Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide that is etiologically linked to a previous hepatitis B infection. We describe two cases of HCC metastasis to the oral cavity in 60- and 67-year-old male patients. The first case was a diffuse, hard swelling in the left body of the mandible. Histopathologic and immunohistochemical analysis was done, and a positive for CK7, CK19, HEPPAR and TTF and a negative for NAPSIN were found to be diagnostic of metastatic HCC. Subsequent examination of the serum alfa- fetoprotein (AFP) level showed a high value of 450 ng\/ml, confirmatory of HCC. The second case was a pedunculated, reddish, mobile soft tissue growth on the retromolar region. Its macroscopic and histopathologic features themselves were confirmatory of HCC, and the elicited history was corroborant of metastasis.<\/jats:p>","DOI":"10.4103\/jomfp.jomfp_515_22","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T16:08:15Z","timestamp":1725638895000},"page":"579-584","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Metastatic hepatocellular carcinoma of the oral cavity - A report of two cases"],"prefix":"10.4103","volume":"27","author":[{"given":"K","family":"Reesha","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Government Dental College, Kozhikode, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shameena Pazhaningal","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Government Dental College, Kozhikode, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujatha","family":"Varma","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Government Dental College, Kozhikode, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Resmi G.","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Government Dental College, Kozhikode, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,9,12]]},"reference":[{"key":"R1-20240906","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.tripleo.2003.09.018","article-title":"Oral metastasis of a hepatocellular carcinoma","volume":"97","author":"Pires","year":"2004","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol 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