{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:18:28Z","timestamp":1787840308762,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neuroendocrine tumours (NETs) primarily affect the lungs and larynx. Primary neuroendocrine carcinomas (NECs) rarely occur in the oral cavity. The classification of these tumours is ambiguous; however, the literature acknowledges their aggressiveness. Merkel cell carcinoma (MCC) is rare and more common in the skin but could occur intraorally. MCC and NECs are aggressive neoplasms and recommend intensive treatment. In this case report, a 22-year-old female presented with an ulceroinfiltrative lesion in the left buccal mucosa of the cheek, which was diagnosed as primary NEC in the oral cavity. This patient underwent wide local lesion excision of oral cavity mass, ipsilateral selective neck node dissection of levels 1\u20134 and postoperative chemotherapy. This aggressive tumour type requires large local excisions with margins like Merkel cell skin carcinomas. To our knowledge, this is the youngest oral cavity primary neuroendocrine cancer patient to date in the literature.<\/jats:p>","DOI":"10.4103\/jomfp.jomfp_522_23","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T02:00:46Z","timestamp":1728957646000},"page":"474-477","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Large cell neuroendocrine carcinoma of oral cavity: A rare case report with review of literature"],"prefix":"10.4103","volume":"28","author":[{"given":"Anurag","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Pathology, King George Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulshan","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pathology, King George Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma S.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pathology, King George Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mala","family":"Sagar","sequence":"additional","affiliation":[{"name":"Department of Pathology, King George Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,10,15]]},"reference":[{"key":"R1-20241016","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/PAP.0000000000000256","article-title":"An algorithmic immunohistochemical approach to define tumor type and assign site of origin","volume":"27","author":"Bellizzi","year":"2020","journal-title":"Adv Anat Pathol"},{"key":"R2-20241016","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s11154-020-09612-2","article-title":"Classification of neuroendocrine neoplasms: Lights and shadows","volume":"22","author":"La Rosa","year":"2021","journal-title":"Rev Endocr Metab Disord"},{"key":"R3-20241016","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s12022-023-09785-x","article-title":"The spectrum of neuroendocrine neoplasia: A practical approach to diagnosis, classification and therapy by Sylvia L. Asa, Stefano La Rosa, Ozgur Mete","volume":"34","author":"Vanoli","year":"2023","journal-title":"Endocr Pathol"},{"key":"R4-20241016","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s12105-021-01398-2","article-title":"Oral and maxillofacial neuroendocrine carcinoma: A systematic review","volume":"16","author":"Schuch","year":"2022","journal-title":"Head Neck Pathol"},{"key":"R5-20241016","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.ijom.2021.08.021","article-title":"Large cell neuroendocrine carcinoma on the floor of the mouth: A rare entity in an unusual location","volume":"51","author":"Agea Mart\u00ednez","year":"2022","journal-title":"Int J Oral Maxillofac Surg"},{"key":"R6-20241016","doi-asserted-by":"crossref","first-page":"91","DOI":"10.4103\/jomfp.jomfp_460_20","article-title":"Small cell neuroendocrine carcinoma of buccal mucosa: Innocuous but invasive","volume":"26","author":"Narayen","year":"2022","journal-title":"J Oral Maxillofac Pathol"},{"key":"R7-20241016","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s12105-022-01435-8","article-title":"Update from the 5th edition of the world health organization classification of head and neck tumors: Overview of the 2022 WHO classification of head and neck neuroendocrine neoplasms","volume":"16","author":"Mete","year":"2022","journal-title":"Head Neck Pathol"},{"key":"R8-20241016","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.joms.2013.08.020","article-title":"Primary neuroendocrine carcinoma in oral cavity: Two case reports and review of the literature","volume":"72","author":"Wu","year":"2014","journal-title":"J Oral Maxillofac Surg"},{"key":"R9-20241016","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s12105-017-0859-1","article-title":"Merkel cell carcinoma of the buccal mucosa and lower lip","volume":"12","author":"Islam","year":"2018","journal-title":"Head Neck Pathol"},{"key":"R10-20241016","doi-asserted-by":"crossref","first-page":"209217","DOI":"10.1016\/j.tripleo.2010.04.007","article-title":"Oral cavity neuroendocrine carcinoma: A comparison study with cutaneous Merkel cell carcinoma and other mucosal head and neck neuroendocrine carcinomas","volume":"110","author":"Lewis","year":"2010","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R11-20241016","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.neo.2017.09.002","article-title":"Nothing but NET: A review of neuroendocrine tumors and carcinomas","volume":"19","author":"Oronsky","year":"2017","journal-title":"Neoplasia"},{"key":"R12-20241016","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.ijscr.2013.04.028","article-title":"Small cell neuroendocrine tumour of the anterior tongue: A case report","volume":"4","author":"Cymerman","year":"2013","journal-title":"Int J Surg Case Rep"},{"key":"R13-20241016","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.humpath.2019.12.002","article-title":"Immunohistochemistry in the diagnosis and classification of neuroendocrine neoplasms: What can brown do for you?","volume":"96","author":"Bellizzi","year":"2020","journal-title":"Hum Pathol"},{"key":"R14-20241016","doi-asserted-by":"crossref","first-page":"5138","DOI":"10.3390\/jcm12155138","article-title":"A comprehensive review on neuroendocrine neoplasms: Presentation, pathophysiology and management","volume":"12","author":"Sultana","year":"2023","journal-title":"J Clin Med"},{"key":"R15-20241016","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s12105-022-01521-x","article-title":"Top 10 histological mimics of neuroendocrine carcinoma you should not miss in the head and neck","volume":"17","author":"Juhlin","year":"2023","journal-title":"Head Neck Pathol"}],"container-title":["Journal of Oral and Maxillofacial Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.jomfp_522_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:20:00Z","timestamp":1787836800000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.jomfp_522_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jomfp.jomfp_522_23","relation":{},"ISSN":["0973-029X","1998-393X"],"issn-type":[{"value":"0973-029X","type":"print"},{"value":"1998-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2023-12-06","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-08","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}